更新于：2024-11-21

Gadomelitol

更新于：2024-11-21

概要

研发状态

概要

基本信息

药物类型

造影剂、化学药

别名

Vistarem

靶点-

作用机制

磁共振成像增强剂

治疗领域

肿瘤神经系统疾病心血管疾病+ [2]

在研适应症-

非在研适应症

心血管疾病脑血管疾病造影剂+ [2]

原研机构

Guerbet SA

在研机构-

非在研机构

Guerbet SAGuerbet France SAS

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C232H320Br12N32O116.Gd.H

InChIKeySPEOBOARQOCRFA-GTPOWFTASA-K

CAS号308814-41-7

关联

100 项与 Gadomelitol 相关的临床结果

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100 项与 Gadomelitol 相关的转化医学

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100 项与 Gadomelitol 相关的专利（医药）

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项与 Gadomelitol 相关的文献（医药）

2020-02-01·Pesticide Biochemistry and Physiology2区 · 生物学

Biotransformation and detoxification of chloroacetanilide herbicides by Trichoderma spp. with plant growth-promoting activities

2区 · 生物学

Article

作者: Bernat, Przemysław ; Słaba, Mirosława ; Nykiel-Szymańska, Justyna

Due to the increasing use of chlorinated organic compounds, environmental pollution is a key issue in agricultural and industrial areas. In this study, biodegradation of chloroacetanilide herbicides, such as alachlor and metolachlor, by eight fungal strains of Trichoderma spp. originating from different microorganism collections was investigated. The tested fungi converted 80-99% of alachlor and 40-79% of metolachlor after 7 days of incubation. Biotransformation of herbicides was performed mainly by dechlorination and hydroxylation reactions. Eight alachlor metabolites and four byproducts of metolachlor conversion were detected in Trichoderma cultures, including two metolachlor intermediates for the first time identified in fungi. Moreover, in the cultures of six Trichoderma strains supplemented with chloroacetanilides, a decrease in toxicity was observed toward tested Artemia franciscana crustaceans. Simultaneously, 7 days after the application of the spores of T. koningii IM 0956, T. citrinoviride IM 6325, T. harzianum KKP 534, T. viride KKP 792 and T. virens DSM 1963 the length of roots and shoots of rapeseed seedlings treated with alachlor or metolachlor significantly increased. All tested strains exhibited plant growth-promoting traits, such as siderophore production, 1-aminocyclopropane-1-carboxylate deaminase (ACCD) activity, and phosphate solubilization, even in the presence of chloroacetanilide herbicides.

2015-01-01·Korean Journal of Radiology3区 · 医学

Dynamic Contrast-Enhanced MRI Using a Macromolecular MR Contrast Agent (P792): Evaluation of Antivascular Drug Effect in a Rabbit VX2 Liver Tumor Model

3区 · 医学

Article

作者: Han, Joon Koo ; Choi, Jin-Young ; Yoon, Jung Hwan ; Park, Hee Sun ; Woo, Sungmin ; Kim, Young Il ; Choi, Byung Ihn ; Lee, Jeong Min

OBJECTIVETo evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models.MATERIALS AND METHODSThis study was approved by our Institutional Animal Care and Use Committee. DCE-MRI was performed with 3-T scanner in 13 VX2 liver tumor-bearing rabbits, before, 4 hours after, and 24 hours after administration of vascular disrupting agent (VDA), using gadomelitol (P792, n = 7) or low molecular weight contrast agent (gadoterate meglumine [Gd-DOTA], n = 6). P792 was injected at a of dose 0.05 mmol/kg, while that of Gd-DOTA was 0.2 mmol/kg. DCE-MRI parameters including volume transfer coefficient (K(trans)) and initial area under the gadolinium concentration-time curve until 60 seconds (iAUC) of tumors were compared between the 2 groups at each time point. DCE-MRI parameters were correlated with tumor histopathology. Reproducibility in measurement of DCE-MRI parameters and image quality of source MR were compared between groups.RESULTSP792 group showed a more prominent decrease in K(trans) and iAUC at 4 hours and 24 hours, as compared to the Gd-DOTA group. Changes in DCE-MRI parameters showed a weak correlation with histologic parameters (necrotic fraction and microvessel density) in both groups. Reproducibility of DCE-MRI parameters and overall image quality was not significantly better in the P792 group, as compared to the Gd-DOTA group.CONCLUSIONDynamic contrast-enhanced magnetic resonance imaging using a macromolecular contrast agent shows changes of hepatic perfusion more clearly after administration of the VDA. Gadolinium was required at smaller doses than a low molecular contrast agent.

2013-04-01·Acta Oncologica2区 · 医学

Assessment of the interstitial fluid pressure of tumors by dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights

2区 · 医学

Article

作者: Rofstad, Einar K. ; Ellingsen, Christine ; Hompland, Tord ; Gulliksrud, Kristine

BACKGROUNDCancer patients showing highly elevated interstitial fluid pressure (IFP) in the primary tumor may benefit from particularly aggressive treatment. There is some evidence that gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be a useful non-invasive method for providing information on the IFP of tumors. The purpose of this preclinical study was to investigate whether any association between DCE-MRI-derived parametric images and tumor IFP can be strengthened by using MR contrast agents with higher molecular weights than that of Gd-DTPA.MATERIAL AND METHODSA-07 human melanoma xenografts were used as preclinical models of human cancer. Three contrast agents were compared: Gd-DTPA (0.55 kDa), P846 (3.5 kDa), and gadomelitol (6.5 kDa). A total of 46 tumors were subjected to DCE-MRI and subsequent measurement of IFP. Parametric images of K(trans) (the volume transfer constant of the contrast agent) and v(e) (the fractional distribution volume of the contrast agent) were produced by pharmacokinetic analysis of the DCE-MRI series.RESULTSSignificant inverse correlations were found between median K(trans) and IFP for Gd-DTPA (p = 0.0076; R(2) = 0.46; n = 14) and P846 (p = 0.0042; R(2) = 0.45; n = 16), whereas there was no correlation between median K(trans) and IFP for gadomelitol (p > 0.05; n = 16). Significant correlation between median v(e) and IFP was not found for any of the contrast agents (p > 0.05 for Gd-DTPA, P846, and gadomelitol).CONCLUSIONK(trans) images, but not v(e) images, derived by pharmacokinetic analysis of DCE-MRI data for low-molecular-weight contrast agents may provide information on the IFP of tumors. Any association between K(trans) and IFP cannot be expected to be improved by using contrast agents with higher molecular weights than those of Gd-DTPA and P846.

100 项与 Gadomelitol 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Gadomelitol	-	-

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
心血管疾病	临床3期	美国	Guerbet SA	2003-03-19
心血管疾病	临床3期	法国	Guerbet SA	2003-03-19
肿瘤	临床3期	法国	Guerbet SA	2000-12-31
肿瘤	临床3期	美国	Guerbet SA	2000-12-31
脑血管疾病	临床3期	-	Guerbet France SAS	-
造影剂	临床3期	-	Guerbet France SAS	-
肝病	临床3期	-	Guerbet France SAS	-