作者: Yagisawa, Takashi ; Saki, Katano ; Nanmoku, Koji ; Kubo, Taro ; Shinzato, Takahiro ; Nagata, Daisuke ; Kaminaga, Hiroaki ; Kinoshita, Yoshitaka ; Masuda, Takahiro ; Ohara, Ken ; Shimizu, Toshihiro ; Sugase, Taro

A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.

2017-06-01·Journal of the European Academy of Dermatology and Venereology2区 · 医学

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

2区 · 医学

Review

作者: Sánchez‐Borges, M. ; Capriles‐Hulett, A. ; González‐Aveledo, L. ; Maurer, M. ; Caballero‐Fonseca, F.

AbstractBiomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (CSU) are not currently available. A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with CSU was carried out. A search of the medical literature on PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, CSU, severity, prognosis and treatment was performed. Based on our review of the literature, among the clinical markers studied, higher age at onset, being female, long disease duration and aspirin/NSAID hypersensitivity may be linked to both severe CSU and a long time to spontaneous remission. In addition, a positive autologous serum skin test (ASST) may be associated with severe CSU, and comorbidity of inducible urticaria and concomitant recurrent angio‐oedema may be linked to longer CSU duration. Potential biomarkers of CSU severity and/or duration include basophil numbers and susceptibility to activation, inflammatory markers, markers of activation of the extrinsic coagulation pathway, immunoglobulin E and vitamin D. Although the described markers are promising, further studies on representative and well‐characterized patient populations are needed to determine the value of these clinical and biological markers for predicting the severity and course of disease in patients with CSU.

2014-01-30·Asian Pacific Journal of Cancer Prevention

Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer

Article

作者: Nobakht, Hossein ; Dabiri, Reza ; Asadi, Asadollah ; Mahmoudi, Touraj ; Karimi, Khatoon ; Zali, Mohammad Reza ; Farahani, Hamid ; Arkani, Maral ; Vahedi, Mohsen

PURPOSEWith regard to the protective effect of vitamin D against colorectal cancer (CRC), we evaluated genetic variants that might influence vitamin D metabolism: vitamin D receptor (VDR), vitamin D binding protein (GC), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 25-hydroxy 1-alpha hydroxylase (CYP27B1).MATERIALS AND METHODSA total of 657 subjects, including 303 cases with CRC and 354 controls were enrolled in this case-control study. All 657 were genotyped for the four gene variants using PCR-RFLP methods.RESULTSIn this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC. Furthermore, no evidence for effect modification of the variants and CRC by BMI, sex, or tumor site was observed.CONCLUSIONSOur findings do not support a role for VDR, GC, and CYP27B1 genes in CRC risk in our Iranian population. Another interesting finding, which to our knowledge has not been reported previously, was the lack of association with the CYP2R1 gene polymorphism. Nonetheless, our findings require confirmation and possible roles of vitamin D metabolism-related genes in carcinogenesis need to be further investigated.

100 项与 NSAID (SpyGlass Pharma) 相关的药物交易

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