Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology)(Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology))

概要

基本信息

药物类型

间充质干细胞疗法

别名

AD-MSC(Vinmec Research Institute of Stem Cell and Gene Technology)

靶点-

作用机制

干细胞替代物

治疗领域

泌尿生殖系统疾病其他疾病

在研适应症

女性性功能障碍性功能障碍

非在研适应症-

原研机构

Vinmec Research Institute of Stem Cell and Gene Technology

在研机构

Vinmec Research Institute of Stem Cell and Gene Technology

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的临床试验

NCT05329662 / Recruiting临床2期IIT

Evaluation of Autologous Adipose Tissue-derived Mesenchymal Stem Cell Efficacy for the Treatment of Sexual Function Impairment in Female

Hormones are a chemical substance synthesized and secreted by endocrine gland. Several vital hormones, including Mullerian hormone (AMH), follicle-stimulating hormone (FSH), and Estradiol (E2), play crucial roles in regulating female sexual function.- Hormone therapy is used to treat female hormone deficiency and results in a significant improvement, but long-term use increases cardiovascular disease or cancer risk. Other treatments do not give apparent results. Therefore, it is necessary to develop new and effective treatments to achieve the requirements of improving health in general and sexual health in particularly in women. AD-MSCs have been widely used as autologous and allogeneic stem cell sources to treat numerous disease recently, and they have been proven to be safe. The phase I trial showed that administration of autologous AD-MSCs at the dose of 1.0 x 10^6 cells/kg patient bodyweight was safe for patients with sex hormone deficiency. The therapy introduced potential improvement in sexual and general quality of life indicating by the increased FSFI. Therefore, this phase II trial to evaluate efficiency of autologous adipose tissue-derived mesenchymal stem cells therapy in treatment of female patients with sexual function impairment.

开始日期2023-05-01

申办/合作机构

Vinmec Research Institute of Stem Cell and Gene Technology

EUCTR2020-001266-11-ES / Not yet recruiting临床2期

Two-center, randomized, controlled clinical trial with two treatment arms to evaluate the safety and efficacy of intravenous administration of expanded allogeneic adipose tissue adult mesenchymal cells in critically ill patients COVID-19.

开始日期2020-04-16

申办/合作机构-

RBR-2fr526n / CompletedN/AIIT

Effects of cell therapy with mesenchymal stem cells from adipose tissue and platelet-rich plasma in the treatment of osteoartrite that was not responsive to drug treatment

开始日期2018-06-29

申办/合作机构

Universidade Federal de Mato Grosso do Sul

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100 项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的临床结果

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100 项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的转化医学

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100 项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的专利（医药）

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41

项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的文献（医药）

2024-08-16·Stem Cells Translational Medicine

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy

Article

作者: Lee, Pei-Ru ; Shiau, Ai-Li ; Wu, Pensee ; Chang, Chao-Ching ; Chen, Yi-Cheng ; Yang, Mei-Lin ; Hu, Che-Yuan ; Chen, Pi-Che ; Shieh, Gia-Shing ; Lee, Ya-Che ; Wu, Chao-Liang ; Su, Bing-Hua

AbstractOncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can be used as cellular vehicles for delivering oncolytic adenoviruses to tumor sites. Since telomerase activity is found in ~90% of human carcinomas, but undetected in normal adult cells, the human telomerase reverse transcriptase gene (TERT) promoter can be exploited for regulating the replication of oncolytic adenoviruses. Here, we evaluated the antitumor effects of syngeneic murine MSCs loaded with the luciferase-expressing, telomerase-dependent oncolytic adenovirus Ad.GS2 (MSC-Ad.GS2) and Ad.GS2 alone on metastatic MBT-2 bladder tumors. MSCs supported a low degree of Ad.GS2 replication, which could be augmented by coculture with MBT-2 cells or tumor-conditioned medium (TCM), suggesting that viral replication is increased when MSC-Ad.GS2 migrates to tumor sites. MBT-2 cells and TCM enhanced viral replication in Ad.GS2-infected MSCs. SDF-1 is a stem cell homing factor. Our results suggest that the SDF-1/STAT3/TERT signaling axis in MSCs in response to the tumor microenvironment may contribute to the enhanced replication of Ad.GS2 carried by MSCs. Notably, we demonstrate the potent therapeutic efficacy of systemically delivered MSC-Ad.GS2 in pleural disseminated tumor and experimental metastasis models using intrapleural and tail vein injection of MBT-2 cells, respectively. Treatment with MSC-Ad.GS2 significantly reduced tumor growth and prolonged the survival of mice bearing metastatic bladder tumors. Since telomerase is expressed in a broad spectrum of cancers, this therapeutic strategy may be broadly applicable.

2024-02-01·Journal of Wound Care

Polyurethane foam dressing with non-adherent membrane improves negative pressure wound therapy in pigs

Article

作者: Yang, JunTao ; Yang, Feng ; Zuo, Jun ; Zhu, Yi ; Yang, Yong ; Huang, Ze Lin ; Cheng, Biao

Objective: Negative pressure wound therapy (NPWT) is considered to be an effective technique to promote the healing of various wounds. The aim of this study was to evaluate different wound dressings combined with NPWT in treating wounds in Wuzhishan pigs. Method: Excisions were made in the backs of the pigs and were covered with polyvinyl alcohol (PVA) dressing, polyurethane (PU) dressing or PU dressing with non-adherent membrane (PU-non-ad). NPWT was applied to the wound site. In the control group, basic occlusive dressing (gauze) without NPWT was applied. On days 0, 3, 7, 14, 21 and 28 post-surgery, the wound size was measured during dressing change, and wound healing rate (WHR) was calculated. In addition, blood perfusion within 2cm of the surrounding wound was measured by laser doppler flowmetry. Dressing specimen was collected and microbiology was analysed. Granulation tissues from the central part of the wounds were analysed for histology, vascular endothelial growth factor (VEGF) and cluster of differentiation 31 (CD31) mRNA expression. Results: The PU-non-ad-NPWT significantly (p<0.01) accelerated wound healing in the pigs. Further pathological analysis revealed that the non-adherent membrane effectively protected granulation tissue formation in PU-NPWT treated wounds. The blood perfusion analysis suggested that the non-adherent membrane improved the blood supply to the wound area. Microbiological analysis showed that non-adherent membrane decreased the bacterial load in the PU-NPWT dressing. VEGF and CD31 mRNA expression was upregulated in the wound tissue from the PU-non-ad-NPWT treated groups. Conclusion: In this study, the PU dressing with non-adherent membrane was an ideal dressing in NPWT-assisted wound healing.

2024-02-01·Colloids and Surfaces B: Biointerfaces

Hippocampal-derived extracellular vesicle synergistically deliver active adenosine hippocampus targeting to promote cognitive recovery after stroke

Article

作者: Li, Ziqing ; Ge, Jian ; Xia, Kunwen ; Xu, Haoming ; Zhang, Dandan ; Chen, Zhendong ; Guo, Yiyan ; Liu, Li ; Li, Chu-Hua ; Zhang, Yiquan ; Bai, Weiwei ; Liu, Qingpeng ; Guan, Yan-Qing ; Zhang, Ling-Kun

Ischemic stroke is a neurological disease that leads to brain damage and severe cognitive impairment. In this study, extracellular vesicles(Ev) derived from mouse hippocampal cells (HT22) were used as carriers, and adenosine (Ad) was encapsulated to construct Ev-Ad to target the damaged hippocampus. The results showed that, Ev-Ad had significant antioxidant effect and inhibited apoptosis. In vivo, Ev-Ad reduced cell death and reversed inflammation in hippocampus of ischemic mice, and improved long-term memory and learning impairment by regulating the expression of the A1 receptor and the A2A receptor in the CA1 region. Thus, the developmental approach based on natural carriers that encapsulating Ad not only successfully restored nerves after ischemic stroke, but also improved cognitive impairment in the later stage of ischemic stroke convalescence. The development and design of therapeutic drugs provides a new concept and method for the treatment of cognitive impairment in the convalescent phase after ischemic stroke.

100 项与 Adipose Tissue-derived Mesenchymal Stem Cell(Vinmec Research Institute of Stem Cell and Gene Technology) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
女性性功能障碍	临床2期	越南	Vinmec Research Institute of Stem Cell and Gene Technology	2023-05-01
性功能障碍	临床2期	越南	Vinmec Research Institute of Stem Cell and Gene Technology	2023-05-01