PCDC(PCDC) - 药物靶点：CDCP1_专利_临床

概要

基本信息

药物类型

单克隆抗体

别名-

靶点

CDCP1

作用方式

抑制剂

作用机制

CDCP1 inhibitors(CUB domain containing protein 1 inhibitors)

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Chiome Bioscience, Inc.

在研机构-

非在研机构

Chiome Bioscience, Inc.

权益机构-

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 PCDC 相关的临床结果

登录后查看更多信息

100 项与 PCDC 相关的转化医学

登录后查看更多信息

100 项与 PCDC 相关的专利（医药）

登录后查看更多信息

11

项与 PCDC 相关的文献（医药）

2026-01-01·JCO Clinical Cancer Informatics

Novel Electronic Health Record–Based Data Commons for Pancreatic Cancer

Article

作者: Shiefelbein, Andrea ; Zafar, Syed Nabeel ; Weber, Sharon ; McMahan, Gabriel ; LoConte, Noelle K. ; Ahmed, Kaleem S. ; Issaka, Sheriff M. ; Ali, Muhammad Maisam ; Churpek, Matthew M. ; Callaci, Thomas ; Marcinak, Clayton T. ; Yan, Yonghe ; Mathew, Jomol ; Afshar, Majid

PURPOSE:

Clinical research in pancreatic cancer (PC) has been limited because of a lack of granular data in national data sets. An electronic health record (EHR)–based data set specifically designed for PC has immense potential to advance research. This study describes the creation of an EHR-based data commons for patients with PC.

METHODS:

We generated an index cohort of adult patients at our institution diagnosed with PC (International Classification of Diseases for Oncology, codes C25.0-25.9) between January 1, 2010, and December 31, 2023. To develop the Pancreatic Cancer Data Commons (PCDC), we linked six data sources: (1) institutional EHR data, (2) cancer-specific data from the North American Association of Central Cancer Registries, (3) surgical outcomes from the National Surgical Quality Improvement Program, (4) community-level data from the American Community Survey, (5) national mortality data from Obituary.com, and (6) genomic data from the cBioPortal for Cancer Genomics. We evaluated the feasibility of using the Observational Medical Outcomes Partnership common data model. The data set is stored on a cloud-based, Health Insurance Portability and Accountability Act–secure, and National Institute of Standards and Technology–compliant server.

RESULTS:

The PCDC currently includes data of 3,542 unique patients. The mean age at diagnosis is 66.6 ± 11.7 years; 53.3% is male, and 92.2% is White. Linkage to six national data sets increased the completeness of cancer-specific data from 31.3% to 71.6%. Most patients presented at stage IV (43.6%), followed by stage I (22.6%). As of the latest update, 1,074 (30.3%) patients were still alive.

CONCLUSION:

The PCDC is a centralized resource that solves a gap in PC research. The ability to securely link and analyze protected patient data is a strategic step toward enhancing clinical research and optimizing care for patients with PC. Our future work includes expanding the PCDC to multiple centers using common data models.

2024-09-01·Journal of Medical Imaging and Radiation Sciences

Enablers and barriers to delivering person centred dementia care: Perceptions and experiences of diagnostic and therapeutic radiography practitioners

Article

作者: Higgins, Robert ; Innes, Anthea ; Spacey, Adam

INTRODUCTION:

There is a lack of evidence about the experiences of radiographers providing care to people living with dementia (PLWD). This study explored the perceptions and experiences of radiography practitioners when delivering person-centred dementia care (PCDC) in both diagnostic imaging and radiotherapy departments.

METHODS:

A two-phase qualitative multi-method study was conducted. For phase 1, fifteen diagnostic and two therapeutic radiography practitioners from across the UK participated with online focus group discussions. For phase 2, four key stakeholders involved with the development of the UK Society of College of Radiographers Caring for People with Dementia practice guidelines for diagnostic and therapeutic radiography practitioners took part with individual semi-structured interviews.

RESULTS:

Participants from both phases identified enablers and barriers to providing person-centred care to individuals living with dementia. Three themes were identified that were linked to (1) Time and workload pressures in delivering person-centred dementia care, (2) Workplace practice and norms, and (3) Areas for improvement in delivering person-centred dementia care.

DISCUSSION:

Delivering PCDC can be challenging in practice. This is often due to workplace cultures where time and resources linked to productivity and waiting lists are the norms and impact on the delivery of PCDC. Leaders and managers of departments were thought to not always value a culture of PCDC but were seen as key influencers in supporting change and impact in delivering PCDC. Radiography practitioners were not always aware that a patient had dementia prior to their attendance in the department making it difficult to prepare ahead of appointments. Care partners were identified as having the potential to help alleviate some challenges radiographers faced. Findings also suggest a need for more education and training linked to dementia awareness. Further research is warranted in this area.

2018-01-01·Journal of cutaneous and aesthetic surgery

Injection lipolysis: A systematic review of literature and our experience with a combination of phosphatidylcholine and deoxycholate over a period of 14 years in 1269 patients of Indian and South East Asian origin

Article

作者: Borole, Ateesh J ; Thomas, Mohan K ; D'Silva, James A

BACKGROUND:

Phosphatidylcholine and deoxycholate (PC-DC) injections have been used as nonsurgical alternatives to liposuction. DC as a constituent for lipolysis has recently been approved by the US Food and Drug Administration.

AIM:

PC and DC have independently been used in lipolysis. We hereby present a systematic review of literature on injection lipolysis and share our experience of using DC in combination with PC for injection lipolysis. We have retrospectively evaluated the effects of PC-DC treatments in varied age groups, both sexes, and over different target areas.

MATERIALS AND METHODS:

This study spans over 14 years wherein 1269 patients of different age groups and sex were treated with injection lipolysis with PC-DC combination. The PC-DC cocktail injection was given to all patients for an average four sessions every 4 weeks, and the results were assessed after 8 weeks from the last session.

RESULTS:

The effects were best appreciated over the face (malar, jawline, and submental areas) and upper arm, whereas average effect was observed on the thighs and around the knees. We have also used lipolysis as a primary modality as well as a touch-up modality following liposuction. The results are better appreciated in primary lipolysis. The need for follow-up sessions (1-2 sessions) of lipolysis and the quantification of results in subsequent sessions reveal that maximal improvement is achieved in the first session.

CONCLUSION:

PC-DC cocktail used for lipolysis as a local administration is effective for reducing unwanted fat. It shows great efficacy in treating localized fat, especially over the face and bra roll in the women of younger age group (20-30 years).

100 项与 PCDC 相关的药物交易

登录后查看更多信息