S. gedanensis ATCC 4880 produced 7 olivanic acids, MM 4550 [12795-21-0], MM 17880 (I) [61036-81-5], MM 22380 (II) [63582-78-5], MM 22381 [63599-16-6], MM 22382 [65376-20-7], MM 22383 [65322-98-7], and MM 13902 [57459-82-2], by fermentation of a medium containing glycerol, soybean flour, and mineral salts.The ratio of sulfated to nonsulfated derivatives was determined by the presence or absence of Na₂SO₄ in the medium.The production of these low-mol.-weight β-lactamase inhibitors was unexpected, because S. gedanensis ATCC 4880 is known to produce KA 107, a high-mol.-weight β-lactamase inhibitor.

1973-09-01·Antimicrobial agents and chemotherapy2区 · 医学

Screening and Isolation of Penicillinase Inhibitor, KA-107

2区 · 医学

Article

作者: Ōmura, S. ; Ohno, H. ; Yamaguchi, N. ; Iwai, Y. ; Hata, T. ; Takeshima, H.

It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolated. The characteristics of this inhibitor were revealed by an in vitro test by using penicillinase derived from penicillin resistant Staphylococcus aureus , FS-1277. When KA-107 was used in combination with penicillin-G, ampicillin, d - or l -phenethicillin, the growth inhibitory activity of these penicillins was maintained.

1973-09-01·Antimicrobial agents and chemotherapy2区 · 医学

In Vitro and In Vivo Activity of Penicillinase Inhibitor KA-107 Against Staphylococcus aureus FS-1277

2区 · 医学

Article

作者: Ōmura, S. ; Iwai, Y. ; Ohno, H. ; Hata, T. ; Matsumae, A. ; Nakae, M.

The activities of penicillinase inhibitor, KA-107 extracted from culture filtrates of Streptomyces gedanensis ATCC 4880, were studied by using penicillin-resistant S. aureus FS-1277 and by means of in vitro and in vivo tests.

100 项与 KA-107 相关的药物交易

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