Efficacy and Safety of A0001 for Anterior Capsule Staining: Phase III Investigator-initiated Multicenter Clinical Trial - Efficacy and Safety of A0001 for Anterior Capsule Staining

开始日期2017-09-15

申办/合作机构-

NCT01074359 / Terminated临床2期

A Phase 2a, Double Blind, Randomized, Placebo-controlled, 28 Day, Two-arm, Parallel Group Study of A0001 in Patients With the A3243G Mitochondrial DNA Point Mutation and Evidence of Impaired Mitochondrial Function

This is a phase 2a, double-blind, placebo-controlled, single-center study. Twenty-one patients who qualify for the study will be randomly assigned to either active drug or placebo. The study will take place at Newcastle University. Patients will have a 66% chance of getting active drug. Patients will be required to take study treatment orally twice a day for 28 days. A baseline visit will occur within 21 days of screening visit. All patients will be followed for 1 week after completion of study or early withdrawal from the study.

开始日期2010-02-01

申办/合作机构

Penwest Pharmaceuticals Co.

NCT01035671 / Completed临床2期

A Phase 2a, Double-Blind, Randomized, Placebo-Controlled, 28 Day, Three-arm, Parallel Group Study of A0001 in the Treatment of Subjects With Friedreich's Ataxia

This is a Phase 2a double-blind, placebo-controlled study with two dose levels of A0001 given twice daily for 28 days. Potential subjects will be screened first to determine eligibility, after which they will be randomized to receive either a high dose of A0001, a low dose of A0001 or placebo for 28 days.
Eligible subjects will return within 21 days of screening for the baseline visit and randomization to one of three potential treatments. The subjects will be required to take 3 capsules of study medication in the morning with a morning meal and 3 capsules of study medication at night with an evening meal for 28 days. Additional visits to the clinic are planned for Day 14 and Day 28, at which time a number of clinical and biochemical assessments will be done.

开始日期2009-12-01

申办/合作机构

Penwest Pharmaceuticals Co.

100 项与 α-Tocopherolquinone 相关的临床结果

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100 项与 α-Tocopherolquinone 相关的转化医学

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100 项与 α-Tocopherolquinone 相关的专利（医药）

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217

项与 α-Tocopherolquinone 相关的文献（医药）

2024-09-01·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Chemical constituents of Viburnum utile and their inhibitory activities against α-glucosidase].

Article

作者: Long, Chu-Yi ; Yang, Juan ; Li, Qi-Ji ; Hu, Zhan-Xing ; Zhou, Lang

The chemical constituents in the ethanol extract of Viburnum utile were isolated by column chromatography with D101 macroporous resin, silica gel, and Sephadex LH-20. Their structures were identified by spectroscopic techniques such as NMR and MS. All the compounds were evaluated for the inhibitory activities against α-glucosidase. Sixteen compounds were obtained and identified as viburnumide A(1), vitamin E(2), α-amyrin(3), α-tocoquinone(4), narjatamanin B(5), ethyl caffeate(6), naringenin(7), apigenin(8), ethyl β-D-ribo-hex-3-ulopyranoside(9), trans-p-hydroxycinnamic acid(10), amentoflavone(11), apigenin-7-O-β-D-glucoside(12), luteolin-7-O-β-D-glucoside(13), henryoside(14), ursolic acid(15), and 2α-hydroxy-oleanolic acid(16). Among them, compound 1 was a new compound, and compounds 2-16 were isolated from V. utile for the first time. The inhibitory activity(IC_(50) of 4.0 μmol·L~(-1)) of compound 11 against α-glucosidase was comparable to that of the positive control acarbose(IC_(50) of 2.3 μmol·L~(-1)).

2024-07-01·Environmental Health Perspectives

Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study

Article

作者: Pollitt, Krystal J Godri ; Lu, Xiaobo ; Lin, Elizabeth Z ; Guo, Xiaojie ; Sun, Peijie ; Xu, Yibo ; Qian, Jiankun ; Dong, Haoran ; Ding, Enmin ; Zhang, Qian ; Li, Chenfeng ; Shi, Xiaoming ; Guo, Pengfei ; Deng, Fuchang ; Zhao, Wenhua ; Fang, Jianlong ; Tong, Shilu ; Tang, Song ; Ren, Huimin ; Shi, Wanying

BACKGROUNDEvidence suggested that abiotic airborne exposures may be associated with changes in body composition. However, more evidence is needed to identify key pollutants linked to adverse health effects and their underlying biomolecular mechanisms, particularly in sensitive older adults.OBJECTIVESOur research aimed to systematically assess the relationship between abiotic airborne exposures and changes in body composition among healthy older adults, as well as the potential mediating mechanisms through the serum lipidome.METHODSFrom September 2018 to January 2019, we conducted a monthly survey among 76 healthy adults (60-69 years old) in the China Biomarkers of Air Pollutant Exposure (BAPE) study, measuring their personal exposures to 632 abiotic airborne pollutions using MicroPEM and the Fresh Air wristband, 18 body composition indicators from the InBody 770 device, and lipidomics from venous blood samples. We used an exposome-wide association study (ExWAS) and deletion/substitution/addition (DSA) model to unravel complex associations between exposure to contaminant mixtures and body composition, a Bayesian kernel machine regression (BKMR) model to assess the overall effect of key exposures on body composition, and mediation analysis to identify lipid intermediators.RESULTSThe ExWAS and DSA model identified that 2,4,5-T methyl ester (2,4,5-TME), 9,10-Anthracenedione (ATQ), 4b,8-dimethyl-2-isopropylphenanthrene, and 4b,5,6,7,8,8a,9,10-octahydro-(DMIP) were associated with increased body fat mass (BFM), fat mass indicators (FMI), percent body fat (PBF), and visceral fat area (VFA) in healthy older adults [Bonferroni-Hochberg false discovery rate __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__(FDRBH)<0.05]. The BKMR model demonstrated a positive correlation between contaminants (anthracene, ATQ, copaene, di-epi-__-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__α-cedrene, and DMIP) with VFA. Mediation analysis revealed that phosphatidylcholine [PC, PC(16:1e/18:1), PC(16:2e/18:0)] and sphingolipid [SM, SM(d18:2/24:1)] mediated a significant portion, ranging from 12.27% to 26.03% (p-value __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__<0.05), of the observed increase in VFA.DISCUSSIONBased on the evidence from multiple model results, ATQ and DMIP were statistically significantly associated with the increased VFA levels of healthy older adults, potentially regulated through lipid intermediators. These findings may have important implications for identifying potentially harmful environmental chemicals and developing targeted strategies for the control and prevention of chronic diseases in the future, particularly as the global population is rapidly aging. https://doi.org/10.1289/EHP13865.

2024-05-08·Huan jing ke xue= Huanjing kexue

[Characteristics, Sources Apportionment, and Health Risks of PM_2.5-bound PAHs and Their Derivatives Before and After Heating in Zibo City].

Article

作者: Gao, Yu-Zong ; Xu, Bo ; Zhao, Xue-Yan ; Wu, Li-Ping ; Ji, Ya-Qin ; Sun, Gang-Li ; Yang, Wen

Atmospheric polycyclic aromatic hydrocarbons (PAHs) and their derivatives are a global problem that influences the environment and threatens human health. To investigate the characteristics, sources, and health risk assessment of PM_2.5-bound PAHs and their derivatives, PM_2.5 were collected at an urban site in Zibo from November 5 to December 26, 2020, and the concentrations of 16 conventional PAHs, nine NPAHs, and five OPAHs in PM_2.5 were analyzed using gas chromatography-mass spectrometry. Source apportionment of PAHs and their derivatives was conducted using diagnostic ratios and a PMF model, and the health risks of PAHs and their derivatives to adult men and women were evaluated using the source-dependent incremental lifetime cancer risk (ILCR) model. The results showed that the average concentrations of ∑₁₆pPAHs, ∑₉NPAHs, and ∑₅OPAHs in PM_2.5 of Zibo City during the sampling period were (41.61 ± 13.40), (6.38 ± 5.70), and (53.20 ± 53.47) ng·m^-3, respectively. The concentrations of the three PAHs increased significantly after heating, which were 1.31, 2.04, and 5.24 times larger than those before heating. During the sampling period, Chr, BaP, and BaA were the dominant components of pPAHs; 9N-Ant and 2N-Flt + 3N-Flt were the dominant components of NPAHs; and ATQ and BZO were the dominant components of OPAHs. Source apportionment results showed that motor vehicles were the main source of PAHs and their derivatives in PM_2.5 before heating, whereas after heating, the main sources were the mixed source of coal and biomass combustion and secondary formation. The total BaP equivalent (TEQ) was 14.5 ng·m^-3 during the sampling period, and the TEQ increased significantly after heating, which was approximately 1.2 times of that before heating. Assisted by the individual PAH source apportionment results, the ILCR of PM_2.5-boundPAHs and NPAHs in Zibo City had a certain potential carcinogenic risk for adult males (1.06 × 10^-5) and females (9.32 × 10^-6). Among them, the health risks of PAHs from gasoline vehicles, diesel vehicles, and coal/biomass combustion were significantly higher than those from other emission sources.

100 项与 α-Tocopherolquinone 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
神经肌肉疾病	临床2期	英国	Penwest Pharmaceuticals Co.	2010-02-01
呼吸功能不全	临床2期	英国	Penwest Pharmaceuticals Co.	2010-02-01
Friedreich共济失调	临床2期	美国	Endo Pharmaceuticals, Inc.	-
MELAS综合征	临床2期	英国	Endo Pharmaceuticals, Inc.	-
遗传性线粒体呼吸链疾病	临床2期	-	Edison Pharmaceuticals, Inc.	-
遗传性线粒体呼吸链疾病	临床2期	-	Endo International Plc	-