A review on nitric oxide-releasing topical medication as a potential treatment option for atopic dermatitis through antimicrobial and anti-inflammatory activity.It focus on the effect of SB414 on Staphylococcus aureus colonization in atopic dermatitis and the subsequent cutaneous immune response is also observedChanges in expression of key AD-related biomarkers identified by RNA sequencing data were validated using quant. RT-PCR anal. of immune response genes.It discuss the short-term immunomodulatory effects of SB414 on AD lesions, topical nitric oxide-releasing SB414 2% showed significant reductions in Th2,Th22, Th1, and Th17 related biomarker.