â??Single-Center, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Combination of Diclofenac Sodium 1% with Triclocarban in Subjects with Painful Diabetic Peripheral Neuropathyâ??

开始日期2012-08-01

申办/合作机构-

100 项与双氯芬酸钠/三氯卡班相关的临床结果

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100 项与双氯芬酸钠/三氯卡班相关的转化医学

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100 项与双氯芬酸钠/三氯卡班相关的专利（医药）

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580

项与双氯芬酸钠/三氯卡班相关的文献（医药）

2026-01-01·ENVIRONMENTAL RESEARCH

Exposure to triclosan and triclocarban is associated with estrogen metabolism in Chinese pregnant women

Article

作者: Lin, Guankai ; Wen, Xiaoting ; Zhao, Ke ; Hong, Sumiao ; Xu, Xiaoyang ; Wang, Yi ; Liu, Jiaqi ; Wang, Na ; Wang, Jiwei ; Huang, Min ; Sun, Baochang ; Jiang, Qingwu ; Chen, Yue ; Chen, Yuanyuan ; Wang, Hexing ; Zhou, You ; Wang, Yuanping ; Lin, Haiping

BACKGROUND:

Exposure to triclosan and triclocarban has been proposed to disrupt estrogen metabolism, but relevant human studies remain limited, especially among pregnant women.

METHODS:

A cross-sectional study was conducted in 432 pregnant women aged 18-42 years selected from the Wenzhou Mother and Child Cohort Study. Urinary concentrations of triclosan, triclocarban, and three estrogens (estrone (E₁), 17β-estradiol (E₂), and estriol (E₃)) were measured by liquid chromatography coupled to mass spectrometry. The associations of urinary triclosan and triclocarban with urinary estrogens were analyzed using linear regression models and restricted cubic spline analysis.

RESULTS:

Triclosan and triclocarban were detected in 60.2 % and 25.9 % of urine samples, respectively. After trichotomizing urinary triclocarban concentrations based on limit of detection and median of urinary creatinine-corrected concentration among positive samples, pregnant women in tertile 3 showed a higher urinary E₁ concentration in the adjusted model (regression coefficient (β) = 0.26, 95 % confidence interval (CI): 0.01, 0.52, p = 0.045). After stratified by pregnancy trimester, for pregnant women in the first trimester of pregnancy, those in tertile 2 of urinary triclosan had a marginally higher urinary E₁ concentration (β = 0.25, 95 %CI: 0.03, 0.47, p = 0.029) and those in tertile 3 showed lower urinary concentrations of E₁ (β = -0.28, 95 %CI: 0.50, -0.05, p = 0.017) and E₂ (β = - 0.19, 95 %CI: 0.36, -0.01, p = 0.034). For pregnant women in the second/third trimester of pregnancy, those in tertile 3 of urinary triclosan had a marginally higher urinary E₁ concentration (β = 0.26, 95 %CI: 0.04, 0.55, p = 0.090). An approximately inverted U shape was observed for the association of urinary triclosan with E₁ and E₂ in the first trimester of pregnancy.

CONCLUSIONS:

Exposure to triclosan and triclocarban may disrupt estrogen metabolism during pregnancy with a difference by pregnancy trimester and some non-monotonic dose responses.

2025-12-01·JOURNAL OF HAZARDOUS MATERIALS

Optimal matrix identification of parabens, triclosan and triclocarban for biomonitoring: Comparative analysis in urine, whole blood, serum, and plasma

Article

作者: Lu, Shaoyou ; Li, Xinjie ; Shan, Chiqun ; Bian, Junye ; Chen, Tao ; Wu, Xiaoru ; Lin, Kai ; Fu, Bo ; Chen, Xulong ; Chen, Yiran ; Chen, Weizhong ; Lin, Yuli ; Sun, Guangyu

Despite the risk of endocrine disruption, the choice of the optimal biological matrix for monitoring parabens, triclosan (TCS), and triclocarban (TCC) remains unresolved. This study addresses this gap by comprehensively comparing paired urine, whole blood, serum, and plasma samples from 70 Chinese participants. By integrating exposure assessment with methodological evaluation, we analyze matrix effects (ME), extraction recovery, precision, and contaminant distribution using liquid chromatography-tandem mass spectrometry. A multidimensional framework was developed, incorporating weighted correlations, discriminative ability, descriptive statistics, and methodological robustness, to identify the most suitable matrices. Key findings revealed that: (1) urine exhibited minimal matrix interference with polar parabens, with a 100 % detection rate (DR) for short-chain parabens and excellent discrimination ability; (2) serum achieved optimal recovery for moderately polar analytes through fibrinogen removal (TCS recovery: 116.3 %; median concentration: 2.94 μg/L); (3) plasma enabled reliable quantification of lipophilic compounds despite ionization enhancement (butylparaben DR: 100 % in plasma vs. 85.7 % in urine); and (4) whole blood showed significant signal suppression (TCC ME 40.8 %), requiring specialized pretreatment. Based on multidimensional assessment, the optimal matrices were determined as follows: urine for methylparaben and ethylparaben, whole blood for propylparaben, serum for benzylparaben and butylparaben, and plasma for TCS and TCC. Consequently, a standardized protocol was established: urine for routine parabens biomonitoring, plasma/serum for trace antimicrobial testing, and phospholipid removal for whole blood applications.

2025-12-01·SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Enhanced binding of triclocarban to catalase induced by coexisting nanoplastics

Article

作者: Lan, Jing ; Shi, Rongguang ; Zhao, Zongshan ; Li, Yaru ; Wang, Yaoyao ; Lou, Qi ; Guan, Rui ; Zong, Wansong

Triclocarban (TCC), as an emerging environmental contaminant, can induce changes of catalase (CAT) activities and the oxidative stress. Nanoplastics have also been found to readily bind to functional proteins and affect their physiological expressions. However, their combined toxicities are still not clearly illustrated at molecule level. Here, we explored the impact of polystyrene nanoplastics (PSNPs) on the binding of TCC to CAT, using a combination of spectroscopy, enzyme activity assays, dynamic light scattering analysis and molecular docking. The results show that CAT activity was overactivated and increased to 131 % and 138 % (TCC = 6 μM) by TCC alone and NPs-TCC exposure, respectively. Dynamic light scattering analysis demonstrate that CAT was adsorbed on the surface of PSNPs and formed a protein corona. Fluorescence, UV-visible and circular dichroism spectra analyses reveal that loosening of the CAT backbone and the reduction in α-helix content induced by TCC was further exacerbated by PSNPs. This structural perturbation may enhance the binding affinity of TCC to CAT. The coexistence of PSNPs and TCC could further increase CAT activity compared to individual TCC, probably being attributed to protein corona formation and enhanced conformational changes of CAT induced by PSNPs. These findings will contribute to the understanding of the oxidative damage in the co-existence of TCC and PSNPs, and provide new insights into the toxic effects in coexisting scenarios.

项与双氯芬酸钠/三氯卡班相关的新闻（医药）

2025-07-23

·EINPresswire

Topical Antiseptic Products: Hand Sanitizers and Antibacterial Soaps

FDA is undertaking a review of active ingredients used in a variety of over-the-counter (OTC) antiseptic rubs and wash products. Health care antiseptics are being evaluated separately from consumer antiseptics because they have different proposed use settings and target populations, and the risks for infection in the different settings varies. More information about both is presented below. What are antiseptics? Over-the-counter consumer antiseptics can generally be broken down into two groups: washes and rubs. The definition for each is below. Washes Antiseptic wash products, also known as antibacterial soaps, are intended for use with water and are rinsed off after use, and include hand washes /soaps and body washes. FDA supports the CDC’s recommendation to use plain soap and water to wash your hands. When water is not readily available, a hand sanitizer may be a suitable alternative. Rubs Rubs are leave-on products, or hand “sanitizers,” as well as antiseptic wipes. These products are intended to be used when soap and water are not available, and are left on and not rinsed off with water. Remember: Just like with all over-the-counter drugs, it is important to read the label every time you use hand sanitizers or antiseptic wipes. These products should be stored out of the reach of children and should be used with adult supervision. Use hand sanitizers and antiseptic wipes only as directed on the label. Do not swallow them. If you swallow these products call a poison control center immediately. What is the difference between health care antiseptics and consumer antiseptics? Health Care Antiseptics Health care antiseptics differ from consumer antiseptics in the following ways: They are primarily used by health care professionals in hospitals, clinics, doctors’ offices, outpatient settings and nursing homes. Health care antiseptics are not only used to protect the user but also to protect the patient, whereas consumer antiseptics are generally applied to protect the user. Health care antiseptics are often used more frequently by health care workers than consumers use consumer antiseptics. Consumer Antiseptics Consumer antiseptics differ from healthcare antiseptics in the following ways: Consumer antiseptics are primarily used in the home, schools, daycares or other public settings. Most consumer antiseptics are sold in retail establishments like drug stores and grocery stores. How are health care and consumer antiseptics being evaluated? FDA compares the risks and the benefits for active ingredients under specified conditions of their use to help determine whether that active ingredient is generally recognized as safe and effective (GRASE). Since FDA’s 1994 evaluation of OTC antiseptics, many things have changed, including the frequency of use of some products, new technology that can detect low levels of antiseptics in the body, FDA’s safety standards, and scientific knowledge about the impact of widespread use. FDA’s current effort is designed to ensure that the safety and effectiveness evaluations and determinations for active ingredients used in antiseptics are consistent, up-to-date, and appropriately reflect current scientific knowledge and increasing use patterns. Safety FDA proposed that data was needed from a standard battery of tests that is used to determine the safety of many drugs, including OTC antiseptics. This array of tests has changed over time to incorporate improvements in safety testing. For more specific information on safety tests, please see the final rule on consumer antiseptic washes , the final rule on health care antiseptics , and the final rule on consumer antiseptic rubs . Efficacy For consumer antiseptic washes , millions of Americans use antiseptic hand soaps and body washes each day, but these products have not yet been shown to be more effective at preventing illness than plain soap and water. Additionally, emerging data have raised concerns that long-term, daily use of these products may outweigh their presumed benefits. The clinical studies data on effectiveness would specifically need to demonstrate that the active ingredients in consumer antiseptic wash products are superior to non-antibacterial soap in preventing illness or reducing infection. FDA has issued a final rule requiring the removal of certain active ingredients from OTC consumer antibacterial hand soaps and body washes including the most commonly used triclosan and triclocarban. Antibacterial manufacturers did not provide the necessary data to demonstrate the effectiveness for these active ingredients and so the FDA could not determine that they are generally recognized as safe and effective for use in consumer antiseptic washes. For more specific information on effectiveness testings for active ingredients used in consumer antiseptic washes, please see the final rule on consumer antiseptic washes . FDA is not proposing clinical outcome studies for active ingredients when used in health care antiseptics or in consumer antiseptic rub products. FDA is requiring clinical simulation studies for health care antiseptics because of ethical concerns with conducting studies in the health care setting; FDA is requiring the clinical simulation studies for consumer antiseptic rubs because these products are intended for use when soap and water are not available, and so they need not demonstrate clinical effectiveness compared to soap and water. For specific information on the efficacy data requested for health care antiseptics and consumer antiseptic rubs, please see the final rules on health care antiseptics and final rule on consumer antiseptic rubs and their respective dockets. Regulatory Information More information Health care antiseptics Content current as of: 06/18/2020 Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.