The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic function.

开始日期2024-01-01

申办/合作机构

VA Office of Research and Development

100 项与 Vertebral Bone Marrow-Mesenchymal Stem Cells(VA Office of Research and Development) 相关的临床结果

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100 项与 Vertebral Bone Marrow-Mesenchymal Stem Cells(VA Office of Research and Development) 相关的转化医学

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100 项与 Vertebral Bone Marrow-Mesenchymal Stem Cells(VA Office of Research and Development) 相关的专利（医药）

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项与 Vertebral Bone Marrow-Mesenchymal Stem Cells(VA Office of Research and Development) 相关的文献（医药）

2024-10-01·Journal of Antimicrobial Chemotherapy

Biliary pharmacokinetic/pharmacodynamic analysis of continuous infusion meropenem/vaborbactam in a case series of orthotopic liver transplant recipients

Article

作者: Siniscalchi, Antonio ; Gatti, Milo ; Viale, Pierluigi ; Laici, Cristiana ; Ambretti, Simone ; Rinaldi, Matteo ; Pea, Federico

AbstractObjectiveTo analyse the biliary pharmacokinetics/pharmacodynamics (PK/PD) of continuous infusion (CI) meropenem-vaborbactam (MEM-VBM) in a case series of orthotopic liver transplant (OLT) recipients being treated for Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) related biliary tract infections (BTIs) or as preemptive therapy of KPC-Kp rectal colonization.MethodsCritical OLT recipients receiving CI MEM-VBM (2 g/2 g q8h over 8 h) because of KPC-Kp related BTIs or as preemptive therapy of KPC-Kp rectal colonization, having Kehr’s tube positioned and undergoing simultaneous therapeutic drug monitoring of MEM and VBM in plasma and bile were retrospectively assessed. Bile-to-plasma ratio of free steady-state concentrations (fCss) of MEM and VBM was used for assessing biliary penetration. Optimal joint MEM-VBM PK/PD target attainment was defined as MEM fCss/MIC ratio >4 coupled with VBM free area under time–concentration curve (fAUC)/threshold concentration (CT) ratio >24.ResultsOverall, four critical OLT recipients were included. Median bile-to-plasma ratio was 0.32 for MEM (range 0.21–0.79) and 0.40 for VBM (range 0.20–0.77). Biliary MEM-VBM joint PK/PD target attainment was optimal in 3/4 OLT recipients and quasi-optimal in the other one.ConclusionsThe 1:1 proportion between MEM and VBM concentrations was maintained unchanged in the bile, allowing us to assume that the efficacy of MEM-VBM may be appropriate even in the treatment of BTIs. CI administration was an effective strategy for attaining aggressive biliary joint PK/PD targets against pathogens with an MIC up to 2 mg/L.

2024-08-01·Journal of Pharmaceutical and Biomedical Analysis

Discovery and verification of antidepressant active ingredients of raw and vinegar-processed Bupleurum marginatum var. Stenophyllum based on plant metabolomics and serum pharmacology

Article

作者: Qu, Zhongyuan ; Zhao, Junyi ; Zou, Xiang ; Wang, Jinhong ; Wang, Hao ; Bing, Yifan ; Ji, Xiaoling ; Wu, Shuang

The dried root of Bupleurum marginatum var. stenophyllum (H. Wolff) R.H. Shan & Y. Li (BM), which has been used as a Bupleuri radix in Guizhou Province and is listed in the 2003 edition of the Guizhou Quality Standard for Traditional Chinese Medicines and Ethnic Materia Medica, is effective at dispersing the liver and relieving depression and often used in the form of raw or vinegar-processed product (VBM). However, the potential depression-relieving components of BM are unclear. The aim of this study was to determine the potential antidepressant constituents of BM and investigate the effect of vinegar processing on these components. The antidepressant effect and mechanism of BM and VBM were investigated in depressed mice and BV2 cells, respectively. The pharmacodynamic constituents were screened through serum pharmacochemistry, which combined the results of metabolomics analysis of BM and VBM, high-performance liquid chromatography (HPLC) content determination, and verification of the antidepressant effect and mechanism of differential components of SSb₂ to clarify the connotation of vinegar processing. Our results demonstrated that BM can exert a significant antidepressant effect by inhibiting microglia polarization and that this effect was enhanced after vinegar processing. Thirty-eight components were identified in the BM, 13 of which were blood-absorbable, mainly saponins, and defined as potential antidepressant components of the BM. The contents of 17 components-6 of which were absorbed into the blood-changed considerably after processing. It was finally determined that vinegar processing can enhance the antidepressant effect of BM by increasing the contents of SSb₁ and SSb₂. SSb₂ exerts this effect via the samemechanism as BM. In conclusion, in this study we clarified the antidepressant effects and potential active components of BM and examined the mechanism of vinegar processing. These findings lay a foundation for the future research on the antidepressant effects of BM as well as for the complete development and application of BM's ethnomedicinal resources.

2024-07-01·Archiv der Pharmazie

Metabolic profiling of Verbena bonariensis L. extract by LC/MS and evaluation of the hepatoprotective potential with isoniazid‐ and rifampicin‐induced hepatotoxicity in rats

Article

作者: Rehman, Saira ; Elhady, Sameh S. ; Kamran, Sairah Hafeez ; Ishtiaq, Saiqa ; Albaik, Mai ; Akhtar, Zahid Mehmood

AbstractThe study explored the hepatoprotective activity and metabolic profile of Verbena bonariensis L. methanol extract (VBM) and fractions using isoniazid as well as rifampicin‐triggered liver toxicity in Wistar albino rats. Metabolite profiling of VBM using HPLC‐PDA‐ESI‐MS identified 12 compounds, mainly iridoids, phenylpropanoids, and flavonoids, where verbascoside represents the major compound. Different biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), bilirubin, and total protein levels were used to assess liver functions. All the evaluated samples exhibited hepatoprotective potential, but VBM exhibited maximum activity and a notable decline in ALP (p < 0.05, significant), even better than the standard drug (silymarin). VBM significantly reduced the elevated ALT, AST, ALP, and total bilirubin. It also triggered a significant elevation in total proteins compared with diseased animals. This was further consolidated by histopathological studies. Verbena bonariensis L. could serve as a potent hepatoprotective agent and may alleviate liver ailments.

100 项与 Vertebral Bone Marrow-Mesenchymal Stem Cells(VA Office of Research and Development) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
衰弱症	临床2期	美国	VA Office of Research and Development	2022-07-15
慢性胰腺炎	临床1期	美国	VA Office of Research and Development	2023-06-29