The purpose of this study is to determine if glucose peaks higher and earlier after a meal when a patient is given intranasal insulin instead of conventional insulin treatment.

开始日期2009-07-01

申办/合作机构

CPEX Pharmaceuticals, Inc.

100 项与 Transbuccal insulin(Midatech Pharma US, Inc.) 相关的临床结果

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100 项与 Transbuccal insulin(Midatech Pharma US, Inc.) 相关的转化医学

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100 项与 Transbuccal insulin(Midatech Pharma US, Inc.) 相关的专利（医药）

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项与 Transbuccal insulin(Midatech Pharma US, Inc.) 相关的文献（医药）

2017-10-01·Journal of Controlled Release1区 · 医学

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

1区 · 医学

Review

作者: Al-Salami, Hani ; Dass, Crispin R ; Wong, Chun Y

Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin. Firstly, the structure and physiological function of insulin are examined. Then, the efficiency and shortcomings of insulin nanoparticle are discussed. These include the susceptibility to digestive enzyme degradation, instability in the acidic pH environment, poor mucus diffusion and inadequate permeation through the gastrointestinal epithelium. In order to optimise the nanocarriers, the following considerations, including polymer nature, surface charge, size, polydispersity index and morphology of nanoparticles, have to be taken into account. Some novel designs such as chitosan-based glucose-responsive nanoparticles, layer by layer technique-based nanoparticles and zwitterion nanoparticles are being adopted to overcome the physiological challenges. The review ends with some future directions and challenges to be addressed for the success of oral delivery of insulin-loaded nanoparticle formulation.

2014-09-22·Current Pharmaceutical Biotechnology4区 · 医学

Intestinal Uptake of Insulin Nanoparticles: Facts or Myths?

4区 · 医学

Review

作者: Veiga, Francisco ; Abrahim, Barbara A. ; Rodrigues, Carlos R. ; Ribeiro, Antonio J. ; Lopes, Marlene A. ; Seica, Raquel

The oral route is the most suitable and physiological delivery route. Oral insulin delivery would minimize the health hazard implied in repeated injection, surpass complications arising from the need for sterile techniques associated with parenteral formulations and provide better glucose homeostasis. However, it is limited by various physiological barriers and still remains a scientific challenge. The desire to deliver insulin by the oral route in a conveniently and effectively way has led to the intense investigation of new delivery systems. Nanodelivery systems have been proposed to enhance the bioavailability of insulin after oral administration. This review article describes the gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers. The potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are also addressed. Finally, how nanoparticles characteristics affect insulin pharmacological activity and bioavailability is discussed.

2012-03-01·Journal of Microencapsulation4区 · 医学

Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by¹³C and²H isotopomer analysis

4区 · 医学

Article

作者: Patrícia Nunes ; Christiane Damgé ; Rui A Carvalho ; Ronald Neufeld ; Ana F Soares ; Isabel V Figueiredo ; Catarina Pinto Reis ; John Jones ; Francisco Veiga

The purpose of this study was to evaluate hepatic glucose metabolism of diabetic induced rats after a daily oral load of insulin nanoparticles over 2 weeks. After the 2-week treatment, an oral glucose tolerance test was performed with [U-¹³C] glucose and ²H₂O. Plasma glucose ²H and ¹³C enrichments were quantified and the contribution of glycogenolysis and gluconeogenesis to overall glucose production were estimated. Animals with the insulin nanoparticles displayed the lowest glycemia before the oral glucose tolerance test. In all animals, 75% of the total glucose production was from gluconeogenesis and glycogen synthesis was only detected in some animals. Gluconeogenic pathway was an active contributor to hepatic glucose production and the treatment with oral delivered insulin nanoparticles did not alter this contribution, suggesting that under this treatment, protocol hepatic glucose metabolism is not the most relevant target of insulin action but instead a more generalised effect in peripheral tissues.

100 项与 Transbuccal insulin(Midatech Pharma US, Inc.) 相关的药物交易

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