Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population

The purpose of this study is to assess the efficacy and safety of the combination of mebendazole plus quinfamide for the treatment of intestinal helminthiasis and amoebiasis in Mexican population.

开始日期2005-10-01

申办/合作机构

Janssen-Cilag Ltd.

100 项与喹法米特相关的临床结果

登录后查看更多信息

100 项与喹法米特相关的转化医学

登录后查看更多信息

100 项与喹法米特相关的专利（医药）

登录后查看更多信息

项与喹法米特相关的文献（医药）

2020-07-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Comparative study of eco-friendly spectrophotometric methods for accurate quantification of Mebendazole and Quinfamide combination; Content uniformity evaluation

Article

作者: Naguib, Ibrahim A ; Abdelaleem, Eglal A ; Emam, Aml A ; Hassan, Eman S

Development and validation of accurate and selective spectrophotometric methods were carried out for determination of a new combination of Mebendazole and Quinfamide in bulk powder and pharmaceutical formulation. Extended ratio subtraction coupled with isoabsorptive point methods were used for determination of the binary mixture. A comparative study was carried out between the newly developed methods; simultaneous ratio subtraction, absorbance subtraction, and dual wavelength spectrophotometric methods were applied as well. The developed methods were validated in accordance with the ICH guidelines. The developed methods were successfully carried out for determination of Quinfamide and Mebendazole in Vermox Plus® tablets. Upon statistical comparison of the results obtained by the developed methods with those obtained by the reported simultaneous equation spectrophotometric method, no significant difference was shown among them. Moreover, the introduced methods have the advantages of being more sensitive and have wider linearity ranges than other reported spectrophotometric methods.

2020-01-01·Journal of Chromatographic Science4区 · 化学

Development and Validation of HPTLC and Green HPLC Methods for Determination of a New Combination of Quinfamide and Mebendazole

4区 · 化学

Article

作者: Emam, Aml A ; Hassan, Eman S ; Abdelaleem, Eglal A ; Naguib, Ibrahim A

AbstractTwo selective and sensitive chromatographic methods were developed for simultaneous determination of new combination of quinfamide and mebendazole in bulk powder and in pharmaceutical formulation. The first method is HPTLC by which separation was obtained using silica gel HPTLC F254 plates and a simple mobile phase consisting of methanol:toluene (2:6, v/v) and the separated bands were scanned at 254 nm. The second method RP-HPLC that comprised isocratic separation of both drugs on a Phenomenex C18 column using a green mobile phase consisting of double distilled water:methanol (30:70, v/v) at a flow rate of 0.8 mL/min and UV detection at 254 nm. The developed methods were validated and proved to meet ICH guidelines. Successful application of the developed methods was carried out for determination of quinfamide and mebendazole in Vermox Plus® tablets. Statistical comparison between the developed chromatographic methods and the reported simultaneous equation spectrophotometric method showed that there was no significant difference between them, proving the ability of applying the proposed methods in quality control testing of the studied drugs. The developed methods are considered the first chromatographic methods for simultaneous determination of quinfamide and mebendazole; moreover, they offered sensitive and selective eco-friendly methods for analysis of the studied drugs.

2002-03-01·The American journal of tropical medicine and hygiene4区 · 医学

Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children.

4区 · 医学

Article

作者: Trujillo-Hernandez, Benjamin ; Vasquez, Clemente ; Davila-Gutierrez, Cesar E. ; Huerta, Miguel

The present study was carried out to evaluate the effectiveness of nitazoxanide compared with that of quinfamide, mebendazole, or both in the treatment of intestinal protozoa and helminthic infections. A total of 677 stool specimens from children aged 2-12 years living in 3 communities of Colima, MÃ©xico, were analyzed in order to detect the presence of cysts, trophozoites, eggs, or larvae of intestinal protozoa or helminths. A total of 275 infected children were enlisted in a double-blind controlled study and randomly assigned to one of 2 treatment groups: Group A, nitazoxanide (200 mg for 3 days) and Group B, quinfamide (100 mg for 1 day), mebendazole (200 mg for 3 days), or both. A posttreatment fecal examination was conducted on Day 14 from treatment initiation. In Group A (n = 143), the parasitosis eradication rate was superior to that of Group B (n = 132). However, there was no significant difference between the 2 groups (P > 0.05).

100 项与喹法米特相关的药物交易

登录后查看更多信息