A Phase 3 Superiority Study Comparing the Safety and Efficacy of SNP-ACTH (1-39) Gel Compared to Rituximab and FDA Approved Biosimilars in Adults With Primary Membranous Nephropathy (PMN) in a Two-Phase Adaptive Trial Design

The goal of the Phase 3a part of this clinical trial is to determine the optimal dose that will be used in the Phase 3b part of this clinical trial. The goal of the Phase 3b part is to assess the efficacy of SNP-ACTH (1-39) Gel relative to rituximab in patients with primary membranous nephropathy (PMN) at month 24.

开始日期2023-03-13

申办/合作机构

Cerium Pharmaceuticals, Inc.

100 项与 SNP-ACTH (1-39) 相关的临床结果

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100 项与 SNP-ACTH (1-39) 相关的转化医学

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100 项与 SNP-ACTH (1-39) 相关的专利（医药）

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项与 SNP-ACTH (1-39) 相关的文献（医药）

1986-02-01·General and Comparative Endocrinology3区 · 医学

In vitro study of frog (Rana ridibunda pallas) interrenal function by use of a simplified perifusion system VIII. Structure-activity relationship of synthetic ACTH fragments and γ-MSH

3区 · 医学

Article

作者: Perroteau, I. ; Lihrmann, I. ; Delarue, C. ; Ling, N. ; Netchitailo, P. ; Leboulenger, F. ; Vaudry, H.

The present study was undertaken to determine the structure-activity relationships of ACTH analogs on corticosteroid production by frog adrenal gland. Rana ridibunda interrenal dice were perifused with amphibian culture medium for 10 hr. Corticosterone and aldosterone concentrations were measured in the effluent perifusate using sensitive and specific radioimmunoassay methods. Perifusion of interrenal fragments with increasing concentrations of synthetic human ACTH 1-39 (ranging from 6.25 X 10(-11) to 10(-9) M) led to a linear log-dose increase in both corticosterone and aldosterone secretion. Thus, this model made it possible to compare the steroidogenic potency of several ACTH analogs. Synthetic alpha-MSH and its des-N alpha-acetyl derivative were found to be approximately equipotent, and 5 X 10(3) times less active than authentic ACTH. The short-chain analog ACTH 1-10 was 2 X 10(4) times less potent than ACTH whereas ACTH 4-10 was totally inactive. A fragment of the N-terminal region of the proopiomelanocortin molecule, gamma 3-MSH, caused a dose-related stimulation of steroid secretion. However, in contrast to what has been observed in the rat, gamma 3-MSH did not potentiate the corticotropic action of ACTH on frog interrenal gland. Since processing of proopiomelanocortin in frog intermediate lobe generates high amounts of alpha-MSH and des-N alpha-acetyl alpha-MSH, these results suggest that in amphibians, several peptides other than ACTH may be involved in the control of corticosteroidogenesis.

1983-09-01·Peptides3区 · 医学

Intracranial administration of corticotropin-like peptides increases incidence of amphibian reproductive behavior

3区 · 医学

Article

作者: Frank L. Moore ; Larry J. Miller

Male rough-skinned newts (Taricha granulosa) exhibit an increase in sexual behavior (amplectic clasping) following intracerebroventricular (ICV) injection of adrenocorticotropin (ACTH 1-39), ACTH 4-10, or melanocyte-stimulating hormone (alpha MSH). In contrast, intraperitoneal (IP) administration of ACTH 1-39 or corticosterone significantly decreases the incidence of sexual behavior in male newts. These results suggest that a corticotropin-like peptide acts centrally to enhance sexual behavior and that systemic ACTH acts on the interrenal tissue to inhibit sexual behavior by stimulating the release of corticosterone.

1981-06-01·Regulatory Peptides

Stimulation of the adenylate cyclase of a B16 melanoma cell line by pro-opiocortin-related peptides — A structure-activity study

Article

作者: Stephen Tomlinson ; S.S. Bleehen ; Sheila Mac Neil ; Barry L. Brown ; Stuart K. Johnson

The ability of alpha-melanotrophin (alpha-MSH or ACTH 1-acetyl-13 amide) and other structurally related peptides derived from the common precursor, pro-opiocortin, to stimulate adenylate cyclase activity in a pigmented B16 mouse melanoma was investigated. The peptides ACTH 1-39, ACTH 1-24, alpha-MSH, ACTH 1-13 amide and beta-MSH all stimulated the enzyme to a similar maximal extent and with similar potency (ED50 = 1.3 . 10(-6) M) except that ACTH 1-39 was slightly less potent (ED50 = 5 . 10(-6) M). ACTH 4-10 (ED50 = 4 . 10(-5) M) and gamma-MSH (ED50 = 5 . 10(-6) M) were partial agonists. ACTH 1-10 was no more effective than ACTH 4-10 in stimulating the enzyme whereas ACTH 1-13 amide was a full agonist. The peptides beta-endorphin and its derivatives, Met-enkephalin and melanotrophin potentiating factor (MPF), failed to stimulate the enzyme. We suggest that the B16 melanoma requires not only the sequence ACTH 4-10 but also some part of the sequence ACTH 11-13, or a similar sequence in the terminal portion of beta-MSH, for full activation of the receptor-linked enzyme.

100 项与 SNP-ACTH (1-39) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
特发性膜性肾病	临床3期	美国	Cerium Pharmaceuticals, Inc.	2023-03-13
特发性膜性肾病	临床3期	印度	Cerium Pharmaceuticals, Inc.	2023-03-13
特发性膜性肾病	临床3期	加拿大	Cerium Pharmaceuticals, Inc.	2023-03-13