预约演示

更新于：2025-05-07

Bacterial growth inhibitors(Riker Laboratories, Inc)

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid

靶点-

作用方式

抑制剂

作用机制

细菌生长抑制剂

治疗领域

感染

在研适应症-

非在研适应症

细菌感染

原研机构-

在研机构-

非在研机构

Riker Laboratories Ltd.

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Bacterial growth inhibitors(Riker Laboratories, Inc) 相关的临床结果

登录后查看更多信息

100 项与 Bacterial growth inhibitors(Riker Laboratories, Inc) 相关的转化医学

登录后查看更多信息

100 项与 Bacterial growth inhibitors(Riker Laboratories, Inc) 相关的专利（医药）

登录后查看更多信息

项与 Bacterial growth inhibitors(Riker Laboratories, Inc) 相关的文献（医药）

1987-05-01·Journal of Medicinal Chemistry1区 · 医学

Synthesis, absolute configuration, and antibacterial activity of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid

1区 · 医学

Article

作者: Olsen, Roger A. ; Gleason, William B. ; Pecore, Sharon E. ; Gerster, John F. ; Rohlfing, Steve R. ; Landmesser, June E. ; Stern, Richard M. ; Winandy, Richard M.

The tricyclic quinolone antibacterial agent 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine -2-carboxylic acid has an asymmetric center at position 5 of the molecule. The R and S isomers of the compound have been prepared from the corresponding (R)- and (S)-2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydroquinolines, which were separated via their diastereomeric amides of N-tosyl-(S)-proline. The absolute configuration was established by X-ray analysis of one of the diastereomeric amides. The 5-desmethyl analogue was prepared for antibacterial comparison with the isomers and the racemic mixture. It has now been established that the S isomer is much more active than the R isomer. The 5-desmethyl analogue was found to be more active than the R isomer but not as active as the S isomer or the racemic mixture. The importance of stereochemistry at position 5 in this system has been established.

1970-10-01·Journal of Clinical Pathology3区 · 医学

Role of bacterial growth inhibitors in urine in diagnostic culture

3区 · 医学

Article

作者: Ghosh, H. K.

Frequently no growth is obtained on ordinary cultures from urines of patients with typical symptoms of infection, and sometimes not even from those with pyuria. The possibility that this could be due to antibacterial substances—whether endogenous or exogenous from non-specific medication—has been investigated.

1952-09-01·Journal of Bacteriology3区 · 生物学

PATTERNS OF GROWTH INHIBITION

3区 · 生物学

Article

作者: Moore, A. M. ; Boylen, Joyce B.

Three different types of response to a bacterial growth inhibitor can be distinguished.In type 1 as exemplified by 5-bromouracil, the plot of log density against time is linear in agreement with the exponential growth law.The slopes of the curves, which are proportional to the rates of division, are altered by the inhibitor in the manner expected for inhibition of a reaction sequence in the steady state.The lack of delay in attaining the final growth rate suggests that the rate of penetration of such compounds into the cell is not a limiting factor in the degree of inhibition.Type 2 response, as represented by sulfanilamide, is more complex.The final growth rate is not reached until the cells have undergone 2 or 3 divisions.Perhaps the reason for the delay is that even if the synthesis of some enzyme is stopped, the existing mols. continue to function until destroyed by catabolic processes, or are diluted below an effective concentrationOr possibly very slow diffusion into the cell may be the explanation.The type 3 reaction, represented by pyridine-3-sulfonic acid, is still more complex.Results here depend markedly upon size of inoculum.No satisfactory explanation of this type of inhibition is known.

100 项与 Bacterial growth inhibitors(Riker Laboratories, Inc) 相关的药物交易

登录后查看更多信息