尿激酶(Mochida Pharmaceutical)(Urokinase (Mochida Pharmaceutical)) - 在研适应症：急性心肌梗塞_专利_临床

概要

基本信息

药物类型

酶

别名

URONASE、ウロナーゼ

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病

在研适应症

急性心肌梗塞

非在研适应症-

原研机构

Mochida Pharmaceutical Co., Ltd.

在研机构

Mochida Pharmaceutical Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2007-09-10),

急性心肌梗塞

最高研发阶段(中国)-

特殊审评-

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关联

1

项与尿激酶(Mochida Pharmaceutical) 相关的临床试验

EUCTR2019-001340-22-AT

/ Unknown status临床4期IIT

A prospective, randomized, multicenter trial to compare a Taurolock™based lock solution to a Citrate and Citrate/Urokinase based locksolution in tunneled hemodialysis catheters for the prevention ofbacteremia and dysfunction - CathLock Trial Dialysis

开始日期2020-02-24

申办/合作机构-

100 项与尿激酶(Mochida Pharmaceutical) 相关的临床结果

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100 项与尿激酶(Mochida Pharmaceutical) 相关的转化医学

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100 项与尿激酶(Mochida Pharmaceutical) 相关的专利（医药）

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1

项与尿激酶(Mochida Pharmaceutical) 相关的文献（医药）

1974-01-01·The Tohoku Journal of Experimental Medicine4区 · 医学

Uronase as a Clot Lysis Agent for Acute Thromboembolism in the Lower Extremities

4区 · 医学

Article

作者: MATSUOKA, TOMIO ; OHARA, ITARU

Experimental and clinical studies were carried out to determine the effective dosage of uronase, a preparation of urokinase for blood clot lysis. In vitro study showed that canine and human clots were lysed with about 20-30 units of uronase per ml. Uronase was used in a circulating model, in which an isolated canine liver was perfused for 24 hours. In the perfusion system, a mesh was inserted to remove fibrin during the study. Practically no fibrin was caught on the mesh when uronase was added to the perfusion fluid at the dose as used in the in vitro study. Uronase was administered in 17 cases with acute thromboembolism of the lower extremities with and without surgery. Nine of 11 cases, to which over 30, 000 units were given as an initial dose and then 10, 000 units as a maintenance dose for about a week showed clot lysis, while 3 of 6 cases which received less initial and maintenance dosages of uronase showed less clot lysis.

100 项与尿激酶(Mochida Pharmaceutical) 相关的药物交易

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