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更新于：2025-03-20

Ketazolam

凯他唑仑

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

Ketazolam (USAN/INN)

+ [5]

靶点

GABAA receptor

作用方式

激动剂

作用机制

GABAA receptor激动剂(γ-氨基丁酸 A 受体激动剂)

治疗领域

其他疾病

在研适应症

焦虑症

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C20H17ClN2O3

InChIKeyPWAJCNITSBZRBL-UHFFFAOYSA-N

CAS号27223-35-4

关联

100 项与凯他唑仑相关的临床结果

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100 项与凯他唑仑相关的转化医学

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100 项与凯他唑仑相关的专利（医药）

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156

项与凯他唑仑相关的文献（医药）

2024-07-09·ACS Omega

Integrated ML-Based Strategy Identifies Drug Repurposing for Idiopathic Pulmonary Fibrosis

Article

作者: Bae, Myung Ae ; Samantasinghar, Anupama ; Ahmed, Faheem ; Choi, Kyung Hyun

Idiopathic pulmonary fibrosis (IPF) affects an estimated global population of around 3 million individuals. IPF is a medical condition with an unknown cause characterized by the formation of scar tissue in the lungs, leading to progressive respiratory disease. Currently, there are only two FDA-approved small molecule drugs specifically for the treatment of IPF and this has created a demand for the rapid development of drugs for IPF treatment. Moreover, denovo drug development is time and cost-intensive with less than a 10% success rate. Drug repurposing currently is the most feasible option for rapidly making the drugs to market for a rare and sporadic disease. Normally, the repurposing of drugs begins with a screening of FDA-approved drugs using computational tools, which results in a low hit rate. Here, an integrated machine learning-based drug repurposing strategy is developed to significantly reduce the false positive outcomes by introducing the predock machine-learning-based predictions followed by literature and GSEA-assisted validation and drug pathway prediction. The developed strategy is deployed to 1480 FDA-approved drugs and to drugs currently in a clinical trial for IPF to screen them against "TGFB1", "TGFB2", "PDGFR-a", "SMAD-2/3", "FGF-2", and more proteins resulting in 247 total and 27 potentially repurposable drugs. The literature and GSEA validation suggested that 72 of 247 (29.14%) drugs have been tried for IPF, 13 of 247 (5.2%) drugs have already been used for lung fibrosis, and 20 of 247 (8%) drugs have been tested for other fibrotic conditions such as cystic fibrosis and renal fibrosis. Pathway prediction of the remaining 142 drugs was carried out resulting in 118 distinct pathways. Furthermore, the analysis revealed that 29 of 118 pathways were directly or indirectly involved in IPF and 11 of 29 pathways were directly involved. Moreover, 15 potential drug combinations are suggested for showing a strong synergistic effect in IPF. The drug repurposing strategy reported here will be useful for rapidly developing drugs for treating IPF and other related conditions.

2024-01-01·Results in Chemistry

Edge-based metric resolvability of anti-depression molecular structures and its application

作者: Azeem, Muhammad ; Nawaz, Rab ; Jamil, Muhammad Kamran

Chem. graph theory represents an interdisciplinary field at the intersection of chem. and mathematics, focusing on the anal. of various chem. structures through graph-theor. frameworks.This area facilitates the examination of complex and extensive chem. configurations by leveraging graph theory principles.In chem. structure graphs, atoms are depicted as vertices, with edges representing the bonds between them.By employing chem. graph theory, the exploration of diverse drug compounds and intricate mol. structures becomes more manageable.A key concept in this field is the resolvability parameter, a metric derived from graph theory.It stipulates that each vertex in a structure must possess a distinct representation via elected vertices, known as a metric basis, resolving set, or locating set in different scientific contexts.The metric dimension, defined as the min. number of vertices in the resolving set, plays a crucial role in characterizing the structural properties of chem. graphs.In this study, we discussed the edge metric dimension of structures of benzodiazepines, alprazolam, chlordiazepoxide, clobazam, clonazepam, diazepam, nitrazepam, lolendazam, alferez, which are types of drug that used for the treatment of depression.We also put to use the edge metric dimension in anti-depression chem. structures, which are different types of Benzodiazepine.For application of this topic, we select the hospitals and health centers in any emergency situation.In any chronic disease situation, these chosen health centers provide all medical facilities to other hospitals efficiently only because we assigned each hospital and health center a unique code.

2022-09-01·Drug and Alcohol Dependence

Five-year incidence of substance use and mental health diagnoses following exposure to opioids or opioids with benzodiazepines during an emergency department encounter for traumatic injury

Article

作者: Kaelber, David C ; Johnson, Keilan ; Lewis, Daniel ; Winhusen, T John ; Sprunger, Joel G

BACKGROUNDBenzodiazepines and opioids are used alone or in conjunction in certain care settings, but each have the potential for misuse.OBJECTIVEThis longitudinal observational study evaluated substance use and mental health outcomes associated with providing opioids with or without benzodiazepine to treat traumatic injury in the emergency department (ED) setting.METHODSWe analyzed a limited dataset obtained through the IBM Watson Health Explorys. Matched cohorts were defined for: 1) patients treated with opioids during the ED encounter (ED-Opioid) vs. neither opioid or benzodiazepine treatment (No medication) (n = 5372); 2) patients treated with opioids and benzodiazepines during the ED encounter (ED-Opioid+Benzodiazepines) vs. No Medication (n = 2454); and 3) ED-Opioid+Benzodiazepines vs. ED-Opioid (n = 2454). Patients consisted of adults with an emergency department encounter in the MetroHealth System (Cleveland, Ohio) with a chief complaint of traumatic injury and medical records for five years following the encounter. Control patients for each cohort were matched to the exposure patients on demographics, body mass index, and residential zip code median income. Outcomes were five-year incidence rates for alcohol, substance use, depression, and anxiety-related diagnoses.RESULTSOur results indicate that, although receiving opioids during the ED visit predicted a relatively lower likelihood of subsequent substance use and mental health diagnoses, the brief co-use of benzodiazepines was strongly associated with poorer outcomes.CONCLUSIONSEven brief exposure to co-prescribed opioids and benzodiazepines during emergency traumatic injury care may be associated with negative substance use and mental health consequences in the years following the event.

100 项与凯他唑仑相关的药物交易

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