Identification and characterization of a potential ischemia-selective N-methyl-d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788
4区 · 医学
Article
作者: Padmanabhan, S. ; Moore, D. ; Perlman, M. E. ; Zhou, D. ; Zhang, L. ; McBurney, R. N. ; Durant, G. J. ; Fischer, J. B.
The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, (R)-(+)-N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788), is described.