Phase I, Double-Blind, Placebo-Controlled, Ascending, Single-Dose, Safety, Tolerability and Pharmacokinetic Study of Bisnorcymserine (BNC), a Highly Selective Inhibitor of Butyrylcholinesterase, in Healthy Adult Volunteers

Background:
- Alzheimer s disease (AD) is a brain disease that impairs memory, cognitive abilities and the ability to function independently. It is the most common cause of dementia in older people. It is caused by abnormal proteins in the brain that affect how neurons communicate with each other. Researchers are looking for drugs that can slow down the disease or treat its symptoms. One drug, called bisnorcymserine (BNC), may help improve brain function and symptoms in people with AD. BNC is designed to block a chemical that affects how neurons communicate with each other. Researchers want to see how BNC works in healthy older volunteers.
Objectives:
- To look at how the body processes bisnorcymserine taken by mouth and how safe it is for healthy older volunteers.
Eligibility:
- Healthy volunteers at least 55 years of age.
Design:
* Participants will be screened with a physical exam, medical history, and blood and urine tests.
* Within 3 weeks from the screening visit, participants will come to the National Institute on Aging clinical unit for a 2-night stay. On the morning of the second day, they will take either a BNC capsule or a placebo. They will not know which tablet they are taking.
* Blood samples will be collected frequently throughout the second and third days of the study visit. The last blood sample will be collected about 32 hours after taking the study capsule. Participants will have heart function tests and other exams during the visit. Once the tests are done, they will leave the clinical center.
* Participants will have a final follow-up visit about 1 week after leaving the clinical center.

开始日期2013-01-29

申办/合作机构

National Institute on Aging

100 项与 Bisnorcymserine 相关的临床结果

登录后查看更多信息

100 项与 Bisnorcymserine 相关的转化医学

登录后查看更多信息

100 项与 Bisnorcymserine 相关的专利（医药）

登录后查看更多信息

190

项与 Bisnorcymserine 相关的文献（医药）

2026-01-01·BIORESOURCE TECHNOLOGY

Optimization of bacterial nanocellulose synthesis using surfactants for immobilization of Saccharomyces cerevisiae to enhance resistance to lignocellulose-derived inhibitor

Article

作者: Bai, Yang ; Chen, Linxu ; Wei, Dingkang ; Lin, Jianqiang ; Wu, Guochao ; Xu, Zixiang ; Han, Shuai ; Lin, Jianqun ; Yan, Yiran ; Liu, Jie ; Feng, Yetong ; Chen, Peihong ; Chen, Tao

Optimization of bacterial nanocellulose (BNC) synthesis using surfactants for immobilization of Saccharomyces cerevisiae to enhance resistance to lignocellulose-derived inhibitors is critical for improving bioethanol production efficiency. Lignocellulosic hydrolysates often contain inhibitors such as ferulic acid, which significantly reduce yeast fermentation activity. BNC, with its unique three-dimensional network structure, is a promising carrier for yeast immobilization. However, its dense structure limits yeast cell attachment and nutrient transfer. In this study, rhamnolipids (RHA), an anionic biosurfactant, were introduced into the Hestrin-Schramm (HS) medium. Adding 4 g/L RHA increased the specific surface area of BNC from 26.55 to 37.59 m²/g, the porosity from 45.34 ± 6.65 % to 55.34 ± 2.10 %, the water holding capacity from 179.00 ± 9.03 g/g to 208.19 ± 3.20 g/g and decreased the crystallinity of BNC from 95.04 % to 60.27 %. Under 5 mM ferulic acid, the immobilized yeast exhibited enhanced glucose utilization and began ethanol metabolism earlier. This study presents an environmentally friendly immobilization method and holds significant potential for batch fermentation under inhibitory conditions.

2025-12-01·INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A novel esculin-loaded bacterial nanocellulose wound dressing enhances cutaneous wound healing via modulation of inflammation, oxidative stress, and growth factor expression

Article

作者: Rezaei, Farid ; Hashemnia, Mohammad ; Emaminia, Amir ; Cheraghi, Hadi

Wound healing is a complex biological process involving tightly regulated phases of inflammation, proliferation, and remodeling. Developing multifunctional wound dressings that can actively modulate these processes remains a key challenge in regenerative medicine. Wound healing is a complex biological process involving tightly regulated phases of inflammation, proliferation, and remodeling. Developing multifunctional wound dressings that can actively modulate these processes remains a key challenge in regenerative medicine. The BNC/Esc composite film was thoroughly characterized using SEM, FTIR, XRD, swelling behavior, drug release studies, and in vitro cytocompatibility assays. The in vivo therapeutic efficacy was evaluated in a full-thickness excisional wound model in rats over 21 days using histological, biochemical, and molecular analyses. The BNC/Esc film exhibited a uniform nanofibrous morphology, high swelling capacity and porosity, and sustained biphasic esculin release while maintaining excellent biocompatibility. In vivo, the dressing significantly accelerated wound contraction and re-epithelialization, enhanced collagen deposition and alignment, promoted fibroblast proliferation and angiogenesis via upregulation of bFGF and VEGF, and suppressed inflammation and oxidative stress by reducing IL-1β, MPO, and MDA levels, while increasing GPx and SOD activities. This work introduces an innovative natural compound-loaded BNC platform that integrates mechanical support with molecular-level regulation of inflammation and redox balance, offering a promising, multifunctional biomaterial for advanced wound healing applications.

2025-11-12·ACS materials Au

Tuning Ternary Deep Eutectic Solvent Semiconductivity and Specific Capacitance Properties via Solubilizing Bacterial Nanocellulose for Flexible Soft Material

Article

作者: Kattel, Samir ; Cabo, Maurelio ; LaJeunesse, Dennis

Bacterial nanocellulose (BNC) shows promise in sustainable materials science, but its insolubility limits broader applications. This study introduces a ternary deep eutectic solvent (TDES) composed of Choline Chloride, Imidazole, and Tannic acid to effectively dissolve BNC. The resulting solution exhibits enhanced bandgap energy, increasing from 4.348 to 4.528 eV (direct) and 4.156 to 4.471 eV (indirect), highlighting its potential application in a wide-bandgap semiconductor. Cyclic voltammetry revealed improved specific capacitance, indicating enhanced energy storage capacity. Its application in flexible soft material underscores its viability as a highly insulating yet sufficiently conductive material for future studies in biosensors, optoelectronics, and solar cells. By overcoming BNC's solubility challenges while enhancing TDES properties, this study advances biobased electronics and optical applications, paving the way for eco-friendly technological innovations.

100 项与 Bisnorcymserine 相关的药物交易

登录后查看更多信息