Schisandrin(Schisandrin) - 在研适应症：急性肾损伤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Sch

靶点-

作用方式-

作用机制-

治疗领域

泌尿生殖系统疾病

在研适应症

急性肾损伤

非在研适应症-

原研机构-

在研机构

西安交通大学

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

关联

1

项与 Schisandrin 相关的临床试验

NCT05223218

/ Enrolling by invitationN/A

Investigating the Diagnostic Potential of Tear Proteins in Breast, Ovarian, Prostate, Melanoma, Pancreatic, and Colon Cancer

This Pilot Study is to investigate the tear proteins in a multitude of cancer types and indulge in biomarker discovery to manufacture simple, accurate, and novel tear-based diagnostic tests.

开始日期2021-08-25

申办/合作机构

Namida Lab, Inc.初创企业

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100 项与 Schisandrin 相关的临床结果

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100 项与 Schisandrin 相关的转化医学

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100 项与 Schisandrin 相关的专利（医药）

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1,037

项与 Schisandrin 相关的文献（医药）

2025-05-01·JOURNAL OF HAZARDOUS MATERIALS

Mechanistic insights into surfactant-induced transformation of chromium-bearing schwertmannite and chromate redistribution during dissolution and recrystallization

Article

作者: Wang, Feng ; Cai, Pingxiong ; Zhang, Yuankai ; Duan, Jiayi ; Chen, Bo

Schwertmannite (Sch) is a typical metastable iron hydroxysulfate mineral found in acid sulfate soil and mine drainage, and it is susceptible to environmental factors and the transformation and concomitant release and re-adsorption of trapped heavy metals. Therefore, understanding the mechanism that induces Sch transformation and governs heavy metal redistributions is integral for both environmental science and geochemistry research. Given the widespread environmental accumulation of surfactants through human activities, an important yet understudied question arises: How do surfactants influence the transformation of Sch under such environmental conditions? To answer this query, this study investigated the transformation of chromium (Cr)-bearing schwertmannite (Sch-Cr) induced by anionic and cationic surfactants and the subsequent redistribution of Cr(VI). Both the surfactant type and pH affected the transformation of minerals. Specifically, at pH 3.0, goethite was the final product, in which the anionic and cationic surfactant promoted and inhibited mineral transformation, respectively. At pH 6.5, hematite was the final transformation product and both anionic and cationic surfactants inhibited the transformation of minerals. For the initial fixed Cr(VI), after 20 d of aging in the presence of sodium dodecylbenzesulfonate (SDBS), Cr(VI) mainly existed in the form of a solution, whereas in the presence of cetrimonium bromide (CTAB), Cr(VI) mainly existed in the newly formed secondary minerals. This study reveals the complex geochemical behavior of Sch under environmental disturbances in acid sulfate soils and provides insights into the use and potential exploitation of Sch as an adsorbent for heavy metal elements.

2025-04-01·Photodiagnosis and Photodynamic Therapy

Evaluation of the effect of subclinical hypothyroidism on retinal blood flow. OCT angiography study

Article

作者: Gunes, Irfan Botan ; Onal, Eda Demir

PURPOSE:

To evaluate retinal blood flow and retinal nerve fiber layer (RNFL) thickness in untreated subclinical hypothyroid patients by optical coherence tomography angiography (OCT-A).

METHODS:

Forty-four eyes of 44 patients in the subclinical hypothyroidism group (SCHG) and 42 eyes of 42 healthy subjects in the control group (CG) were included in the study. Macular superficial retinal blood flow (SRBF), peripapillary RNFL thickness and optic nerve head cup to disk ratio (C/D) were measured and recorded by OCT angiography and compared between the patient and control groups. Correlation analysis between disease duration and SRBF and RNFL thickness was also performed.

RESULTS:

Mean SRBF was 37.23 ± 2.11 in the SCH group and 38.45±1.20 in the control group. Mean SRBF was significantly lower in the SCH group (p=0.003). Mean Peripapillary RNFL thickness was 98.18±7.77 in the SCH group and 100.07 ± 7.71 in control group. Peripapillary RNFL thickness was not significantly different between groups (p=0.290). There was no significant difference in mean C/D between the groups (p=0.708). Correlation analysis showed a moderate negative correlation between duration of disease diagnosis and SRBF in the SCH group (p<0.001, r=-0.564). There was also a weak to moderate negative correlation between disease duration and RNFL thickness in SCH group (p=0.002, r=-0.489).

CONCLUSIONS:

A reduction in SRBF was observed in patients with subclinical hypothyroidism. Additionally, a negative correlation was identified between disease duration and RNFL thickness. Patients with subclinical hypothyroidism should be monitored for potential retinal vascular disease and the development of normotensive glaucoma.

2025-04-01·ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Adsorption of As(III) to schwertmannite: impact factors and phase transformation

Article

作者: Song, Wenjie ; Lü, Changwei ; Wang, Zhongli ; He, Jiang ; Du, Dagula ; Li, Zhichao ; Li, Hao

The phase transformation of Schwertmannite (SCH) can significantly affect the interface behavior and toxic effect of As(III). Previous studies have predominantly focused on pollutants adsorption by SCH on a long-time scale (such as 30 days), without paying attention to the adsorption characteristics within shorter time frames (e.g., within 24 h). This work compared the adsorption characteristics of As(III) on three synthesized SCHs under various environmental conditions. The adsorption of As(III) by M-SCH (SCH synthesized by KMnO₄ oxidation method) and Y-SCH (SCH synthesized by ethanol modification method) were governed by physical adsorption, while that of H-SCH (SCH synthesized by H₂O₂ oxidation method) was dominated by chemisorption. Acidity, selected ions (NO₃^-, Ca²⁺, CO₃^2-, and PO₄^3-), fulvic acid (FA), and Sb(III) adversely impacted the As(III) adsorption by SCHs. Furthermore, alkalinity, selected ions and FA induced the phase transformation of SCHs to iron hydroxide, while no transformation was observed in the presence of Sb(III) and Cr(VI). The iron hydroxide observed in this study is presumed to represent an intermediate stage in the transformation of SCH into goethite. These findings enhance our comprehension of the transformation process of SCH to goethite and provide scientific insights for SCH utilization in immobilizing As(III) in water.

100 项与 Schisandrin 相关的药物交易

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