OBJECTIVE:To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.
METHODS:Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.
RESULTS:PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.
CONCLUSION:The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG.