釣藤散(Diao Teng San) - 在研适应症：头痛，高血压_专利_临床

概要

基本信息

药物类型

中药

别名

钓藤散

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病心血管疾病

在研适应症

头痛高血压

非在研适应症-

原研机构

Matsuura Yakugyo Co. Ltd.

在研机构

Matsuura Yakugyo Co. Ltd.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

日本 (1986-10-01),

头痛高血压

最高研发阶段(中国)-

特殊审评-

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关联

100 项与釣藤散相关的临床结果

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100 项与釣藤散相关的转化医学

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100 项与釣藤散相关的专利（医药）

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1

项与釣藤散相关的文献（医药）

2003-01-01·The American Journal of Chinese Medicine2区 · 医学

Choto-san Prevents Occurrence of Stroke and Prolongs Life Span in Stroke-Prone Spontaneously Hypertensive Rats

2区 · 医学

Article

作者: Sekiya, Nobuyasu ; Goto, Hirozo ; Shimada, Yutaka ; Terasawa, Katsutoshi ; Kasahara, Yuji ; Yokoyama, Koichi ; Yang, Qiao ; Hikiami, Hiroaki

The effects of long-term oral administration of Choto-san (Diao-Teng-San in Chinese) extract on the occurrence of stroke and life span were investigated in stroke-prone spontaneously hypertensive rats (SHR-SPs). Twenty-four rats were ramdomized into three groups. From 8 weeks of age, 0.1% and 0.3% Choto-san groups were given water containing 0.1% (150 mg/kg/day) and 0.3% (450 mg/kg/day) Choto-san extract, respectively. A control group was given only water. The mean survival times of the control group, 0.1% and 0.3% Choto-san groups were 122.1, 159.8 and 176.8 days, respectively. The percent survivals of both the 0.1% and 0.3% Choto-san groups were significantly enhanced compared to the control (Kaplan-Meier analysis followed by log-rank test; 0.1% Choto-san: p < 0.05; 0.3% Choto-san: p < 0.05). Furthermore, the cumulative percent occurrence of neurological and behavioral signs accompanying stroke in the 0.3% Choto-san group was significantly inhibited compared to the control (p < 0.05). These results suggested that Choto-san prevents the occurrence of stroke and prolongs the life span of SHR-SPs.

100 项与釣藤散相关的药物交易

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