M-1217(M-1217) - 药物靶点：FXR_专利_临床

概要

基本信息

药物类型

化学药

别名-

靶点

FXR

作用机制

FXR激动剂(胆汁酸受体FXR激动剂)

治疗领域

免疫系统疾病消化系统疾病

在研适应症-

非在研适应症

炎症性肠病

原研机构

Metacrine, Inc.

在研机构-

非在研机构

Metacrine, Inc.

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 M-1217 相关的临床结果

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100 项与 M-1217 相关的转化医学

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100 项与 M-1217 相关的专利（医药）

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1

项与 M-1217 相关的文献（医药）

2000-12-01·Infection and Immunity2区 · 医学

Formation of Methyl Mercaptan from l -Methionine by Porphyromonas gingivalis

2区 · 医学

Article

作者: Saito, Toshiyuki ; Yamashita, Yoshihisa ; Nakano, Yoshio ; Koga, Toshihiko ; Yoshimura, Mamiko ; Oho, Takahiko

ABSTRACT Methyl mercaptan production by oral bacteria is thought to be one of the main causes of oral malodor. We examined the ability of periodontopathic Porphyromonas gingivalis to produce methyl mercaptan from l -methionine and found that the invasive strains W83 and W50 produced large amounts of methyl mercaptan. We cloned and sequenced the mgl gene encoding l -methionine-α-deamino-γ-mercaptomethane-lyase (METase) from P. gingivalis W83. The structural mgl gene consisted of 1,200 bp and encoded a 43.3-kDa protein. To examine the role of methyl mercaptan in the pathogenesis of P. gingivalis , a METase-deficient mutant of P. gingivalis W83 was constructed. The methionine degradation activity and virulence of the mutant (M1217) and the parent strain (W83) in mice were compared. M1217 showed a marked decrease in the formation of methyl mercaptan from l -methionine and decreased virulence compared with the wild-type strain W83. These results suggest that methyl mercaptan not only is one of the sources of oral malodor, but may also play a role in the pathogenicity of P. gingivalis.

100 项与 M-1217 相关的药物交易

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