Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center)(Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center))

概要

基本信息

药物类型

治疗性疫苗、mRNA疫苗

别名-

靶点-

作用机制

免疫刺激剂

治疗领域

内分泌与代谢疾病

在研适应症-

非在研适应症

2型糖尿病

原研机构

Mount Sinai Medical Center of Florida, Inc.

在研机构-

非在研机构

Mount Sinai Medical Center of Florida, Inc.

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center) 相关的临床结果

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100 项与 Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center) 相关的转化医学

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100 项与 Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center) 相关的专利（医药）

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1

项与 Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center) 相关的文献（医药）

1982-09-01·Infection and Immunity2区 · 医学

Type-specific protection of neonatal rats from lethal group B streptococcal infection by immune sera obtained from human volunteers vaccinated with type III-specific polysaccharide

2区 · 医学

Article

作者: Shockman, G D ; McIntosh, T S ; De Cueninck, B J ; Eisenstein, T K ; Swenson, R M

Sera obtained from human volunteers at 6 weeks after vaccination with highly purified type III polysaccharide antigen prepared from a group B Streptococcus, strain M732, were found to protect neonatal rats from otherwise lethal infection by the homologous strain. The specific antibody content of the sera, expressed in micrograms of antibody protein per milliliter, was determined by an enzyme-linked immunosorbent assay in conjunction with quantitative precipitin analysis. For two sera studied in detail, the protective dose of antibody for 50% of the animals was 0.4 micrograms. Immune serum obtained from a volunteer who received type II polysaccharide vaccine was not protective against type III infection. Absorption of anti-type III serum by quantitative precipitation of antibodies with type III polysaccharide completely removed the passive protective activity of the serum. The results show that antibodies induced in humans by purified type II polysaccharide give serotype-specific protection in an animal model of neonatal infection.

100 项与 Type II diabetes dendritic cell vaccine (Mount Sinai Medical Center) 相关的药物交易

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