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项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的临床试验 / Unknown status早期临床1期IIT An Open, Dose-escalation Clinical Study of Chimeric Exosomal Tumor Vaccines for Recurrent or Metastatic Bladder Cancer
1. Based on the applicant's previous work and combined with the clinical medical resources of our unit, tumor cells were isolated from the lesion site of cancer patients, dendritic cells or macrophages were isolated from peripheral blood, and personalized chimeric exosome vaccine was prepared for patients.
2. To evaluate the safety and tolerability of multiple administration of chimeric exosome vaccine in subjects with hatching or metastatic bladder cancer, explore the maximum tolerated dose (MDT) and dose-limiting toxicity (DLT) in humans, and recommend the safe dose range for the subsequent extended trials and subsequent clinical studies of this product.
3. To reveal the "double-effect" improvement mechanism of chimeric exosome vaccine on the activation of immune response and the microenvironment of bladder cancer lesions, improve the anti-recurrence treatment effect of bladder cancer, and realize the clinical transformation of "double-target and double-effect" chimeric exosome vaccine in the field of individualized precision treatment of bladder cancer patients.
4. To explore the clinical application value of this tumor therapeutic vaccine by using the T-cell receptor immunoomics and immunomolecular evaluation technology platform established by previous researchers, and to provide preliminary clinical research results for further vaccine development.
100 项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的临床结果
100 项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的转化医学
100 项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的专利(医药)
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项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的文献(医药)2020-11-01·Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz4区 · 医学
Kombinationstherapien in der Immunonkologie: Differenzierte regulatorische Herangehensweisen
4区 · 医学
Review
作者: Sarac, Sinan B ; Schüssler-Lenz, Martina ; Müller-Berghaus, Jan
2020-07-01·Der Internist4区 · 医学
Tumorvakzinierung – therapeutische Vakzinierung gegen Krebs
4区 · 医学
Review
作者: Gouttefangeas, C ; Löffler, M W ; Walz, J S ; Haen, S P ; Rammensee, H-G ; Bokemeyer, C
2011-02-01·DMW - Deutsche Medizinische Wochenschrift4区 · 医学
Plasmide, Vektoren, Tumorvakzine - neue Impfkonzepte in der Diskussion
4区 · 医学
Article
作者: Bruhn, Claudia
100 项与 Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital) 相关的药物交易