聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products)(Pegylated recombinant human interleukin-6(Chengdu Institute of Biological Products))

概要

基本信息

药物类型

白细胞介素

别名-

靶点

IL-6RA

作用方式

激动剂

作用机制

IL-6R激动剂(白细胞介素-6受体α亚基激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

成都生物制品研究所有限责任公司

在研机构-

非在研机构

成都生物制品研究所有限责任公司

权益机构-

最高研发阶段无进展临床申请

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

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关联

100 项与聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products) 相关的临床结果

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100 项与聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products) 相关的转化医学

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100 项与聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products) 相关的专利（医药）

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1

项与聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products) 相关的文献（医药）

2009-01-01·Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Pharmacokinetics of PEG recombinant human interleukin-6 in rats].

Article

作者: Yang, Guang ; Yin, Hai-Lin ; He, Xue-Ling ; Zhang, Xue-Me

OBJECTIVE:

To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.

METHODS:

Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.

RESULTS:

PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.

CONCLUSION:

The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG.

100 项与聚乙二醇化重组人白介素-6(Chengdu Institute of Biological Products) 相关的药物交易

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