SLD3(SLD3) - 在研适应症：牙髓疾病_专利_临床

概要

基本信息

药物类型

间充质干细胞疗法

别名-

靶点-

作用机制-

治疗领域

口颌疾病

在研适应症

牙髓疾病

非在研适应症-

原研机构

Chengdu Shilian Kangjian Biotechnology Co., Ltd.

在研机构

Chengdu Shilian Kangjian Biotechnology Co., Ltd.

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

关联

100 项与 SLD3 相关的临床结果

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100 项与 SLD3 相关的转化医学

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100 项与 SLD3 相关的专利（医药）

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1

项与 SLD3 相关的文献（医药）

Plants

Eupatorin and Salviandulin-A, with Antimicrobial and Anti-Inflammatory Effects from Salvia lavanduloides Kunth Leaves

Article

作者: Román-Ramos, Dionisio Celerino ; Jiménez-Ferrer, Enrique ; Zamilpa, Alejandro ; Salinas-Sánchez, David Osvaldo ; Ble-González, Ever A. ; Pérez-García, Ma. Dolores ; Álvarez-Fitz, Patricia ; Herrera-Ruiz, Maribel ; González-Cortazar, Manasés ; Castrejón-Salgado, Ricardo

This study describes the antimicrobial and anti-inflammatory effects from extracts obtained from the leaves of Salvia lavanduloides. The plant material was macerated with three solvents of ascending polarity (n-hexane (Sl-Hex), ethyl acetate (Sl-AcOEt), and dichloromethane (Sl-D)). The extracts, fractions (SlD-2 and SlD-3), and isolated compounds (15,16-epoxy-10-β-hydroxy-neo-cleroda-3,7,13(16),14-tetraene-17,12R:18,19-diolide (1), salviandulin A (2), and eupatorin (3)) were evaluated as antimicrobials against Gram-negative, Gram-positive bacteria and the fungus Candida albicans (Ca) using the minimum inhibitory concentration (MIC) and the anti-inflammatory activity induced by 13-acetate of 12-O-tetradecanoylforbol (TPA). Sl-D and Sl-AcOEt extracts, SlD-2 and SlD-3 fractions showed the highest antimicrobial activity. The isolated compounds showed good activity against Pseudomonas aeruginosa with a MIC < 2 μg/mL, while the anti-inflammatory activity, the Sl-Hex, Sl-D extracts, and SlD-3 fraction presented an inhibition of 62, 45 and 61%, respectively, while (2) 70% and (3) 72%.

100 项与 SLD3 相关的药物交易

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