This is a pilot study to assess the correlation between urinary pH and Interstitial Cystitis (IC) pain, with emphasis placed on exploring the type and severity of pain.

开始日期2016-02-01

申办/合作机构

St. Louis University

100 项与甲磺酸二甲替嗪相关的临床结果

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100 项与甲磺酸二甲替嗪相关的转化医学

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100 项与甲磺酸二甲替嗪相关的专利（医药）

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项与甲磺酸二甲替嗪相关的文献（医药）

1998-01-01·Folia Pharmacologica Japonica

ラット海馬スライスにおけるＳｐｒｅａｄｉｎｇ　ｄｅｐｒｅｓｓｉｏｎに対する新規カルシウムきっ抗薬ＫＢ‐２７９６の作用

Article

作者: Mizuo Takashima ; Hiroshi Takagi ; S.Y. Liou

KB-2796, a novel calcium channel blocker, is under development as an anti-migraine drug. We examined its effects on spreading depression (SD) in rat hippocampal slices as compared with those of flunarizine, dimetotiazine and sumatriptan. Extracellular recording was made from the CA1 subfield. An SD, followed by a series of spontaneous SDs, was induced by a brief period of hypoxia (40-60 sec). The latency of initiated SD and the interval between the initiated and subsequent spontaneous SDs were examined. KB-2796 significantly prolonged both latency and interval in a concentration-dependent manner (10(-10)-10(-8) M). KB-2796 was about 1,000 and 10 times more potent than flunarizine in prolonging the latency and interval, respectively. However, dimetotiazine and sumatriptan did not show any activity at 10(-7) and 10(-6) M. the effect of KB-2796 on SD may be due to their calcium channel blocking effects.

1997-07-01·Research communications in molecular pathology and pharmacology

Effects of KB-2796 on plasma extravasation following antidromic trigeminal stimulation in the rat.

Article

作者: Yamamoto, Y ; Takagi, H ; Hashimoto, M

We investigated the effects of KB-2796 (1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride), a novel calcium channel blocker, on neurogenic inflammation caused by electrical stimulation in the trigeminal ganglion and on cutaneous reactions induced by inflammatory mediators in rats, by measuring plasma extravasation. Neurogenic inflammation was inhibited by pretreatment with capsaicin (25 mg/kg, s.c.) but not indomethacin (10 mg/kg, i.p.), while phosphoramidon (2.5 mg/kg, i.v.) augmented it. KB-2796 (0.1-1 mg/kg, i.v.) significantly inhibited neurogenic inflammation in a dose dependent manner, without affecting histamine-, bradykinin- or substance P-induced cutaneous reactions. Dimetotiazine (0.3 and 1 mg/kg, i.v.), flunarizine (1 mg/kg, i.v.), mepyramine (1 mg/kg, i.v.) and sumatriptan (1 mg/kg, i.v.) significantly inhibited neurogenic inflammation. However, these compounds also showed complete or partial inhibition of histamine-, bradykinin- or substance P-induced reactions. Nifedipine (0.1 mg/kg, i.v.) did not show marked effects on neurogenic inflammation and cutaneous reactions. The present experiments indicate that neurogenic inflammation is presumably mediated not only by neuropeptides released from trigeminal nerve endings but also by secondarily released histamine, and that KB-2796 like sumatriptan may inhibit neurogenic inflammation caused by trigeminal nerve stimulation probably through inhibition of neuropeptide release but its inhibition may be distinct from the calcium blocking action of the 1,4-dihydropyridine type.

1997-01-01·The Japanese Journal of Pharmacology

Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca2+-Channel Blocker, on Ba2+ Current through Voltage-Gated Ca2+ Channels in PC12 Cells.

Article

作者: Hideaki Hara ; Takayuki Sukamoto ; Tomokazu Watano

We investigated the effect of lomerizine, an anti-migraine drug, on the Ba2+ current through voltage-gated Ca2+ channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba2+ current with an IC50 value of 1.9 microM. Lomerizine and nicardipine were >4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca2+ channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine.

100 项与甲磺酸二甲替嗪相关的药物交易

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