GAL-475(GAL-475) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用机制-

治疗领域

神经系统疾病呼吸系统疾病

在研适应症-

非在研适应症

睡眠呼吸暂停综合征

原研机构

Neurim Pharmaceuticals Ltd.

在研机构-

非在研机构

Galleon Pharmaceuticals, Inc.

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

1

项与 GAL-475 相关的临床试验

NL-OMON55229 / CompletedN/A

A Phase 1, Randomized, Placebo-Controlled, Double-Blind, First in Man, Single Escalating Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GAL-475 in Healthy Male Volunteers and Male Subjects with Sleep Apnea - CS0352-200069

开始日期2021-01-27

申办/合作机构

Neurim Pharmaceuticals Ltd.

100 项与 GAL-475 相关的临床结果

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100 项与 GAL-475 相关的转化医学

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100 项与 GAL-475 相关的专利（医药）

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1

项与 GAL-475 相关的文献（医药）

2015-01-01·Advances in Experimental Medicine and Biology4区 · 医学

GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells

4区 · 医学

Article

作者: Mark L. Dallas ; Chris Peers ; Francis J. Golder ; D. Euan MacIntyre ; Ryan Gruber ; Santhosh Baby

GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the site and mechanism of action of GAL-021 and GAL-160 we utilized spirometry in urethane anesthetized rats subjected to acute bilateral carotid sinus nerve transection (CSNTX) or sham surgery. In addition, using patch clamp electrophysiology we evaluated ionic currents in carotid body glomus cells isolated from neonatal rats. Acute CSNTX markedly attenuated and in some instances abolished the ventilatory stimulant effects of GAL-021 and GAL-160 (0.3 mg/kg IV), suggesting the carotid body is a/the major locus of action. Electrophysiology studies, in isolated Type I cells, established that GAL-021 (30 μM) and GAL-160 (30 μM) inhibited the BK(Ca) current without affecting the delayed rectifier K(+), leak K(+) or inward Ca(2+) currents. At a higher concentration of GAL-160 (100 μM), inhibition of the delayed rectifier K(+) current and leak K(+) current were observed. These data are consistent with the concept that GAL-021 and GAL-160 influence breathing control by acting as peripheral chemoreceptor modulators predominantly by inhibiting BK(Ca) mediated currents in glomus cells of the carotid body.

100 项与 GAL-475 相关的药物交易

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