Nibentan(Nibentan) - 药物靶点：Potassium channel_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

Potassium channel

作用方式

阻滞剂

作用机制

钾离子通道阻滞剂

治疗领域

心血管疾病

在研适应症-

非在研适应症

心律失常

原研机构

Russian Academy of Medical Sciences

在研机构-

非在研机构

Russian Academy of Medical Sciences

权益机构-

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C22H30ClN3O3

InChIKeyCHCBAYRWJULIDW-UHFFFAOYSA-N

CAS号157832-56-9

关联

100 项与 Nibentan 相关的临床结果

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100 项与 Nibentan 相关的转化医学

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100 项与 Nibentan 相关的专利（医药）

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34

项与 Nibentan 相关的文献（医药）

2019-12-01·PHARMACEUTICAL CHEMISTRY JOURNAL

Development of Drug Substances of the Original Class III Antiarrhythmic Drugs Nibentan and Niferidyl

作者: Davydova, N. K.

A review.Publications on the design, synthesis, pharmacol. research, and clin. trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {4-nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride}are reviewed.

2011-12-01·PHARMACEUTICAL CHEMISTRY JOURNAL

Experience in creating new drugs using traditional technologies

作者: Glushkov, R. G. ; Yuzhakov, S. D.

A review. Working hypotheses for the creation of new potential drugs including Class III antiarrhythmic (nibentan, niferidyl), antiallergic (theoritin), and antituberculosis (hixozid) agents are formulated and exptl. data on the activity of the obtained compounds are presented.

2010-11-01·PHARMACEUTICAL CHEMISTRY JOURNAL

Metabolism and pharmacokinetics of nibentan in human blood plasma

作者: G. M. Rodchenkov ; A. B. Bezprozvannyi ; V. A. Gorshkov ; E. M. Zeltyn’ ; A. V. Kukharenko ; M. A. Dikunets ; A. E. Radzevich ; V. G. Valiev ; S. A. Appolonova

An HPLC method with electrospray ionization and ion-trap mass spectral detection (LC-ESI/MSD Ion Trap SL) for determining nibentan metabolites in human blood plasma is described.The proposed method provides simultaneous determination of nibentan and its metabolites in blood plasma.Three metabolites, hydroxylated, de-ethylated, and de-ethylated-hydroxylated, were found in human blood plasma after a single i.v. administration of nibentan (0.125 mg/kg, 1%).De-ethylated nibentan was the longest lived metabolite.The last 2 metabolites were found in human blood plasma for the first time.The results were verified and all metabolites were identified using LC-MS and LC-MS/MS.The major pharmacokinetic parameters were calculated

100 项与 Nibentan 相关的药物交易

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