内异痛经颗粒(Neiyi Tongjing Granules) - 在研适应症：痛经，子宫内膜异位症_专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

神经系统疾病泌尿生殖系统疾病

在研适应症

痛经子宫内膜异位症

非在研适应症-

原研机构

亚宝药业集团股份有限公司

在研机构

亚宝药业集团股份有限公司

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)临床3期

特殊审评-

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关联

1

项与内异痛经颗粒相关的临床试验

CTR20132622 / Recruiting临床3期

评价内异痛经颗粒治疗子宫内膜异位症所致的痛经（气滞血瘀证）安全性、有效性的随机双盲安慰剂平行对照

进一步评价内异痛经颗粒治疗子宫内膜异位症所致痛经（气滞血瘀证）的安全性、有效性

开始日期2012-08-18

申办/合作机构

亚宝药业集团股份有限公司

100 项与内异痛经颗粒相关的临床结果

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100 项与内异痛经颗粒相关的转化医学

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100 项与内异痛经颗粒相关的专利（医药）

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1

项与内异痛经颗粒相关的文献（医药）

Neuropsychiatric Disease and Treatment4区 · 医学

Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model

4区 · 医学

ArticleOA

作者: Huang, Jingbo ; Li, Mingquan ; Zhang, Erli ; Yang, Xueqin ; Zhao, Jianjun ; Dong, Yuxiang

OBJECTIVETo study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain-Barré syndrome classic animal models.MATERIALS AND METHODSIn this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin-eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application.RESULTSWe found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ.CONCLUSIONThis study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain-Barré syndrome.

100 项与内异痛经颗粒相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
痛经	临床3期	中国	亚宝药业集团股份有限公司	2012-08-18
子宫内膜异位症	临床3期	中国	亚宝药业集团股份有限公司	2012-08-18