更新于：2024-11-21

Ethacizine

乙沙西嗪

更新于：2024-11-21

概要

概要

基本信息

药物类型

小分子化药

别名

Diethylamino-ethmozine、Etacizin、Ethacizin

+ [3]

靶点

SCNA

作用机制

SCNA阻滞剂(钠通道α亚基家族阻滞剂)

治疗领域

心血管疾病

在研适应症

心律失常

非在研适应症-

原研机构-

在研机构-

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C22H27N3O3S

InChIKeyPQXGNJKJMFUPPM-UHFFFAOYSA-N

CAS号33414-33-4

关联

100 项与乙沙西嗪相关的临床结果

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100 项与乙沙西嗪相关的转化医学

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100 项与乙沙西嗪相关的专利（医药）

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127

项与乙沙西嗪相关的文献（医药）

2020-12-01·European Heart Journal - Case Reports

A case of successful ablation of ventricular ectopic focus from the superior tricuspid annulus through the internal jugular vein: a case report

Article

作者: Hamrayev, Ramish ; Nedios, Sotirios ; Salayev, Oybek ; Sultankhonov, Sardorkhon

AbstractBackgroundSymptomatic premature ventricular complexes (PVCs) are a common clinical problem. Although most of ventricular ectopic foci can be easily ablated, some are very challenging and require special manoeuvers. This case report presents an approach to improve electrode stability during ablation.Case summaryA 19-year-old Asian male patient presented with frequent symptomatic PVCs having an inferior axis, left bundle branch morphology, and R/S transition in V4. Structural heart disease was excluded by echocardiography and general blood tests were normal. The treatment with a class Ic antiarrhythmic (ethacizine) over 2 months was ineffective and the patient was admitted for radiofrequency ablation. Activation mapping revealed a PVC focus in the superior part of the tricuspid annulus, but the femoral access approach resulted in frequent dislocation of the ablation tip. An internal jugular vein approach though resulted in improved stability and successful elimination of the PVC.DiscussionIn cases with PVCs from the superior portions of the right heart, stability of the electrode may be improved by a jugular venous access.

2020-02-01·Bulletin of Experimental Biology and Medicine4区 · 医学

Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia

4区 · 医学

Article

作者: Repenkova, L G ; Savelyeva, M I ; Svistunov, A A ; Polyakov, A V ; Kovachevich, I V ; Kukes, V G ; Kondratenko, S N

We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal conditions and on the second day of simulated antiorthostatic hypokinesia modeling some effects of microgravity. Under conditions of antiorthostatic hypokinesia, a tendency to a decrease in half-elimination period, mean retention time, and volume of distribution and an increase in the rate of absorption, ratio of maximum concentrations, and relative rate of absorption of verapamil and propranolol were revealed. For ethacizine, a statistically significant increase in the time of attaining maximum concentration and volume of distribution and a decrease in the maximum concentration, rate of absorption, ratio of maximum concentrations, and relative rate of absorption under conditions of antiorthostatic hypokinesia were found.

2011-01-01·Kardiologiia4区 · 医学

[Appearance of ECG signs of the Brugada syndrome during therapy with class 1C antiarrhythmic drug ethacizine].

4区 · 医学

Article

作者: Makarov, L M ; Komoliatova, V N

100 项与乙沙西嗪相关的药物交易

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