Phase II clinical study for efficacy and safety of interferon gamma combined with docetaxel, carboplatin and trastuzumab in neoadjuvant treatment of HER-2 positive breast cancer

开始日期2019-08-01

申办/合作机构

河北医科大学第四医院

ISRCTN72024361

/ CompletedN/AIIT

Randomised controlled trial of short course adjunctive interferon gamma for inital treatment of human immunodeficiency virus (HIV)-associated cryptococcal meningitis: effect on rate of clearance of infection and immune response

开始日期2007-07-10

申办/合作机构

St. George's University of London

100 项与 Interferon gamma (Nostrum) 相关的临床结果

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100 项与 Interferon gamma (Nostrum) 相关的转化医学

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100 项与 Interferon gamma (Nostrum) 相关的专利（医药）

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项与 Interferon gamma (Nostrum) 相关的文献（医药）

1990-04-01·Gynecologic Oncology2区 · 医学

Interferon γ treatment for cervical intraepithelial neoplasia

2区 · 医学

Article

作者: Toru Hachisuga ; Yoshinobu Hayashi ; Hajime Sugimori ; Masatoshi Yokoyama ; Tsuyoshi Iwasaka

Eight patients with cervical intraepithelial neoplasia (CIN) were administered perilesional injections of human recombinant interferon gamma (IFN-gamma), and the response was evaluated by colposcopy and exfoliative cytology and then by histopathology. In all patients, colposcopic and cytologic findings improved after two to four injections of IFN-gamma and the cytologic findings reverted to normal in five of these eight patients. All five were free of dysplastic lesions. The other three patients with positive cytology and positive colposcopy after completion of IFN-gamma treatment underwent hysterectomy or laser conization, and histopathologic examination revealed residual dysplastic lesions. On the other hand, a control study revealed that only one of eight patients showed spontaneous regression during the 3-month observation period. During the course of these treatments, keratinizing cells were often present in the cervical smears and isolated cell keratinization was often evident in the residual dysplastic lesions of the surgical specimens. These observations suggest that IFN-gamma treatment is an effective therapeutic method for CIN lesions and that IFN-gamma has the potential to differentiate nonkeratinizing squamous cells into keratinizing cells.

100 项与 Interferon gamma (Nostrum) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
慢性阻塞性肺疾病	临床2期	-	Stony Brook University School of Medicine	-
慢性阻塞性肺疾病	临床2期	-	Nostrum	-
肺纤维化	临床2期	-	Nostrum	-
肺纤维化	临床2期	-	Stony Brook University School of Medicine	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2017	N/A	非小细胞肺癌 \| 黑色素瘤	-	Interferon-gamma (INFG) (High INFG expression)	(鹽簾網齋廠淵夢艱簾鹹) = 遞鑰齋鬱製蓋齋壓製憲範艱範鬱鹹淵積鑰網憲 (廠觸餘衊衊選製齋鹹顧 ) 更多	积极	2017-05-30
				Interferon-gamma (INFG) (Low INFG expression)	(鹽簾網齋廠淵夢艱簾鹹) = 鹹獵顧餘網鹹齋願遞選範艱範鬱鹹淵積鑰網憲 (廠觸餘衊衊選製齋鹹顧 ) 更多