焦磷酸钠(Sodium pyrophosphate) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

Angiocis

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病遗传病与畸形血液及淋巴系统疾病+ [2]

在研适应症-

非在研适应症

结石弹性假黄瘤

原研机构-

在研机构-

非在研机构

Bangalore Medical College & Research Institute

Tampere University Hospital

权益机构-

最高研发阶段终止临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式H4Na4O7P2

InChIKeyWTXQIGCNRZDSJU-UHFFFAOYSA-N

CAS号7722-88-5

关联

2

项与焦磷酸钠相关的临床试验

NCT04441671

/ Withdrawn临床2期IIT

Oral Disodiumpyrophosphate (Na2H2PPi) Absorption in Pseudoxanthoma Elasticum (PXE)

Pyrophosphate is an endogenous, non-toxic metabolite inhibiting soft tissue calcification. The aim of our study is to find optimal dosing and safety of oral disodium-PPi (Na2H2PPi). Absorption curves (pharmacokinetics), AUC0-t, Cmax and Tmax for PPi and phosphate will be provided for healthy controls and PXE-patients both fasting and with standard meal intake.

开始日期2020-12-08

申办/合作机构

Tampere University Hospital

[+2]

NCT02869308

/ Unknown statusN/AIIT

Determination of Left Ventricular Ejection Fraction Using Cardiac Angioscintigraphy: Comparison Between Measurements Obtained With Conventional Planar Scintigraphy (E-CAM Camera) and Tomoscintigraphy Recorded by a CZT Semiconductor Camera (D-SPECT)

The purpose is to determine whether measurements of left ventricular ejection fraction (LVEF) obtained with angiographies recorded by conventional Anger camera or D-SPECT camera are equivalent.
Secondary purposes are:
To evaluate the influence of cardiac activity recorded by D-SPECT camera on equivalences defined in primary purpose
To evaluate the influence of the indication for the examination with a distinct analysis of a group having the examination for a known or suspected cardiomyopathy (LVEF often abnormally low) and a group having the examination for a chemotherapy supervision with heart initially considered healthy (LVEF often normal).

开始日期2014-01-01

申办/合作机构

Centre Hospitalier Regional de Nancy

100 项与焦磷酸钠相关的临床结果

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100 项与焦磷酸钠相关的转化医学

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100 项与焦磷酸钠相关的专利（医药）

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4,800

项与焦磷酸钠相关的文献（医药）

2025-09-01·Talanta

A β-cyclodextrin/porous graphene ink electrode for smartphone-assisted electrochemical Hg2+ sensing

Article

作者: Sanguarnsak, Chanakarn ; Somapa, Dongsayam ; Promsuwan, Kiattisak ; Saisahas, Kasrin ; Samoson, Kritsada ; Saichanapan, Jenjira ; Somapa, Namchoke ; Witoolkollachit, Polawat ; Limbut, Warakorn ; Soleh, Asamee ; Wangchuk, Sangay

A novel portable electrochemical sensor for Hg²⁺ detection was developed, featuring integration with a smartphone-based potentiostat and utilizing a β-cyclodextrin-coated porous graphene ink-modified screen-printed electrode (β-CD/P-Gi/SPE). The use of β-cyclodextrin enhances molecular recognition and selectivity for Hg²⁺, while porous graphene ink improves conductivity and sensitivity, addressing limitations of existing electrode materials. Comprehensive characterization using SEM, EDX, FT-IR, and Raman spectroscopy confirmed the successful incorporation of the β-CD polymer film onto the P-Gi. The electrochemical properties of the modified electrode were evaluated using electrochemical impedance spectroscopy and cyclic voltammetry. The adsorptive anodic stripping voltammetry (AdASV) condition was also optimized. Under optimal conditions, AdASV demonstrated that the oxidation peak current was linearly proportional to the Hg²⁺ concentration in the range of 0.50-80 μg mL^-1 with a detection limit of 0.11 μg mL^-1. Furthermore, the sensor exhibited excellent reproducibility, sustained long-term stability, and a fast current response. To demonstrate the practical applicability of the proposed sensor, the proposed sensor successfully determined Hg²⁺ in skin whitening creams.

2025-06-01·Journal of Hazardous Materials

Bioavailability, migration and driving factors of As, Cd and Pb in calcareous soil amended with organic fertilizer and manganese oxidizing bacteria in arid northwest China

Article

作者: He, Liang ; Long, Song ; Wang, Shengli ; Ning, Xiang

Organic matter, serving as a carbon source and energy provider for microbial activities driving manganese oxidation in soil, plays a vital role in the biogeochemical processes underlying the formation of biological manganese oxides (BMOs) and regulating heavy metal (HMs) mobility within soil profiles. The interactions between BMOs and organic matter, their environmental behavior, and practical field applications remain poorly understood. In this study, the remediation effectiveness of organic fertilizer (OF) and manganese-oxidizing bacteria (B) in addressing arsenic (As), cadmium (Cd), and lead (Pb) co-contamination in soil was evaluated, alongside the resulting elemental migration within the soil profile, uptake by maize, and post-remediation soil health. A 400-day field experiment demonstrated that compared with the control, treatment with 1.0 % organic fertilizer promoted the transformation of HMs chemical form from relatively active to stable fraction, significantly controlling Cd and Pb accumulation in maize roots (p < 0.05). Conversely, treatment of B decreased the bioavailability of As by 23.9 % but increased the bioavailability of Cd and Pb by 10.9 % and 20.2 %, respectively. Thus, it significantly increased Pb content in leaves and additional attention should be paid to its feed and food health risks. Under the combined BOF treatment (bacteria + organic fertilizer), high fixation efficiency of As (42.3 %), Cd (16.8 %), and Pb (13.2 %) was achieved through chemical transformation, reduced leaching risks, break the nucleation spatial locations, and the microbial-mineral pump mechanism. BOF treatment also significantly increased the relative abundance of Actinomycetes (+15.8 %) and Proteobacteria (+13.3 %) at the phylum level, suggesting those microorganisms possibly were persistently recruited in biomineralization nucleation. Soil enzyme activity analysis revealed that only treatment B reduced sucrase activity, while urease and catalase activities were not significantly affected in any treatment. Principal component analysis indicated that pH was a critical environmental driver of the biogeochemical cycling of Cd and Pb. Furthermore, maize absorption of nutrients such as iron and phosphorus influenced the transport and mobility of HMs. This study highlights the effectiveness of BOF treatment in simultaneously stabilizing As, Cd, and Pb, while enhancing the adaptability of in-situ remediation materials to the soil, making it a promising strategy for remediating HMs-contaminated soils.

2025-06-01·Hydrometallurgy

The role of P(V) salts in inhibiting CaCO3 precipitation in the uranium in-situ leaching process using CO2 and O2

作者: Zhou, Yipeng ; Yang, Lanzhi ; Xu, Lingling ; Kai, Zhao ; Li, Guangrong ; Ke, Pingchao ; Yang, Feifan

Addition of chem. agents to inhibit the CaCO₃ precipitation process is a potential way to solve the blocking problem in the industrial in situ leaching process for uranium recovery.This research investigated the role of P(V) added as sodium hexametaphosphate ((NaPO₃)₆), anhydrous sodium pyrophosphate (Na₄P₂O₇), and sodium tripolyphosphate (Na5P3O10) as inhibitors for the precipitation of CaCO₃ in supersaturated solutions of Ca²⁺ and HCO^-3.The results indicated that the three inhibitors prevented the formation and growth of CaCO₃ and Na₅P₃O₁₀ showed the best performance.In the aqueous phase Ca²⁺ coordinated with P(V) ions to form complex anions of Ca-phosphates including CaHP₂O^-₇, CaP₂O^2-₇, CaHP₃O₂^-₁₀, and CaP₃O₃^-₁₀.The role of P(V) as an inhibitor was attributed to the adsorption of P(V) species including Ca-P complex anions and phosphate anions on the calcite surface to form an amorphous protective layer which prevented further precipitation of CaCO₃ phase.Moreover, dosage threshold of Na₅P₃O₁₀ was exptl. determined to be 2 mg/L.This dosage gave a CaCO₃ precipitation inhibition efficiency higher than 90%.Injection of inhibitors had no neg. effect on the in situ leaching of uranium by CO₂ and O₂ and subsequent ion exchange adsorption process for uranium recovery.

100 项与焦磷酸钠相关的药物交易

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