GYKI-17230(GYKI-17230) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Chinoin Zrt.

在研机构-

非在研机构

Chinoin Zrt.

权益机构-

最高研发阶段终止临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C10H22O10S2

InChIKeyLJBKHHZPVCABCX-ZYUZMQFOSA-N

CAS号71240-74-9

关联

100 项与 GYKI-17230 相关的临床结果

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100 项与 GYKI-17230 相关的转化医学

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100 项与 GYKI-17230 相关的专利（医药）

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3

项与 GYKI-17230 相关的文献（医药）

1979-06-01·Carbohydrate Research

3,4-di-O-alkylhexitol derivatives containing biological alkylating groups at C-1 and C-6

作者: János Kuszmann

For studying the structure-activity relationship of cytostatically active hexitol derivatives, 1,2:5,6-dianhydro-3,4-di-O-methyl- (I), -ethyl-, -allyl-, and -pentyl-D-mannitol, as well as 1,2:5,6-dianhydro-3,4-di-O-methyl-L-iditol, -galactitol, and -D-glucitol were prepared; in the preparation of I, 2,5-di- O acetyl-1,6-di-O-mesyl-3,4-di-O-methyl-D-mannitol was used as an intermediate that could be deacetylated to give 1,6-di-O-mesyl-3,4-di-O-methyl-D-mannitol, a compound that proved to be about 10 times as active as 1,6-di-O-mesyl-D-mannitol (Mannitol-Myleran), a known cytostatic compound

Acta Chimica Hungarica

Synthesis of "double-headed" bis-homonucleoside analogs

作者: Kuszmann, J. ; Pelczer, I.

The title nucleoside analogs containing an oxolane ring with D-arabino and L-lyxo configuration were prepared via 1,3-dipolar cycloaddition reactions of 1,6-diazido-1,6-dideoxy-2,5-anhydro-D-glucitol and -L-iditol derivatives with di-Me acetylenedicarboxylate (I) or cyanoacetamide.Thus, glucitol II was treated with I in Me₂CO to give 68.4% nucleoside analog III.The oxirane ring of IV was split on acetylation with Ac₂O in pyridine to give monoacetate V.A mechanism for this unusual reaction is proposed.Some bis-homo-C-nucleoside analogs were also prepared containing an oxolane ring with D-arabino configuration and differently substituted 1,2,4-triazole rings as heterocyclic bases.

Development of 1,6-di-O-methylsulfonyl-3,4-di-O-methyl-D-mannitol (GYKI-17 230), a new cytostatic agent

作者: Tory, K. ; Kiraly, E. ; Kuszmann, J. ; Vamos, S. ; Csanyi, E.

GYKI 17230 (I) [71240-74-9], a new alkylating agent, is active against a broad range of exptl. tumors including transplantable leukemia, solid tumors intracerebral tumors. metastasis models, and xenotransplanted human tumors.I is water-soluble and active both orally and parenterally.I is as active as cyclophosphamide, but without its immunosuppressive activity.

100 项与 GYKI-17230 相关的药物交易

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