盐酸奥布卡因/荧光素钠(Benoxinate Hydrochloride/Fluorescein Sodium) - 药物靶点：SCNA_在研适应症：麻醉，眼科外科手术_专利_临床

概要

基本信息

药物类型

小分子化药、荧光染料

别名

Altafluor benox

靶点

SCNA

作用方式

调节剂

作用机制

SCNA调节剂(钠通道α亚基家族调节剂)

治疗领域

其他疾病

在研适应症

麻醉眼科外科手术

非在研适应症-

原研机构

Altaire Pharmaceuticals, Inc.

在研机构

Altaire Pharmaceuticals, Inc.Bausch + Lomb Ireland Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (2017-12-14),

眼科外科手术

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C17H29ClN2O3

InChIKeyPRGUDWLMFLCODA-UHFFFAOYSA-N

CAS号5987-82-6

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关联

2

项与盐酸奥布卡因/荧光素钠相关的临床试验

NCT01959243

/ Completed临床3期

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% Used Four Times Daily in a Population of Pediatric, Adult, and Geriatric Subjects

To compare the safety and tolerability of brimonidine tartrate ophthalmic solution 0.025% versus its vehicle in a population of pediatric, adult, and geriatric participants. At least 51% of participants will be 40 years of age or older.

开始日期2014-02-22

申办/合作机构

Bausch & Lomb, Inc.

[+1]

NCT01959230

/ Completed临床3期

A Single-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% Used Four Times Daily in a Population of Adult and Geriatric Subjects With Ocular Redness

To compare the efficacy and safety of brimonidine tartrate ophthalmic solution 0.025% with its vehicle for the treatment of ocular redness in a population of adult and geriatric participants with ocular redness.

开始日期2013-11-07

申办/合作机构

Bausch & Lomb, Inc.

[+1]

100 项与盐酸奥布卡因/荧光素钠相关的临床结果

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100 项与盐酸奥布卡因/荧光素钠相关的转化医学

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100 项与盐酸奥布卡因/荧光素钠相关的专利（医药）

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1

项与盐酸奥布卡因/荧光素钠相关的文献（医药）

1994-05-01·American Journal of Ophthalmology2区 · 医学

Potential Bacterial Contamination of Eyedrops Used for Tonometry

2区 · 医学

Article

作者: Rebecca Palmberg ; Darlene Miller ; Douglas R. Anderson ; William J. Feuer ; Yanet Suarez Gutierrez

We compared the potential for bacterial contamination of a proparacaine hydrochloride solution preserved with benzalkonium chloride, which is used with fluorescein paper for tonometry, to that of a fluorescein-benoxinate hydrochloride combination solution preserved with chlorobutanol. We contaminated bottles of each solution with Pseudomonas aeruginosa or Staphylococcus aureus (10(7) organisms per milliliter of eyedrop solution). From the fluorescein-benoxinate hydrochloride solution, Staphylococcus organisms were cultured in declining numbers over time, with a half-life of nine seconds, and no Staphylococcus organisms were recovered after five minutes. Pseudomonas organisms disappeared from this solution within 15 seconds. Neither species was viable after 15 seconds in the proparacaine hydrochloride solution. Additionally, we cultured 12 bottles of fluorescein-benoxinate hydrochloride and 15 bottles of proparacaine hydrochloride that had been in use in the clinic for one month. No organisms were recovered from a drop dispensed from any bottle or from the tips, caps, rims, or solution from within any bottle, except that five colonies of Staphylococcus grew from the external rim of one bottle. We conclude that both solutions sterilize themselves rapidly and effectively. Either may be used safely for tonometry.

100 项与盐酸奥布卡因/荧光素钠相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	Bausch + Lomb Ireland Ltd.	2020-03-09
眼科外科手术	美国	Altaire Pharmaceuticals, Inc.	2017-12-14

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01959230 (CTgov)	临床3期	充血 \| 红斑	60	Brimonidine Tartrate+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate)	繭憲餘製鬱鹽築衊夢憲(醖觸鹹築鹽膚襯衊繭壓) = 糧網繭壓築糧鑰遞齋餘築顧積鹽鏇艱繭壓網簾 (蓋襯襯餘範壓觸構製製, 壓壓醖廠鹽網鹹獵鑰網 ~ 齋壓醖顧鹽網憲選選餘) 更多	-	2019-10-23
				Vehicle+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate Vehicle)	繭憲餘製鬱鹽築衊夢憲(醖觸鹹築鹽膚襯衊繭壓) = 鑰餘壓鑰憲顧糧鬱鏇壓築顧積鹽鏇艱繭壓網簾 (蓋襯襯餘範壓觸構製製, 淵範夢簾淵築鏇鏇構繭 ~ 簾顧蓋網簾選醖膚廠夢) 更多
NCT01959243 (CTgov)	临床3期	充血	507	Brimonidine Tartrate+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate)	鏇淵選顧積繭壓網憲構(艱蓋鏇構簾鹽壓糧鹽壓) = 鹽夢鹽願衊淵壓醖膚顧膚膚衊衊鏇醖鹹糧窪鬱 (鹹鬱願積遞艱廠鹽築顧, 網顧鏇鏇觸窪糧憲構襯 ~ 構膚衊網襯鬱製夢窪齋) 更多	-	2019-10-23
				Vehicle+Fluorescein Sodium+Sodium Fluorescein (Brimonidine Tartrate Vehicle)	鏇淵選顧積繭壓網憲構(艱蓋鏇構簾鹽壓糧鹽壓) = 繭積餘衊簾範選鹹齋築膚膚衊衊鏇醖鹹糧窪鬱 (鹹鬱願積遞艱廠鹽築顧, 壓網廠繭糧鑰鑰夢憲選 ~ 觸齋簾壓廠簾積簾製獵) 更多