亚硝酸钠/硫代硫酸钠(Sodium Nitrite/Sodium Thiosulfate) - 在研适应症：中毒_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Nithiodote、Sodium Thiosulfate Hydrate/Sodium nitrite

靶点-

作用机制

一氧化氮供体、硫原子供体

治疗领域

其他疾病

在研适应症

中毒

非在研适应症-

原研机构

Hope Pharmaceuticals, Inc.

在研机构

Hope Pharmaceuticals, Inc.

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2011-01-14),

中毒

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

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结构

分子式H12Na2O8S2

InChIKeyJIWXHKJJHDWKGC-UHFFFAOYSA-N

CAS号10102-17-7

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关联

9

项与亚硝酸钠/硫代硫酸钠相关的临床试验

TCTR20230517002 / Recruiting临床1/2期IIT

Inhaled nitrite therapy for pulmonary hypertension in connective tissue diseases

开始日期2023-09-01

申办/合作机构

Mahidol University

NCT02742129 / Completed临床2期IIT

Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF

A randomized, double-blind, placebo-controlled crossover study to assess the effect of inorganic nitrite (NO2) on aerobic capacity (peak VO2) after four weeks of dosing. Approximately 100 participants will be enrolled in this 2*2 crossover study.

开始日期2016-08-10

申办/合作机构

Duke University

[+6]

NCT02694393 / Terminated临床1/2期IIT

Phase I/II Study of Inhaled Sodium Nitrite as an Antimicrobial for Pseudomonas Infection in Cystic Fibrosis

This study will assess the safety of inhaled sodium nitrite in adults with Cystic Fibrosis and chronic Pseudomonas infections, and determine the ability of sodium nitrite to reduce the burden of Pseudomonas.

开始日期2016-02-01

申办/合作机构

Cystic Fibrosis Foundation

[+1]

100 项与亚硝酸钠/硫代硫酸钠相关的临床结果

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100 项与亚硝酸钠/硫代硫酸钠相关的转化医学

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100 项与亚硝酸钠/硫代硫酸钠相关的专利（医药）

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35

项与亚硝酸钠/硫代硫酸钠相关的文献（医药）

2024-07-01·Current Opinion in Nephrology & Hypertension

New therapeutic perspectives for vascular and valvular calcifications in chronic kidney disease

Review

作者: Sinha, Smeeta ; Huish, Sharon

Purpose of reviewVascular and valvular calcification are associated with cardiovascular morbidity and mortality in people with chronic kidney disease (CKD). Uncertainty exists regarding therapeutic strategies to attenuate calcification. This review outlines the pathophysiological mechanisms contributing to vascular and valvular calcification, considers the mechanisms of action of therapeutic interventions, and reports the latest outcomes from interventional studies.Recent findingsConventional therapies targeted at CKD-mineral and bone disorder (MBD) modulation have yielded conflicting or inconclusive results. Magnesium and vitamin K supplementation appear to offer attenuation of coronary artery calcification but inconsistent findings justify the need for further studies. Strategies targeting hydroxyapatite formation such as sodium thiosulphate and hexasodium fytate show promise and are worthy of further evaluation. The serum calcification propensity assay (T50) correlates with severity and progression; it holds promise as a potential future clinical tool for screening monitoring calcification risk.SummaryWhilst knowledge of the pathophysiology of vascular calcification has grown and therapeutic approaches appear promising, as yet no medication has been approved to treat vascular or valvular calcification, or calciphylaxis.

2023-12-19·ACS Omega

Insights into the Characterization of the Self-Assembly of Different Types of Amphiphilic Molecules Using Dynamic Light Scattering

Article

作者: Bouhadda, Youcef ; Fergoug, Teffaha ; El Hariri El Nokab, Mustapha ; Aribi, Rachida ; Sebakhy, Khaled O ; Van Steenberge, Paul H M ; Yssaad, Fatima ; Kadiri, Aicha ; Daikh, Zineeddine

The self-assembly of cetyltrimethylammonium bromide, sodium dodecylsulfate, Triton X-100, and sulfobetaine surfactants in aqueous solutions was examined by dynamic light scattering, both in the presence and absence of 0.1 M NaCl salt, across various temperatures. For each surfactant, critical parameters, such as concentration and phase transition temperatures, of micelles were determined by monitoring changes in the hydrodynamic diameter with concentration and temperature. Additionally, we explored the self-assembly behavior of these surfactants when they are introduced alongside polystyrene nanoparticles. Our findings enabled the elucidation of surfactant molecule adsorption mechanisms onto polystyrene nanoparticle surfaces. Furthermore, by analyzing variations in the z-average diameter and zeta potential, we were able to establish the Krafft point, a parameter that remains imperceptible when polystyrene nanoparticles are absent from the solution.

2023-02-01·NeuroReport

Silent information regulator 1 mediates H2S-inhibited chronic restraint stress-induced depressive-like behaviors by regulating hippocampal autophagy

Article

作者: Tang, Yi-Yun ; Zou, Wei ; Jiang, Jia-Mei ; Luo, Bang ; Chen, Yong-Jun ; Chen, Lei ; Du, Lv ; Zhang, Ping

ObjectivesOur previous study has demonstrated that hydrogen sulfide (H2S), a novel gasotransmitter, attenuates excessive autophagy and depressive-like behaviors in chronic restraint stress (CRS)-exposed rats, but the underlying molecular mechanism remains to be elucidated. Silent information regulator 1 (SIRT1), a deacetylase at the consumption of NAD+ plays an important regulatory role in depression. Hence, this study aimed to investigate whether SIRT1 mediates the protective effect of H2S on CRS-induced depressive-like behaviors by regulating hippocampal autophagy.MethodsAdult male Sprague-Dawley (SD) rats were subjected to CRS (6 h × 28 days) to induce depression-like behavior. Rats were injected with sodium hydrosulfate (NaHS, 100 μmol/kg/d, i.p.), as a donor of H2S, alone or in combination with Sirtinol (a SIRT1 inhibitor; 10 nmol, i.c.v.) during CRS process. The depression-like characteristics of rats were assessed by the novelty-suppressed feeding test (NSFT), tail suspension test (TST), forced swimming test (FST) and open field test (OFT). The number of hippocampal autophagosomes was detected by transmission electron microscopy. The expressions of hippocampal autophagy-related proteins were measured by western blotting analysis.ResultsSirtinol blocked the inhibitory effect of H2S on depressive-like behaviors in CRS-exposed rats according to NSFT, TST, FST and OFT. In addition, sirtinol reversed the protective response of H2S to CRS-induced excessive autophagy, as proved by the increases in the number of autophagosomes and the expression of Beclin-1 as well as a decrease in the expression of P62 in the hippocampus.ConclusionThese results indicated that SIRT1 contributes to the antidepressant-like function of H2S during CRS via reducing hippocampal autophagy.

100 项与亚硝酸钠/硫代硫酸钠相关的药物交易

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