作者: Vargas‐Moreno, Vanessa Felipe ; Bonfante, Estevam Augusto ; Marcello‐Machado, Raissa Micaella ; Gomes, Rafael Soares ; Ribeiro, Michele Costa de Oliveira ; Bergamo, Edmara Tatiely Pedroso ; Del Bel Cury, Altair Antoninha

ABSTRACTThis study evaluated the reliability, failure mode, and stress distribution of wide‐diameter extra‐short dental implants (ESDI) as support for single crowns (SC) and fixed partial dentures (FPD) (3:1 crown‐to‐implant ratio [C:I]) for rehabilitation in the posterior atrophic mandible. For that, 126 ESDI (of 5 mm length) were allocated in four groups based on diameter (Ø4 and Ø6 mm) and prostheses (SC and FPD): SC4, SC6, FPD4, and FPD6. The fatigue test was performed by step‐stress accelerated life testing (n = 21/group), failure mode by fractographic analysis, and stress distribution by finite element analysis: von Mises stress (σvM), maximum shear stress (τmax), and minimum principal stress (σmin). Reliability at 200 N was higher than 84% in both SC4 and SC6, with SC6 showing significantly higher reliability at 300 N. Failure mode involved the abutment (SC4 and SC6). The missions were suspended for the FPD groups due to 100% survival at the maximum load. The σvM showed a stress reduction of about 40% at the SC6 implant when compared to SC4 and FPD6 compared to FPD4. For the abutment, a minor decrease of at least 6.72% was observed comparing SC6 to SC4 and 2.78% for the FPD6 compared to FPD4. The τmax and σmin in the cortical bone demonstrated a stress reduction of at least 38.85% for the SC6 compared to SC4 and at least 3.78% in FPD6 compared to FPD4. The σmin in the cancellous bone showed an overall reduction of at least 8.46% for SC6 compared to SC4 and for FPD6 compared to FPD4. But, for τmax, in the cancellous bone, a 19.42% higher stress was found in SC6 compared to SC4 and 27.21% in FPD6 compared to FPD4. Finally, when splinting was used, a general stress reduction was found, about 50% in both diameters in the implant and abutment. According to the limitations of this in vitro study, it is possible to conclude that both groups (SC4 and SC6) showed high reliability in clinically relevant loads for the posterior atrophic mandible, SC6 having the lowest probability of failure at 300 N, with failure restricted to the abutment. Meanwhile, FPD6 has better stress distribution.

2025-03-01·Bioresource Technology

Techno-economic assessment of digestate management for full-scale continuous dry anaerobic digestion plant

Article

作者: Arıkan, Osman Atilla ; Guven, Huseyin ; Dereli, Recep Kaan ; Musluoğlu, Ahmet ; Maçin, Kadriye Elif

This study investigated techno-economic analysis of digestate management systems for a full-scale continuous dry anaerobic digestion plant treating organic fraction of municipal solid waste (OFMSW). A three-stage dewatering system was considered as the baseline scenario (Sc-1) whereas nitrogen removal unit (Sc-2), the incorporation of membrane bioreactor with nitrification downstream (Sc-3) and direct thermal drying of the digestate (Sc-4) were evaluated. The capital cost for the dewatering system with a cake dryer was $4.2 million. For Sc-2, NH₄-N load could be reduced by 60% and Sc-3 would allow for further reduction in COD and NH₄-N loads with capital cost of $5.2 and $9.1 million, respectively. To achieve an additional reduction in TN load, an investment of $9.8 million was required in Sc-4. Sc-1 had the lowest operation cost, consequently resulting in the highest income of $22.6/ton, whereas Sc-4 had the highest operation cost, resulting in the lowest income of $16.6/ton OFMSW.

2025-02-13·Journal of Medicinal Chemistry

Small Molecule Modulators of AMP-Activated Protein Kinase (AMPK) Activity and Their Potential in Cancer Therapy

Review

作者: Strang, Juliet E. ; Astridge, Daniel D. ; Reigan, Philip ; Nguyen, Vu T.

AMP-activated protein kinase (AMPK) is a central mediator of cellular metabolism and is activated in direct response to low ATP levels. Activated AMPK inhibits anabolic pathways and promotes catabolic activities that generate ATP through the phosphorylation of multiple target substrates. AMPK is a therapeutic target for activation in several chronic metabolic diseases, and there is increasing interest in targeting AMPK activity in cancer where it can act as a tumor suppressor or conversely it can support cancer cell survival. Small molecule AMPK activators and inhibitors have demonstrated some success in suppressing cancer growth, survival, and drug resistance in preclinical cancer models. In this perspective, we summarize the role of AMPK in cancer and drug resistance, the influence of the tumor microenvironment on AMPK activity, and AMPK activator and inhibitor development. In addition, we discuss the potential importance of isoform-selective targeting of AMPK and approaches for selective AMPK targeting in cancer.

100 项与 SC-4 相关的药物交易

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