更新于：2024-11-01

Phenindamine Tartrate

酒石酸苯茚胺

更新于：2024-11-01

概要

概要

基本信息

药物类型

小分子化药

别名

Phenindamine、Phenindamine tartrate (USAN)、Thephorin

+ [1]

靶点

H1 receptor

作用机制

H1 receptor拮抗剂(组胺H1受体拮抗剂)

治疗领域

免疫系统疾病

在研适应症

超敏反应

非在研适应症-

原研机构

F. Hoffmann-La Roche Ltd.

在研机构

F. Hoffmann-La Roche Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C19H19N

InChIKeyISFHAYSTHMVOJR-UHFFFAOYSA-N

CAS号82-88-2

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关联

100 项与酒石酸苯茚胺相关的临床结果

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100 项与酒石酸苯茚胺相关的转化医学

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100 项与酒石酸苯茚胺相关的专利（医药）

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项与酒石酸苯茚胺相关的文献（医药）

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

The structure of phenindamine base and salts in the solute state

3区 · 医学

Article

作者: Branch, S K ; Upton, C ; Hussain, R ; Casy, A F

AbstractHigh-field NMR (13C and 1H) studies of phenindamine are reported which establish structures of the free base and some of its salts in the solute condition. The base exists as a mixture of two isomers which differ in double bond position (9–9a or 4a–9a) while most salts are 9–9a isomers. The clinically employed tartrate (Thephorin) is exceptional in being a 4a–9a ene. Salts of both double bond type exist in solution as mixtures of protonated epimers of variable epimeric ratio, that of the tartrate in D2O being approximately 1:1.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

The Identification and Determination of Nitrogenous Organic Bases with Ammonium Reineckate

3区 · 医学

Article

作者: Kum-Tatt, Lee

AbstractThe identification and determination of several important bases as their reineckates is described. The ultra-violet and visible spectra of reineckates were studied and used for the determination of molecular weights and solubilities and for the determination of bases. This paper also records as yet unreported constants of the characteristic mono- and di-reineckate derivatives of several clinically important compounds. A method for the regeneration of the conjugate bases from the reineckates using ion exchange resins is also given.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

THE EFFECT OF HISTAMINE AND ANTIHISTAMINES ON BODY TEMPERATURE

3区 · 医学

Article

作者: Rossi, G V ; Harrisson, J W E ; Packman, E W

Tests were made with histamine diphosphate and the following antihistamines: mepyramine-HCl, diphenhydramine-HCl, tripelennamine-HCl, promethazine-HCl (phenergan), phenindamine tartrate (thephorin), prophenpyridamine maleate, thonzylamine-HCl, 10-[2-(1-pyrrolidinyl)ethyl]phenothiazine-HCl (pyrathiazine-HCl), antazoline-HCl, thenylpyramine-HCl (methapyrilene), chlorocyclizine-HCl, 1-cyclohexylhexahydrobenzoic acid 2-diethylaminoethyl ester-HCl (dicyclomine-HCl), RP 3015, [2-(10-phenothiazinyl)isopropyl]trimethylammonium benzenesulfonate (thiazinamium), and RP 3550.Histamine and antihistamines cause a decrease in the body temperature of mice, rats, and guinea pigs, but they have no effect on the body temperature of rabbits.Antihistamines reduce the body temperature of normal animals as well as those with induced fever; therefore, the effect cannot be attributed to true antipyretic activity.There is no parallelism between the body temperature-decreasing effect of the antihistamines and their antihistaminic potency, antianaphylactic activity, atropine-like effect, hypnotic action, and acute toxicity.

100 项与酒石酸苯茚胺相关的药物交易

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