F-10863B(F-10863B) - _专利_临床

概要

基本信息

药物类型

未知

别名

靶点-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症-

非在研适应症

高脂血症

原研机构

Sankyo & Co. Ltd.

在研机构-

非在研机构

Sankyo & Co. Ltd.

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 F-10863B 相关的临床结果

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100 项与 F-10863B 相关的转化医学

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100 项与 F-10863B 相关的专利（医药）

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1

项与 F-10863B 相关的文献（医药）

1998-01-01·The Journal of Antibiotics4区 · 医学

Inhibitory Activity to Protein Prenylation and Antifungal Activity of Zaragozic Acid D3, a Potent Inhibitor of Squalene Synthase Produced by the Fungus, Mollisia sp. SANK 10294.

4区 · 医学

Article

作者: Satoshi Ohya ; Tatsuo Tanimoto ; Yoshio Tsujita

Recently we found novel zaragozic acids (ZAs), F-10863A (zaragozic acid D3, ZAD3), B, C and D in the culture broth of the fungus Mollisia sp. SANK 10294 as potent inhibitors of squalene synthase. There are several other enzymes that use farnesylpyrophosphate as their substrate. Among them we chose farnesyl-protein transferase and examined whether ZAD3 and F-10863B inhibit this enzyme's activity. ZAD3 and F-10863B inhibited farnesyl-protein transferase with IC50 values of 0.60 and 3.7 microM, respectively. They also inhibited geranylgeranyl-protein transferase at similar concentrations. In addition, they exhibited potent antifungal activity.

100 项与 F-10863B 相关的药物交易

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