The primary objective of this study is to compare the efficacy of hydrogen peroxide versus normal saline in postoperative care of sutured wounds. Subjects will be randomly assigned to standard of care hydrogen peroxide or standard of care normal saline in postoperative care of sutured wounds followed by applying petroleum jelly and sterile gauze bandage. Data will be collected at day 0 and between days 7 to14. Subjects will provide irritation scale rating (0-4) with 0 being none/absent and 4 being severe/extreme.

开始日期2015-10-01

申办/合作机构

Northwestern University

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100 项与 SUL-121 相关的转化医学

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100 项与 SUL-121 相关的专利（医药）

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5,540

项与 SUL-121 相关的文献（医药）

2025-01-01·Journal of Ethnopharmacology

Bioactivity of Talisia esculenta extracts: Antioxidant and anti-inflammatory action on RAW 264.7 macrophages and protective potential on the zebrafish exposed to oxidative stress inducers

Article

作者: Cordeiro, Maria Lúcia da Silva ; Silva, Maylla Maria Correia Leite ; Paiva, Weslley de Souza ; Scortecci, Katia Castanho ; Silva, Ariana Pereira da ; Luchiari, Ana Carolina ; Queiroz Aquino Martins, Verônica Giuliani de ; Queiroz Aquino-Martins, Verônica Giuliani de ; Rocha, Hugo Alexandre Oliveira

ETHNOPHARMACOLOGICAL RELEVANCETalisia esculenta is a fruit tree commonly found in various regions of Brazil. Its fruit is consumed by the local population, and the leaves are used in infusions within traditional Brazilian medicine. These infusions are employed to alleviate pathological conditions such as rheumatic diseases and hypertension, both of which are strongly linked to oxidative stress and chronic inflammation. The investigation of plant extracts represents a promising field of research, as bioactive compounds abundant in plants exhibit pharmacological effects against a variety of pathological conditions.AIM OF THE STUDYTo investigate the antioxidant, anti-inflammatory activities, and toxicity of the infusion and hydroethanolic extracts of T. esculenta leaves (IF and HF) and fruit peels (IC and HC).MATERIALS AND METHODSInitially, the cytotoxicity and the effects of the extracts on oxidative stress in RAW264.7 macrophages were assessed through exposure to H₂O₂, as well as their impact on NO production in RAW264.7 macrophages exposed to LPS. Additionally, the toxicity and ROS production in zebrafish larvae were evaluated using two oxidative stress inducers: H₂O₂ and CuSO₄ combined with ascorbate.RESULTSThe MTT assay indicated that the extracts exhibited low cytotoxicity, with HF and IF demonstrating protective effects against H₂O₂ exposure. HC reduced NO production in macrophages by 30%. The zebrafish analysis showed that all four T. esculenta extracts (100 μg/mL) were non-toxic, as they did not affect the survival, heart rate, or body size of the animals. Furthermore, all extracts were capable of reducing ROS levels in zebrafish larvae exposed to the H₂O₂ stressor. Notably, ROS reduction by HF, IF, and HC extracts exceeded 50% compared to the positive control (H₂O₂ alone). T. esculenta extracts also demonstrated a significant ability to reduce ROS levels in zebrafish larvae exposed to CuSO₄, with a 70% reduction observed for leaf extracts and over 30% for fruit peel extracts.CONCLUSIONThis study demonstrated that T. esculenta extracts exhibit significant activity against oxidative damage and contain components with anti-inflammatory properties. Among the extracts, those obtained from leaves were the most effective in providing oxidative protection, supporting the traditional use of leaf infusions.

2024-12-01·Journal of Hazardous Materials

Controllable fabrication of high-quantum-yield bimetallic gold/silver nanoclusters as multivariate sensing probe for Hg2+, H2O2, and glutathione based on AIE and peroxidase mimicking activity

Article

作者: Chen, Siqi ; Chai, Fang ; Mao, Baodong ; Song, Ying ; Tian, Miaomiao ; Tang, Wei ; Yan, Rui

The grave threat posed by heavy metals and food hazards has increased the urgency of rapid and precise detection for food security and human health. Efficient multivariate sensing probes are imperatively required for sensing heavy metals and tumor markers, which are still facing great challenge in terms of multi-functional integration. Here, bimetallic gold-silver nanoclusters (NG-AuAgNCs) were developed with unique aggregation-induced-emission (AIE) property and peroxidase (POD) mimicking activity towards the efficient multivariate sensing via optimization of the precursors. The NG-AuAgNCs emitted at 614 nm and enable AIE feature with lifetime of 12.61 μs and high quantum yield of 40.5%. Possessing AIE and POD activity, the NG-AuAgNCs show great potential as fluorimetric and colorimetric dual-mode probe for multivariate sensing Hg²⁺, H₂O₂ and GSH, with good recoveries in real samples. The NG-AuAgNCs paper sensors further integrating with smartphone, achieved portable detection of Hg²⁺ with limit of detection (LOD) of 19 nM, while the colorimetric-mode presented consecutive response to H₂O₂ and GSH via a reversible oxidase tetramethylbenzidine process with LODs of 7.02 and 0.45 μM, respectively. This work not only demonstrates a multivariate probe for environment and human health, but also provides valuable insights for the function integration of the nanocluster via synthetic manipulation.

2024-12-01·Environmental Pollution

Challenges in Raman spectroscopy of (micro)Plastics: The interfering role of colourants

Article

作者: Vanoirbeek, Jeroen A.J. ; Ronsmans, Steven ; Ghosh, Manosij ; Vanoirbeek, Jeroen A J ; Hoet, Peter H.M. ; Azari, Aala ; Hoet, Peter H M

Rising plastic consumption leads to widespread microplastic (MP) contamination. Raman spectroscopy is widely used for MP identification due to its ability to analyse particles as small as 1 μm. However, it faces challenges such as interference from pigments and additives. In this study, we aim to assess the accuracy of Raman micro-spectroscopy in identifying coloured plastic samples by applying various oxidative treatments to eliminate the possible interference effect caused by colourants associated with the sample. Standard and coloured microplastics were analysed using a Raman imaging microscope. Coloured plastics were treated with H₂O₂ 30%, Sodium hypochlorite 5%, and Fenton reagent ( H2O2 30% and Ferrous sulphate 0.2 M) for 24, 48, and 72 hours. The Raman spectra were acquired after treatment to assess the impact of the treatment procedure on the polymer identification. Our results revealed that colourants significantly impact Raman spectra by peak broadening and/or fluorescence effects, which reduces identification accuracy and match scores Red pigments particularly obscure polymer identification. Treatments like oxidation and Fenton's reagent showed limited effectiveness. Additives in plastic samples can affect the accuracy of polymer identification by the Raman spectroscopy technique. Common treatment procedures do not improve the accuracy of identification. In order to improve the reliability of Raman analysis, essential factors such as utilizing multiple excitation lasers and appropriate CCD detectors, establishing a comprehensive reference library of colourants and additives, and employing advanced techniques like time-gated Raman spectroscopy or Surface-Enhanced Raman Spectroscopy (SERS) should be considered.

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
糖尿病肾病	临床前	荷兰	University of Groningen	-
糖尿病肾病	临床前	荷兰	Sulfateq BV	-
慢性阻塞性肺疾病	临床前	荷兰	Universitair Medisch Centrum Groningen	-
慢性阻塞性肺疾病	临床前	加拿大	University of Manitoba	-
慢性阻塞性肺疾病	临床前	荷兰	Sulfateq BV	-