â??Single-Center, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Combination of Diclofenac Sodium 1% with Triclocarban in Subjects with Painful Diabetic Peripheral Neuropathyâ??

开始日期2012-08-01

申办/合作机构-

100 项与双氯芬酸钠/三氯卡班相关的临床结果

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100 项与双氯芬酸钠/三氯卡班相关的转化医学

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100 项与双氯芬酸钠/三氯卡班相关的专利（医药）

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578

项与双氯芬酸钠/三氯卡班相关的文献（医药）

2026-12-31·BLOOD PRESSURE

Association between urine triclocarban concentration and the prevalence of hypertension based on a cross-sectional study

Article

作者: Yang, Ming ; Zhou, Shenglan ; Du, Lin ; Xia, Guangwei

BACKGROUND:

There is a correlation between triclocarban exposure and adverse health effects, but the association between triclocarban and hypertension remains unknown. This study is to investigate the relationship between urinary triclocarban and the risk of hypertension in adults.

METHODS:

Participants were enrolled from the National Health and Nutrition Examination Surveys. The urinary concentrations of triclocarban were measured by derivatization gas chromatography-mass spectrometry. Odds ratio (OR) and 95% confidence interval (CI) of urinary triclocarban associating with hypertension were estimated with by multivariable logistic regressions. Non-linear correlations were explored using restricted cubic splines. Subgroup analysis was carried out to examine the interactive effects.

RESULTS:

The highest tertiles of triclocarban comparing the lowest tertiles was associated with higher risk of hypertension in unadjusted model (OR 1.93, 95%CI 1.53 to 2.44; p < 0.001), partly-adjusted model (OR 1.48, 95%CI 1.11 to 1.97; p = 0.008), and fully-adjusted model (OR 1.31, 95%CI 1.02 to 1.80; p = 0.043). Subgroup analysis showed that the relationship was consistent across gender, age, race, and BMI groups.

CONCLUSIONS:

Urinary triclocarban was associated with the prevalence of hypertension, after adjusting for traditional risk factors.

2026-07-01·COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Metabolomic changes associated with behavioral and molecular findings: Triclocarban toxicity in the zebrafish model

Article

作者: Sulukan, Ekrem

BACKGROUND AND AIM:

Triclocarban (TCC), an antimicrobial agent used in personal care products, has been widely detected in aquatic ecosystems and has raised significant concerns for aquatic organisms and human health. This study aimed to investigate the neurotoxic effects of TCC exposure, a broad-spectrum bactericide, through behavioral, molecular, pathological, and metabolomic analyses.

METHODS:

For this purpose, adult zebrafish were exposed to TCC at doses of 3, 10, and 30 μg/L for 96 h, and their brain tissues were removed. Subsequently, behavioral (anxiety and circadian rhythm tests), molecular (qPCR), histopathological, and metabolomic analyses were performed on these fish.

RESULTS:

The data obtained showed that TCC treatment increased anxiety-like behaviors in zebrafish and caused disruptions in the circadian rhythm. Additionally, it was determined that the expression levels of both core clock genes (Bmal and Gnat2) and genes associated with neuroplasticity, stress response, and neurotransmission (Bdnf, Crhr, 5-ht4, Ache) changed significantly in a dose-dependent manner compared to the control group. Additionally, it was observed that TCC increased degeneration and necrosis in the brain in parallel with the dose increase, while raising 8-OHdG and BDNF protein levels and decreasing NRF2 and SIRT1 protein levels. When metabolomic analysis data were evaluated, it was determined that TCC, especially at the highest dose, significantly altered metabolite levels.

CONCLUSION:

These results reveal that TCC, beyond being an environmental pollutant, may cause behavioral disorders and neurotoxic effects.

2026-06-01·JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Halogenated phenolic disinfectants suppress 11β-hydroxysteroid dehydrogenase 2 activity in human and rat models: Experimental and computational evidence

Article

作者: Tang, Yunbing ; Fei, Qianjin ; Pan, Chengshuang ; Ge, Ren-Shan ; Lu, Binbin ; Zhang, Qian ; Ou, Rongying ; Chi, Chuhang

Halogenated phenolic disinfectants (HDs) are widely used in industrial and personal care products. However, whether these HDs inhibit human and rat 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity to interfere with glucocorticoid metabolism remains unclear. Michaelis-Menten kinetics showed high 11β-HSD2 activity (human placenta: Km, 46.0 nM, Vmax, 48.21pmol/mg/min; rat kidney: Km, 50.01 nM, Vmax, 70.6pmol/mg/min). Screening at 100 µM revealed significant inhibition by most HDs (residual activity <50%), except triclocarban and trichloroacetone. Dose-response assays identified hexachlorophene as the most potent inhibitor (human IC₅₀, 3.83 µM; rat IC₅₀, 1.48 µM). The binding affinities of hexachlorophene and dichlorophene were assessed using Surface Plasmon Resonance, showing KDs of 10.60 and 48.50 μM, respectively. Enzyme kinetics and Lineweaver-Burk plots demonstrated mixed inhibition by HDs, suggesting dual interference with substrate binding and NAD⁺ binding. In human BeWo trophoblast cells, HDs differentially suppressed cortisone formation, with dichlorophene, bromochlorophene, and fenticlor showing inhibition even at 1 µM. Molecular docking revealed HDs binding to NAD⁺ and cortisol binding sites in human 11β-HSD2, with hexachlorophene forming hydrogen bonds with catalytic residues (Ser219, Tyr232). Structure-activity relationship (SAR) and 3D-QSAR analyses highlighted inverse correlations between inhibitory potency and LogP/molecular volume (r = 0.9214 for pharmacophore). ADMET (absorption, distribution, metabolism, elimination, and toxicity) profiling indicated poor solubility, high plasma protein binding, and potential hepatotoxicity. Network toxicology analysis for hypertensive disorders of pregnancy (including gestational hypertension and preeclampsia), now supported by cellular bioassay data, implicates this dysregulated pathway in the potential pathogenesis of HD-induced disorders. These findings elucidate HDs as potent, species-conserved 11β-HSD2 inhibitors with mixed mechanisms, underscoring their endocrine-disrupting potential and structure-dependent bioactivity.

项与双氯芬酸钠/三氯卡班相关的新闻（医药）

2025-07-23

·EINPresswire

Topical Antiseptic Products: Hand Sanitizers and Antibacterial Soaps

FDA is undertaking a review of active ingredients used in a variety of over-the-counter (OTC) antiseptic rubs and wash products. Health care antiseptics are being evaluated separately from consumer antiseptics because they have different proposed use settings and target populations, and the risks for infection in the different settings varies. More information about both is presented below. What are antiseptics? Over-the-counter consumer antiseptics can generally be broken down into two groups: washes and rubs. The definition for each is below. Washes Antiseptic wash products, also known as antibacterial soaps, are intended for use with water and are rinsed off after use, and include hand washes /soaps and body washes. FDA supports the CDC’s recommendation to use plain soap and water to wash your hands. When water is not readily available, a hand sanitizer may be a suitable alternative. Rubs Rubs are leave-on products, or hand “sanitizers,” as well as antiseptic wipes. These products are intended to be used when soap and water are not available, and are left on and not rinsed off with water. Remember: Just like with all over-the-counter drugs, it is important to read the label every time you use hand sanitizers or antiseptic wipes. These products should be stored out of the reach of children and should be used with adult supervision. Use hand sanitizers and antiseptic wipes only as directed on the label. Do not swallow them. If you swallow these products call a poison control center immediately. What is the difference between health care antiseptics and consumer antiseptics? Health Care Antiseptics Health care antiseptics differ from consumer antiseptics in the following ways: They are primarily used by health care professionals in hospitals, clinics, doctors’ offices, outpatient settings and nursing homes. Health care antiseptics are not only used to protect the user but also to protect the patient, whereas consumer antiseptics are generally applied to protect the user. Health care antiseptics are often used more frequently by health care workers than consumers use consumer antiseptics. Consumer Antiseptics Consumer antiseptics differ from healthcare antiseptics in the following ways: Consumer antiseptics are primarily used in the home, schools, daycares or other public settings. Most consumer antiseptics are sold in retail establishments like drug stores and grocery stores. How are health care and consumer antiseptics being evaluated? FDA compares the risks and the benefits for active ingredients under specified conditions of their use to help determine whether that active ingredient is generally recognized as safe and effective (GRASE). Since FDA’s 1994 evaluation of OTC antiseptics, many things have changed, including the frequency of use of some products, new technology that can detect low levels of antiseptics in the body, FDA’s safety standards, and scientific knowledge about the impact of widespread use. FDA’s current effort is designed to ensure that the safety and effectiveness evaluations and determinations for active ingredients used in antiseptics are consistent, up-to-date, and appropriately reflect current scientific knowledge and increasing use patterns. Safety FDA proposed that data was needed from a standard battery of tests that is used to determine the safety of many drugs, including OTC antiseptics. This array of tests has changed over time to incorporate improvements in safety testing. For more specific information on safety tests, please see the final rule on consumer antiseptic washes , the final rule on health care antiseptics , and the final rule on consumer antiseptic rubs . Efficacy For consumer antiseptic washes , millions of Americans use antiseptic hand soaps and body washes each day, but these products have not yet been shown to be more effective at preventing illness than plain soap and water. Additionally, emerging data have raised concerns that long-term, daily use of these products may outweigh their presumed benefits. The clinical studies data on effectiveness would specifically need to demonstrate that the active ingredients in consumer antiseptic wash products are superior to non-antibacterial soap in preventing illness or reducing infection. FDA has issued a final rule requiring the removal of certain active ingredients from OTC consumer antibacterial hand soaps and body washes including the most commonly used triclosan and triclocarban. Antibacterial manufacturers did not provide the necessary data to demonstrate the effectiveness for these active ingredients and so the FDA could not determine that they are generally recognized as safe and effective for use in consumer antiseptic washes. For more specific information on effectiveness testings for active ingredients used in consumer antiseptic washes, please see the final rule on consumer antiseptic washes . FDA is not proposing clinical outcome studies for active ingredients when used in health care antiseptics or in consumer antiseptic rub products. FDA is requiring clinical simulation studies for health care antiseptics because of ethical concerns with conducting studies in the health care setting; FDA is requiring the clinical simulation studies for consumer antiseptic rubs because these products are intended for use when soap and water are not available, and so they need not demonstrate clinical effectiveness compared to soap and water. For specific information on the efficacy data requested for health care antiseptics and consumer antiseptic rubs, please see the final rules on health care antiseptics and final rule on consumer antiseptic rubs and their respective dockets. Regulatory Information More information Health care antiseptics Content current as of: 06/18/2020 Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.