The purpose of this study is to investigate the potential of the local administration of different doses of rosuvastatin (RSV) on autogenous grafted critical-sized cortical bone defects. Twenty-four rats were divided into 3 groups: Group C (control), Group RSV-0.1, and Group RSV-1. A 5-mm diameter critical-size defect was created in the calvarium of each animal. In Group C, the defect was filled by autogenous graft and sterile saline-treated absorbable collagen sponge (ACS) was applied. Defects in the experimental groups (groups RSV-0.1 and RSV-1) were grafted by autogenous graft and ACS with saline solution containing 0.1- and 1-mg RSV were applied. All animals were euthanized at 28 days after operation. Stereologic and micro-computed tomography (μCT) analyses were performed. New bone area and connective tissue volumes were measured. Stereologic analysis showed that the difference between group RSV-1 with a mean bone formation of 1.79 ± 0.06 mm and groups RSV-0.1 and control (C) was statistically significant (P ≤ 0.05) with a mean bone formation of 1.29 ± 0.28 mm and 1.08 ± 0.12 mm, respectively. Connective tissue volume was also significantly higher in 1-mg RSV applicated group. Micro-CT results were similar with stereologic analyses. Local administered 1-mg RSV enhances bone regeneration in critical-size calvarial rat defects filled with autogenous graft.

1965-02-01·Virology3区 · 医学

A heterogeneity of rous sarcoma virus revealed by selectively resistant chick embryo cells

3区 · 医学

Article

作者: Peter K. Vogt

Abstract A preparation of the Bryan high-titer strain of Rous sarcoma virus (RSV) was found to consist of two antigenically distinct variants, designated as RSV-1 and RSV-2. RSV-2 was immunologically related to, but not identical with avian myeloblastosis virus (AMV). RSV-1 showed no such relationship to AMV. RSV-2 differed further from RSV-1 by its growth properties in cell cultures derived from individual chick embryos. About 40% of the embryos from a commercial line of chickens gave tissue cultures resistant to RSV-2, whereas all embryos tested were sensitive to RSV-1. These differences between RSV-1 and RSV-2 proved to be controlled by two helper viruses, RAV-1 and RAV-2. RAV-1 shared with RSV-1 the antigenic makeup and the ability to grow in all chick embryos tested. RAV-2 was antigenically indistinguishable from RSV-2 and was unable to multiply in the same cells which were selectively resistant to RSV-2. The selective cellular resistance to RSV-2 was probably of genetic origin, since no evidence for the presence of an interfering avian leukosis virus could be found. The same resistance was also effective against the Schmidt-Ruppin strain of RSV and certain preparations of AMV.

100 项与 RSV-001 相关的药物交易

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