更新于：2024-11-21

Danggui Tongjing Granules

当归痛经颗粒

更新于：2024-11-21

概要

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症-

非在研适应症

原发性痛经

原研机构-

在研机构-

非在研机构

山西省中医药研究院（山西省中医院）北京凯晋科技有限公司

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)无进展

特殊审评-

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关联

项与当归痛经颗粒相关的临床试验

CTR20131781 / Completed临床2期

当归痛经颗粒治疗原发性痛经气滞血瘀证的有效性与安全性的分层区组随机双盲安慰剂对照多中心临床试验

评价当归痛经颗粒治疗原发性痛经（气滞血瘀证）的安全性、有效性

开始日期2012-05-04

申办/合作机构

山西省中医药研究院（山西省中医院）

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100 项与当归痛经颗粒相关的临床结果

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100 项与当归痛经颗粒相关的转化医学

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100 项与当归痛经颗粒相关的专利（医药）

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项与当归痛经颗粒相关的文献（医药）

2023-11-24·Medicine

Effect of TCM rehabilitation program on activities of daily living in patients with post-stroke limb spasticity: An observational study

Article

作者: Cong, Deyu ; Wang, Yufeng ; Qiu, Long ; Yang, Chong ; Zhu, Chuanxi ; Sun, Weichen ; Ji, Guangcheng

Background:Stroke is a neurological disease with many common complications that reduce the activities of daily living and the quality of life of patients. Traditional Chinese medicine (TCM) rehabilitation techniques, scalp acupuncture, and TCM can relieve spasticity symptoms and recovery from physical obstacles is significant.Methods:Three hundred twenty-one patients with post-stroke limb spasticity were randomly divided into trial and control groups, with 159 and 162 patients in the trial and control groups, respectively. The control group received basic treatment combined with modern rehabilitation techniques, whereas the trial group received basic treatment combined with TCM, Tuina, and scalp acupuncture with kinesiotherapy. The treatment course in both groups was 4 weeks. The Modified Ashworth Scale, magnetic resonance imaging, and Stroke Specific Quality of Life Scale were used to evaluate limb spasticity, activities of daily living, and quality of life, respectively. PASW 18.0 was used for statistical analysis.Results:With a longer treatment period, the improvement in limb spasticity was greater in the trial group than in the control group (P < .05). Similarly, improvements in activities of daily living and quality of life were better in the trial group than in the control group (P < .05).Conclusion:The TCM rehabilitation program using Tongjing Tiaoxing combined with scalp acupuncture and kinesiotherapy can effectively treat spasticity symptoms in stroke patients and improve their activities of daily living and quality of life.

2001-06-01·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Comparative clinical study on treatment of varicocele caused infertility by tongling granule and surgical operation].

Article

作者: Kan, Q L ; Lu, J K ; Qi, G C

OBJECTIVETo observe the effect of Tongjing granule (TJG) in treating varicocele caused infertility.METHODSComparative observation was carried on 75 cases of male infertility caused by moderate or severe varicocele with abnormal semen, they were divided into two groups: the 44 patients in the TCM group treated with TJG and the 31 patients in the operation group treated by surgical operation (high ligation of spermatic vein and/or inferior epigastric venous bypass). All patients were followed up periodically to observe the amount, survival rate and activity of sperm by computerized automatic seminal analyser (CASA), as well as the occurrence of pregnancy in their partner.RESULTSNo significant difference was found in various parameters between the two groups. After treatment, the improvement of seminal density, amount of active sperms and forward moving sperms were lower in the TCM group than that in the operation group, but according to CASA, the improvement of TCM group is better than that of operation group. There was insignificance in the operation group between pre- and post-treatment, P > 0.05.CONCLUSIONTJG could treat the varicocele caused infertility with the clinical effect similar to the surgical operation, and was superior in improving motility of sperm. It indicates that surgical operation could only improve the local lesion, but TJG could modulate the general condition of patients also.

Metabolic Brain Disease

Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach

Article

作者: Meng, Huihui ; Zheng, Qi ; Wang, Junsong ; Yao, Benxing ; Xu, Di ; Wang, Qing ; Xiao, Ran ; Liu, Wenya ; Xu, Qian ; Hu, Ziyun ; Liu, Lin ; Hu, Yudie

Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine (TCM) including the herb pair of Zhiqiao-Danggui (ZD) offers a multifaceted treatment approach through promoting blood circulation, yet its specific anti-ischemic mechanism remains unclear. This study used the photochemically induced thrombosis (PIT) mouse model and the oxygen glucose deprivation/reoxygenation (OGD/R) cell model to explore the therapeutic effect of ZD on ischemic stroke. Mice were treated with high and low doses of ZD extract or positive control. Behavior was assessed using the grid test. The brain tissue was then subjected to infarct volume assessment, histopathology, oxidative stress marker detection, LC/MS metabolomic analysis and qRT-PCR validation. The therapeutic effect of ZD-medicated serum on OGD/R model was tested on cells. Experimental results show that ZD can improve motor function, reduce infarct size, neuronal damage and apoptosis as well as alleviate oxidative stress in mice. ZD-medicated serum promotes endothelial cell proliferation, improves cell survival against OGD/R-induced injury, reduces oxidative damage and protects mitochondrial function. Metabolomics reveals ZD regulation of metabolites in energy metabolism, amino acid metabolism, TCA cycle, and angiogenesis signaling pathways. qRT-PCR results also showed that ZD could attenuate abnormal conduction of angiogenic signals and enhance vessel stability. This study confirmed the neuroprotective and vasoprotective effects of ZD, highlighted its potential in treating ischemic stroke, and provided a scientific basis for the traditional use of ZD.

100 项与当归痛经颗粒相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
原发性痛经	临床2期	中国	山西省中医药研究院（山西省中医院）	2012-05-04
原发性痛经	临床2期	中国	北京凯晋科技有限公司	2012-05-04