4区 · 医学
Article
作者: Braje, Wilfried ; Kling, Andreas ; King, Linda L. ; Haupt, Andreas ; Delzer, Juergen ; Teschendorf, Hans-Juergen ; Hutchins, Charles W. ; Backfisch, Gisela ; Geneste, Herve ; Wernet, Wolfgang ; Unger, Liliane
The synthesis and SAR of novel highly potent and selective dopamine D(3)-receptor antagonists based on a 1H-pyrimidin-2-one scaffold are described. A-690344 antagonized PD 128907-induced huddling deficits in rat (ED(50) 6.1mg/kg po), a social interaction paradigm.