The effect of proxocarpine upon the state of the anterior eye chamber, pupil size, intraocular pressure (IOP), and ophthalmic hydrodynamics was examined in 32 chinchilla rabbits.The properties of proxocarpine were compared to those of the initial monopreparations, and the safety of the new eyedrops was evaluated.The proxocarpine eyedrops were well tolerated by the rabbit eyes, produced a pronounced miotic action, and reduced intraocular pressure (IOP) over a 24 h period by reliably increasing the drainage coefficientA comparative study of the hypotensive effects of proxodolol, pilocarpine, and proxocarpine revealed the advantages of the latter combined form.Proxocarpine showed a more pronounced and longer hypotensive effect as compared to that of each component used sep.The IOP decrease induced by proxocarpine was more physiol., being due to an increase in the drainage coefficientThe miotic effect of proxocarpine was somewhat lower as compared to that of plain pilocarpine.