(ELENTAL) - 在研适应症：营养紊乱_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ED-AC、L-イソロイシン/L-ロイシン/L-リシン塩酸塩/L-メチオニン/L-フェニルアラニン/L-トレオニン/L-トリプトファン/L-バリン/L-ヒスチジン塩酸塩水和物/L-アルギニン塩酸塩/L-アラニン/L-グルタミン/L-アスパラギン酸マグネシウム・カリウム/L-アスパラギン酸ナトリウム一水和物/グリシン/L-プロリン/L-チロシン/L-セリン/デキストリン/クエン酸ナトリウム水和物/塩化カリウム/グリセロリン酸カルシウム/グルコン酸第一鉄二水和物/硫酸亜鉛水和物/硫酸マンガン五水和物/硫酸銅/ヨウ化カリウム/チアミン塩化物塩酸塩/リボフラビンリン酸エステルナトリウム/ピリドキシン塩酸塩/シアノコバラミン/パントテン酸カルシウム/ニコチン酸アミド/葉酸/ビオチン/重酒石酸コリン/レチノール酢酸エステル/トコフェロール酢酸エステル/エルゴカルシフェロール/フィトナジオン/ダイズ油、L-异亮氨酸/L-亮氨酸/L-赖氨酸盐酸盐/L-甲硫氨酸/L-苯丙氨酸/L-苏氨酸/L-色氨酸/L-缬氨酸/L-组氨酸盐酸盐水合物/L-精氨酸盐酸盐/L-丙氨酸/L-谷氨酰胺/镁/L-天冬氨酸钾/L-天冬氨酸钠一水合物/甘氨酸/L-脯氨酸/L-酪氨酸/L-丝氨酸/糊精/柠檬酸钠水合物/氯化钾/甘油磷酸钙/葡萄糖酸亚铁二水合物/硫酸锌水合物/锰五水硫酸盐/硫酸铜/碘化钾/氯化硫胺盐酸盐/核黄素磷酸钠/盐酸吡哆醇/氰钴胺素/泛酸钙/烟酰胺/叶酸/生物素/酒石酸氢胆碱/视黄醇乙酸酯/生育酚乙酸酯/麦角钙化醇/苯甲萘醌/大豆油

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靶点-

作用机制-

治疗领域

内分泌与代谢疾病

在研适应症

营养紊乱

非在研适应症-

原研机构

EA Pharma Co., Ltd.

在研机构

EA Pharma Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1981-05-01),

营养紊乱

最高研发阶段(中国)-

特殊审评-

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关联

6

项与 ELENTAL 相关的临床试验

NCT02587611 / CompletedN/AIIT

Randomized Comparison of Elemental Liquid Diet and Standard Semi-solid Diet on Gastric Emptying in Healthy Subjects and Bedridden Gastrostomy-fed Patients

The purpose of this study is to compare the effect of either elemental liquid diet or standard semi-solid diet on gastric emptying in both healthy subjects and bedridden patients receiving gastrostomy feeding.

开始日期2015-11-01

申办/合作机构-

JPRN-UMIN000010370 / Completed临床2期IIT

Phase II study on reduction of mucous membrane inflammation by the nutritional supplement Elental in concurrent chemoradiotherapy for head and neck squamous cell carcinoma - Reduction of mucous membrane inflammation by Elental in concurrent chemoradiotherapy

开始日期2015-03-01

申办/合作机构-

JPRN-UMIN000009298 / Recruiting临床2期

Phase II study of elental for chemotherapy induced mucositis oral and nutritional disturbance - Phase II study of elental for chemotherapy induced mucositis oral and nutritional disturbance

开始日期2012-11-09

申办/合作机构-

100 项与 ELENTAL 相关的临床结果

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100 项与 ELENTAL 相关的转化医学

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100 项与 ELENTAL 相关的专利（医药）

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68

项与 ELENTAL 相关的文献（医药）

2023-12-15·Medicine

Positional dyspnea due to excessive dynamic airway collapse: A case report

Article

作者: Mao, Yanxiong ; Cui, Zhenghui ; Sun, Xiaoyan

Rationale:Excessive dynamic airway collapse (EDAC) is a form of dynamic central airway obstruction, with characteristic of excessive dynamic invagination of airway posterior wall membrane and structurally intact airway cartilage. We report a rare case of EDAC with a marked positional component.Patient concerns:A 73-year-old man was admitted to our hospital owing to dyspnea in right recumbent position (RRP). Also only in RRP, strong rhonchi was auscultated bilaterally through entire respiratory phase. He had gone through 3 episodes of resections on left lung due to hemoptysis caused by bronchiectasis, so he had only segment B1 + 2 and B3 left.Diagnoses:The spirometry results indicated that he had chronic obstructive pulmonary disease (COPD). The bronchoscopy revealed that in RRP, there was severe inward bulging of the posterior membrane of right main bronchus (RMB), which was worsened at expiratory phase. The EDAC of RMB was suspected, and was confirmed by an expiratory phase computed tomography (CT) in RRP. The EDAC was likely due to COPD, and the positional component was most likely to be caused by the removal of majority of his left lung.Interventions:Considering locality of EDAC and his overall stability, he was given a conservative approach. He was prescribed with budesonide/glycopyrrolate/formoterol for COPD and followed up.Outcomes:Two months later, the patient had relived dyspnea and weaker wheezing in RRP, and he had a good social and physical recovery.Lessons:Dyspnea may present as a diagnostic challenge, and it is rarely accompanied with a positional component. EDAC is an uncommon cause of dyspnea. This case illustrates the possible role of bronchoscopy and dynamic CT in dynamic evaluation of airway.

2023-10-01·Biomaterials Advances

Natural nanogels crosslinked with S-benzyl-L-cysteine exhibit potent antibacterial activity

Article

作者: Huang, Cheng-Rung ; Chen, Chang-Shi ; Chen, Yu-Fon ; Chung, Fang-Yu

Biofilm-forming bacteria E. coli and P. aeruginosa have both exhibited resistance against multiple antibiotics in clinical settings. To find a solution, researchers have turned to antibacterial structurally modified from natural materials that are harmless to the human body. Among these is DNA, a natural polymer composed of deoxyribose that when treated with HCl exposes its aldehyde groups and produces DNA-HCl. Here, we crosslinked these aldehyde groups with the primary amines in S-benzyl-L-cysteine (SBLC) using a Schiff reaction to obtain DNA-HCl-SBLC. We additionally treated alginate acid (AA) with EDAC, obtaining AA-EDAC, and substituting it with SBLC to produce AA-SBLC. We incorporated the above reactions with an emulsification process to produce nanogels (NGs) that were verified to be spherical and possessing benzene rings successfully grafted onto DNA-HCl and AA-EDAC. These natural NGs were proven to be negatively charged through zeta potential analysis and presented low cytotoxicity toward normal cells in cell organoid viability assays. These SBLC-modified polymers provided better inhibition of bacterial growth than those without modification. Moreover, after incubation with SBLC-modified NGs, bacteria expressed intracellular recA or pvdA in a dose-dependent manner, which was consistent with SEM data from damaged bacteria. Out of four tested NGs, DNA-HCl-SBLC NGs suppressed P. aeruginosa-induced sepsis most effectively and extended the lifespan of C. elegans. This study provides an alternative clinical solution to antibiotics-resistant biofilm strains.

2023-05-11·BMC complementary medicine and therapies

Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia.

Article

作者: Pieropan, Francesca ; Silva, Juliana Helena Castro E ; de Fátima Dias Costa, Maria ; Ribeiro, Paulo Roberto ; Salbego, Christianne Gazzana ; Longoni, Aline ; de Souza, Suzana Braga ; Costa, Silvia Lima ; Ferdandez, Luzimar Gonzaga ; Ferreira, Rafael Short ; Hoppe, Juliana Bender ; Rivera, Andrea Domenico ; Moreira, José Cláudio Fonseca ; Andrade, Gustavo Borges ; de Assis, Adriano Martimbianco ; de Almeida, Monique Marylin Alves ; Butt, Arthur Morgan ; de Lima Ferreira, Beatriz Correia ; da Silva, Victor Diogenes Amaral

Stroke is a leading cause of death and disability worldwide.A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate.In the brain, glutamate homeostasis is a primary function of astrocytes.Amburana cearensis has long been used in folk medicine and seed extract obtained with dichloromethane (EDAC) have previously been shown to exhibit cytoprotective activity in vitro.The aim of the present study was to analyze the activity of EDAC in hippocampal brain slices.We prepared a dichloromethane extract (EDAC) from A. cearensis seeds and characterized the chem. constituents by 1H and 13C-NMR.Hippocampal slices from P6-8 or P90 Wistar rats were used for cell viability assay or glutamate uptake test.Hippocampal slices from P10-12 transgenic mice SOX10-EGFP and GFAP-EGFP and immunofluorescence for GS, GLAST and GLT1 were used to study oligodendrocytes and astrocytes.Astrocytes play a critical role in glutamate homeostasis and we provide immunohistochem. evidence that in excitotoxicity EDAC increased expression of glutamate transporters and glutamine synthetase, which is essential for detoxifying glutamate.Next, we directly examined astrocytes using transgenic mice in which glial fibrillary acidic protein (GFAP) drives expression of enhanced green fluorescence protein (EGFP) and show that glutamate excitotoxicity caused a decrease in GFAP-EGFP and that EDAC protected against this loss.This was examined further in the oxygen-glucose deprivation (OGD) model of ischemia, where EDAC caused an increase in astrocytic process branching, resulting in an increase in GFAP-EGFP.Using SOX10-EGFP reporter mice, we show that the acute response of oligodendrocytes to OGD in hippocampal slices is a marked loss of their processes and EDAC protected oligodendrocytes against this damage.This study provides evidence that EDAC is cytoprotective against ischemia and glutamate excitotoxicity by modulating astrocyte responses and stimulating their glutamate homeostatic mechanisms.

100 项与 ELENTAL 相关的药物交易

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