脂斑清胶囊(Zhibanqing Capsule) - 在研适应症：高脂血症_专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症

高脂血症

非在研适应症-

原研机构-

在研机构

山西省中医药研究院（山西省中医院）北京凯晋科技有限公司

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)临床3期

特殊审评-

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关联

1

项与脂斑清胶囊相关的临床试验

CTR20140313 / Recruiting临床3期

脂斑清胶囊治疗高脂血症（痰瘀互结证）临床安全性、有效性、随机、双盲、安慰剂对照，多中心III期临床试验

通过III期临床试验，进一步评价脂斑清胶囊治疗高脂血症（痰瘀互结证）的临床安全性与有效性。

开始日期2014-05-06

申办/合作机构

山西省中医药研究院（山西省中医院）

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100 项与脂斑清胶囊相关的临床结果

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100 项与脂斑清胶囊相关的转化医学

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100 项与脂斑清胶囊相关的专利（医药）

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1

项与脂斑清胶囊相关的文献（医药）

2008-03-15·Journal of Chinese Integrative Medicine

Amelioration effect of Zhenqing Capsule on peripheral neuropathy in type 1 diabetic rats

Article

作者: Wen, Xiu-ying ; Hu, Qin-jin ; Wang, Fang

OBJECTIVETo investigate the effects of Zhenqing Capsule (ZQC), a compound traditional Chinese herbal medicine, in treating type 1 diabetic rats with peripheral neuropathy.METHODSType 1 diabetes was induced by caudal vein injection of high-dose streptozotocin in 30 male Wistar rats. The thirty diabetic rats were randomly divided into three groups: ZQC-treated group, untreated group and aminoguanidine-treated group. Another group of 10 rats was taken as normal control. After 10-week treatment, the changes of body weight and fasting plasma glucose level were measured, and the serum MDA level and the changes of neurological electrophysiology were analyzed. The samples of sciatic nerve in diabetic rats were taken for morphological observation.RESULTSThe MDA level in type 1 diabetic rats was notably reduced in ZQC-treated group as compared with the untreated group (P<0.01). Compared with the untreated group, ZQC could improve the electrophysiology of sciatic nerve including conduction velocity (P<0.05), latency (P<0.01) and wave amplitude (P<0.05). The nerve myelin staining results showed that segmental demyelination of the nerve fibers in ZQC-treated group was not as serious as that in the untreated group.CONCLUSIONZQC can obviously ameliorate the neurological electrophysiological function and the pathological changes of peripheral nerve in type 1 diabetic rats through the removal of free radical and resistance of lipid peroxidation.

100 项与脂斑清胶囊相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
高脂血症	临床3期	中国	北京凯晋科技有限公司	2014-05-06
高脂血症	临床3期	中国	山西省中医药研究院（山西省中医院）	2014-05-06