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更新于：2025-05-07

2 ,4-Dinitrochlorobenzene

2,4-二硝基氯苯

更新于：2025-05-07

概要

基本信息

药物类型

小分子化药

别名

1-chloro-2,4-dinitrobenzene

靶点-

作用方式-

作用机制-

治疗领域

肿瘤感染皮肤和肌肉骨骼疾病

在研适应症

肿瘤疣

非在研适应症-

原研机构-

在研机构-

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C6H3ClN2O4

InChIKeyVYZAHLCBVHPDDF-UHFFFAOYSA-N

CAS号97-00-7

关联

项与 2,4-二硝基氯苯相关的临床试验

NCT06222151

/ RecruitingN/AIIT

Recovering From Bariatric Surgery: the Effects of Early Initiated and Supervised Mobilization

The aim is to investigate the effect of early initiated and supervised mobilization continued after discharge as management of postoperative pain and recovery following obesity surgery, including patient experiences, pain coping, physical functionality and quality of life.

开始日期2024-04-22

申办/合作机构

Novo Nordisk A/S

100 项与 2,4-二硝基氯苯相关的临床结果

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100 项与 2,4-二硝基氯苯相关的转化医学

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100 项与 2,4-二硝基氯苯相关的专利（医药）

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6,019

项与 2,4-二硝基氯苯相关的文献（医药）

2025-06-01·Materials Research Bulletin

Nickel nanoprism containing ppm level of Pd catalysis of reduction and Suzuki-Miyaura reactions

作者: Jose, M. Sansano ; Mohammadi, Soma ; Gholinejad, Mohammad ; Eskandari, Mahboobe

Two types of Nickel nano-prism containing a ppm level of palladium atoms were prepared and their phys. morphol. and prism-like structure were identified.Catalytic investigation of these novel bimetallic nano-prisms showed that Pd on amine-modified (Ni@NH₂-Pd NPr) displayed higher efficiency than one-pot prepared NiPd NPr in reductions of nitroarenes and Suzuki-Miyaura coupling reaction in aqueous media.Using Ni@NH₂-Pd NPr with ppm levels of Pd (8 ppm), a variety of aromatic nitro compounds were reduced to amines in very short reaction times and excellent yields.Also, a synergistic effect between ppm of Pd (8 ppm) and Ni NPr was observed in the Suzuki reaction, and different aryl bromides were successfully used as starters in the Suzuki-Miyaura coupling reaction.The catalyst brings out high TON′s up to 9090 with respect to Pd species, and recyclability and stability of the catalyst were proved.

2025-06-01·Environmental Research

Contaminant bioaccumulation and biochemical responses of the bivalve Scrobicularia plana and the polychaete Hediste diversicolor to ecosystem restoration measures using Zostera noltei

Article

作者: Carvalhais, A ; Pereira, M E ; Mieiro, C L ; Marques, B ; Crespo, D ; Lillebø, A I ; Díez, S ; Oliveira, V H ; Dolbeth, M ; Pacheco, M ; Sousa, A I ; Coelho, J P

A Nature-based Solution (NbS) using Zostera noltei transplants was implemented to restore an area historically contaminated with metals and enhance local environmental conditions. However, the benefits of this restoration approach on the health of resident benthic communities remained unclear, considering the time span of one year of implementation. This study evaluated the short-term effects of transplantation by evaluating bioaccumulation and biochemical responses in Scrobicularia plana and Hediste diversicolor. Overall, the transplanted vegetation played a crucial role in controlling contaminant accumulation, with both species exhibiting lower contaminant levels in vegetated sites compared to bare-bottom sites. The study also revealed species-specific responses to oxidative stress, antioxidant defences and energy budgets, with H. diversicolor being more vulnerable to the absence of vegetation than S. plana. These findings highlight the critical role of vegetation in improving environmental quality and promoting the health of benthic communities, validating the positive effect of the applied restoration measures.

2025-05-01·Talanta

Highly hydrophobic calixarene polymers for efficient enrichment of polar nitrobenzene compounds

Article

作者: Cui, Yongsheng ; Ye, Pengfei ; Peng, Sheng ; Zheng, Juan ; Wang, Zhuo ; Guo, Lihong ; Shen, Zitao ; Liu, Yuefan ; Ouyang, Gangfeng

Macrocyclic polymer materials exhibit excellent selectivity and adsorption performance in pollutant adsorption due to unique host-guest recognition. Herein, three kinds of calixarene polymers (C4P, C6P and C8P) were synthesized through Sonogashira reaction, and were characterized through ¹H NMR, FT-IR, SEM, and TEM. The water contact angle experiments revealed that three kinds of calixarene polymers were highly hydrophobic, and they all exhibited high enrichment efficiency for weak polar chloro-substituted benzene compounds (chlorobenzene, o-chlorotoluene, p-dichlorobenzene and o-dichlorobenzene) and BTEX (benzene, toluene, ethylbenzene and xylenes). Surprisingly, three types of calixarene polymers also showed satisfactory enrichment performance for polar nitrobenzene compounds (NBCs). Among them, C8P showed the most outstanding enrichment factors for NBCs (825-1913), which was about 2-7 times better than those of the commercial fibers. Using C8P as coating fiber, a sensitive analytical method was further developed based on solid phase microextraction (SPME), coupled with gas chromatography-mass spectrometry (GC-MS). The established analytical method demonstrated low detection limits (0.06-5.08 ng L^-1), a wide linear range (0.5-1000 ng L^-1), and good repeatability. The established method was further applied to the quantification of NBCs in environmental water samples, verifying its feasibility.

100 项与 2,4-二硝基氯苯相关的药物交易

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