Octreotide (Imagine Pharma)

Pressure-sensitive paints (PSP) enable non-intrusive visualization of surface pressure distribution on model surface which is important for aerodynamic studies. However, conventional PSP materials suffer from photobleaching and inadequate sensitivity. In this work, we rationally designed and synthesized novel dendritic oxygen probes (PT1 and PT2) by covalently grafting fluorinated dendrons onto platinum tetrakis(pentafluorophenyl)porphyrin (PT0) (a common oxygen probe). Subsequently, PT2 loaded nanofibers membranes from polycaprolactone (PCL) were fabricated by electrospinning. Fabricated membranes showed high oxygen sensitivity (I₀/I₁₀₀ = 35.3) with excellent flexibility, good reversibility, and outstanding photostability (merely 2.0% intensity loss after prolonged irradiation). The pressure sensitivity was found around 0.73 % per kilopascal. Furthermore, significant variation in emission intensity with respect to the variation in air pressure (1.3-101.32 kPa), facilitates the naked eye visualization of the pressure distribution on the membrane surface. Such excellent oxygen and pressure sensitivity and photostability might be due to high fluorine contents of complex dendritic structure of PT2. This flexible fluorine-functionalized dendritic oxygen probe puts forward a facile and effective strategy to develop advanced PSP materials enabling accurate pressure mapping for aerodynamic studies.

The difference in chemical composition between denture base resin and denture teeth requires the development of bonding protocols that increase the union between the materials.

The purpose of this in vitro study was to evaluate the impact of different bonding protocols on the bond between heat-polymerized and 3-dimensionally (3D) printed acrylic resin denture bases and acrylic resin prefabricated and 3D printed artificial teeth.

Four types of artificial teeth were evaluated: prefabricated acrylic resin (VITA MFT) and 3D printed (Cosmos TEMP, PRIZMA 3D Bio Denture, and PrintaX AA Temp) bonded to 20×24-mm cylinders of heat-polymerized (VipiWave) and 3D printed (Cosmos Denture, PRIZMA 3D Bio Denture, and PrintaX BB Base) denture bases. Three bonding protocols were tested (n=20): mechanical retention with perforation + monomer (PT1), mechanical retention with perforation + airborne-particle abrasion with 50-µm aluminum oxide + monomer (PT2), and mechanical retention with perforation + Palabond (PT3). Half of the specimens in each group received 10 000 thermocycles and were then subjected to the bonding test at a crosshead speed of 1 mm/minute. The failure type was analyzed and scanning electron micrographs made. Additionally, surface roughness (Ra) and wettability (degree) were analyzed (n=15). ANOVA was used to evaluate the effect of the bonding protocol, and the Student t test was applied to compare the experimental groups with the control (α=.05). For type of failure, a descriptive analysis was carried out using absolute and relative frequency. The Kruskal-Wallis test was used to evaluate the surface changes (α=.05).

Among the protocols, PT3 with in Yller and PT2 with Prizma had the highest bond strengths of the heat-polymerized denture base and 3D printed teeth (P<.05). When comparing the experimental groups with the control, PT3 and PT2 had greater union with the 3D printed denture base + 3D printed teeth (in Yller), with no difference from the heat-polymerized denture base + prefabricated teeth in acrylic resin. The treatment of the 3D printed tooth surfaces affected the surface roughness of Prizma (P<.001) and wettability (P<.001).

To increase the bond between Yller 3D printed denture base + 3D printed teeth, a bonding protocol including mechanical retention with perforation + Palabond or mechanical retention with perforation + airborne-particle abrasion with aluminum oxide + monomer is indicated. For the other materials tested, further bonding protocols need to be investigated.