A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral-Vectored Sudan Ebolavirus Vaccine in Healthy Adults

开始日期2024-07-15

申办/合作机构

Albert B. Sabin Vaccine Institute, Inc.

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100 项与 Ebola Sudan vaccine(Albert B. Sabin Vaccine Institute) 相关的临床结果

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100 项与 Ebola Sudan vaccine(Albert B. Sabin Vaccine Institute) 相关的转化医学

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100 项与 Ebola Sudan vaccine(Albert B. Sabin Vaccine Institute) 相关的专利（医药）

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117

项与 Ebola Sudan vaccine(Albert B. Sabin Vaccine Institute) 相关的文献（医药）

2024-10-01·Journal of Separation Science

Preparation of a New Hexafluorobutanol‐Farnesol Based Supramolecular Solvent and Its Application in Microextraction of Sudan Dyes From Beverage and Water Samples

Article

作者: Li, Qi ; Huang, Xianjin ; Liu, Hanqing ; Ge, Dandan ; Wang, Yigeng ; Huang, Yao ; Weng, Zhehui ; Wang, Yingzhen

ABSTRACTIn this work, a new supramolecular solvent (SUPRAS) was prepared for the first time using hexafluorobutanol (HFB) and farnesol (FO). FO acts as an amphiphile and HFB as a coacervation inducer and density regulator. The method of dispersive liquid‐liquid microextraction followed by high‐performance liquid chromatography, supported by a vortex technique, was established using the prepared SUPRAS for the determination of Sudan dyes in aqueous samples. The extraction parameters, including FO content, HFB content, vortex time, salt addition, and solution pH, were thoroughly investigated and optimized. Under the optimized conditions, the linearity range is 10–750 ng/mL for Sudan I, and 10–1000 ng/mL for Sudan III and Sudan IV, respectively. The limits of detection for Sudan dyes were in the range of 0.8–3.1 ng/mL. The inter‐ and intra‐day relative standard deviations for Sudan dyes were in the range of 1.3%–4.1% and 0.2%–2.6%, respectively. Finally, the proposed method was applied to the determination of Sudan dyes in beverage and river water samples with recoveries ranging from 93.9% to 122.1%. Compared to conventional techniques for the extraction of Sudan dyes in real samples, the proposed method is simpler, faster, and more environmentally friendly.

2024-06-01·Food Chemistry

A sharp and selective fluorescence paper-based sensor based on inner filter effect for ratiometric detection of four Sudan dyes in food matrix

Article

作者: Zhang, Yueli ; Zhang, Jinyuan ; Cai, Da ; Gao, Fuhua ; Shi, Tian

The addition of Sudan dyes with carcinogenic effects to food threatens human health. Herein, a ratiometric fluorescence strip consisting of core-shell upconversion particles (NaYF₄:Yb,Tm@NaYF₄:Yb,Er), metal-organic frameworks and dual-template molecularly imprinted polymers was developed to selectively and sensitively detect four Sudan dyes based on inner filter effect (detection time only takes 8 min). The high adsorption capacity of metal-organic frameworks and the greater overlap between the emission of NaYF₄:Yb,Tm@NaYF₄:Yb,Er and the absorbance of four Sudan dyes enable the signal responses to be more sensitive. The limits of detection in chilli powder samples are as low as 29.87 ng/g, 37.55 ng/g, 47.89 ng/g and 51.02 ng/g, with satisfactory recovery (93.32-103.4%) and minor relative standard deviations (≤4.3%). This method broadens the idea for low-cost and portable detection of multiple illegal additives in complex substrates with high selectivity and sensitivity based on one kind of fluorescent strip.

2024-04-01·Clinical Case Reports

Sudan black poisoning resulted in methemoglobinemia in a baby with congenital chyloperitoneum

作者: Eelmäe, Imbi ; Lintrop, Mare ; Nerman, Jekaterina ; Padari, Helgi ; Kipper, Karin ; Metsvaht, Tuuli

Key Clinical MessageTreatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization of the site of lymphatic leakage is crucial, but radiological imaging is technically complicated and may not provide sufficient information, especially in small patients. To ease the detection of lymphatic leakage during surgery, preoperative feeding with fat‐rich formula with Sudan Black has been recommended. However, administration of Sudan Black may result in life‐threatening methemoglobinemia and liver damage without any advantage of revealing leakage during surgery. We recommend preoperative feeding with pure fat‐rich formula.

100 项与 Ebola Sudan vaccine(Albert B. Sabin Vaccine Institute) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
苏丹埃博拉病毒感染	临床2期	肯尼亚	Albert B. Sabin Vaccine Institute, Inc.	2024-07-15
苏丹埃博拉病毒感染	临床2期	乌干达	Albert B. Sabin Vaccine Institute, Inc.	2024-07-15
埃博拉病毒性疾病	临床1期	美国	Albert B. Sabin Vaccine Institute, Inc.	-