the study is about using healthy bacteria to improve the overall gingival and overall health and prevent or decrease the bad odor of the mouth caused by bad bacteria

开始日期2025-04-03

申办/合作机构

University of Al-Mustansiriyah

100 项与 Probiotics(University of Al-Mustansiriyah) 相关的临床结果

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100 项与 Probiotics(University of Al-Mustansiriyah) 相关的转化医学

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100 项与 Probiotics(University of Al-Mustansiriyah) 相关的专利（医药）

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8,313

项与 Probiotics(University of Al-Mustansiriyah) 相关的文献（医药）

2025-12-31·Gut Microbes

Microbial diversity and fitness in the gut–brain axis: influences on developmental risk for Alzheimer’s disease

Review

作者: Hulme, John P. ; An, Seong Soo A. ; Jamerlan, Angelo M.

The gut-brain axis (GBA) denotes the dynamic and bidirectional communication system that connects the gastrointestinal tract and the central nervous system (CNS). This review explored this axis, focusing on the role of microbial diversity and fitness in maintaining gastrointestinal health and preventing neurodegeneration, particularly in Alzheimer's disease (AD). Gut dysbiosis, characterized by the imbalance in populations of beneficial and harmful bacteria, has been associated with increased systemic inflammation, neuroinflammation, and the progression of AD through pathogenic mechanisms involving amyloid deposition, tauopathy, and increased blood-brain barrier (BBB) permeability. Emerging evidence highlighted the therapeutic potential of probiotics, dietary interventions, and intermittent fasting in restoring microbial balance, reducing inflammation, and minimizing neurodegenerative risks. Probiotics and synbiotics are promising in helping improve cognitive function and metabolic health, while dietary patterns like the Mediterranean diet were linked to decreased neuroinflammation and enhanced gut-brain communication. Despite significant advancement, further research is needed to elucidate the specific microbial strains, metabolites, and mechanisms influencing brain health. Future studies employing longitudinal designs and advanced omics technologies are essential to developing targeted microbiome-based therapies for managing AD-related disorders.

2025-12-31·Gut Microbes

Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives

Review

作者: Qu, Yi ; Zhang, Deshuang ; Mu, Dezhi ; Wang, Shaopu ; Xie, Dongke

Necrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate the complex pathogenesis of NEC, integrating insights from clinical, microbial, and molecular perspectives. It emphasizes the modulation of NEC-associated inflammatory pathways by probiotics and novel biologics, highlighting their therapeutic potential. We further critically examine dysbiotic alterations within the gut microbiota, with a particular focus on imbalances in bacterial and viral communities, which may contribute to the onset of NEC. The intricate interactions among toll-like receptor 4 (TLR4), microvascular integrity, immune activation, and the inflammatory milieu are meticulously summarized, offering a sophisticated understanding of NEC pathophysiology. This academic review aims to enhance the etiological comprehension of NEC, promote the development of targeted therapeutic interventions, and impart the significant impact of perinatal factors on the formulation of preventive and curative strategies for the disease.

2025-12-31·Gut Microbes

Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity

Review

作者: Meisel, Marlies ; Lee, Amanda H. ; Rodriguez Jimenez, Daphne Michelle

The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity of Bulgarian villagers to their consumption of sour milk fermented by Lactobacilli. His pioneering work led to the global recognition of probiotics as beneficial supplements, now a multibillion-dollar industry. Modern probiotics have been extensively studied for their immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), a widely used probiotic, has garnered significant attention for its systemic immune-regulatory properties, particularly in relation to autoimmunity and cancer. This review delves into the role of L. reuteri in modulating immune responses, with a focus on its impact on systemic diseases.

100 项与 Probiotics(University of Al-Mustansiriyah) 相关的药物交易

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