Body Surface Potential Mapping during Atrial Depolarization in Rats with Post-Infarction Chronic Heart Failure against the Background of Fabomotizole Therapy

Article

作者: Ivonin, A G ; Kryzhanovskii, S A ; Tsorin, I B ; Roshchevskaya, I M ; Smirnova, S L ; Barchukov, V V

Cardiac remodeling in rats with post-infarction chronic heart failure caused by anterior transmural myocardial infarction leads to an atypical location of areas of positive and negative cardioelectric potentials on the body surface before the onset of the P_II-wave on the ECG in the limb leads, which is a sign of increased heterogeneity of atrial depolarization associated with the appearance of additional excitation focus in the left atrium. A course of therapy with fabomotizole leads to a decrease in the heterogeneity of atrial depolarization at the initial stages of the formation of the cardioelectric field of the atria on the body surface before the onset of the P_II-wave, thereby producing an antiarrhythmic effect.

2023-12-01·Bulletin of Experimental Biology and Medicine

The Effect of Original Russian Neurotropic Drugs on Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3

Article

作者: Konyakhin, E A ; Ganina, S O ; Yakusheva, E N ; Mylnikov, P Yu ; Abalenikhina, Yu V ; Shchulkin, A V ; Petrov, A V ; Erokhina, P D

In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3. It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3, fabomotizole did not affect the level of both transporters, and EMHPS (500 μM) increased the content of OATP1B1 compared to the control and did not affect the level of OATP1B3. The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease in the penetration of atorvastatin, a substrate of the transporters, into HepG2 cells in the presence of omberacetam (100-500 μM), fabomotizole (500 μM), and EMHPS (10-500 μM). Evaluation of clinical significance of the obtained results, according to the FDA approach based on the calculation of the C_max/IC₅₀ ratio, showed that the effect of the tested substances on OATP1B1/OATP1B3 is clinically insignificant.

2021-05-01·Bulletin of Experimental Biology and Medicine4区 · 医学

On the Mechanism of Cardioprotective Effect of Fabomotizole in Alcoholic Cardiomyopathy

4区 · 医学

Article

作者: Stolyaruk, V N ; Vititnova, M B ; Efimova, A O ; Kozhevnikova, L M ; Kryzhanovskii, S A ; Tsorin, I B

The molecular mechanisms underlying the cardioprotective effect of fabomotizole were studied using the translational rat model of alcoholic cardiomyopathy developed by us. It was shown that intraperitoneal administration of fabomotizole (15 mg/kg) for 28 days to animals with alcoholic cardiomyopathy contributes to normalization of the expression of mRNA of genes of regulatory proteins СаМ (p=0.00001), Ерас1 (p=0.021), and Ерас2 (p=0.018) and receptors RyR2 (p=0.0031) and IP3R2 (p=0.006) in the myocardium of the myocardium of the left ventricle that is enhanced in control animals (p<0.05). These changes were accompanied by echocardiographically documented decrease in the degree of left ventricle remodeling and improvement of its inotropic function.

100 项与 Fabomotizole 相关的药物交易

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