RE-02(RE-02) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Reconnect Labs

在研机构

Reconnect Labs

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

1

项与 RE-02 相关的临床试验

NCT05979727 / Recruiting临床1期

Double-blind, Randomized, Dose-response Study of RE02 in Healthy Subjects

The goal of this clinical trial is to compare corresponding inter- and intraindividual pharmacokinetic and pharmacodynamic profiles including assessments of safety & tolerability of three different doses against a placebo control.

开始日期2023-11-20

申办/合作机构

Reconnect Labs

100 项与 RE-02 相关的临床结果

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100 项与 RE-02 相关的转化医学

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100 项与 RE-02 相关的专利（医药）

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1

项与 RE-02 相关的文献（医药）

2021-02-01·New Phytologist1区 · 生物学

A receptor‐like protein from Nicotiana benthamiana mediates VmE02 PAMP‐triggered immunity

1区 · 生物学

Article

作者: Zhou, Wenjing ; Liu, Jianying ; Nie, Jiajun ; Huang, Lili ; Zhou, Jian‐Min ; Tan, Ni

Summary

Plants use their innate immune system to defend against phytopathogens. As a part of this, pattern triggered‐immunity is activated via pattern recognition receptor (PRR) detection of pathogen‐associated molecular patterns (PAMPs). Although an increasing number of PAMPs have been identified, the PRRs for their recognition remain largely unknown.

In the present study, we report a receptor‐like protein RE02 (Response to VmE02) in Nicotiana benthamiana, which mediates the perception of VmE02, a PAMP previously identified from the phytopathogenic fungus Valsa mali, using virus‐induced gene silencing (VIGS), co‐immunoprecipitation, pull‐down and microscale thermophoresis assays.

We show that silencing of RE02 markedly attenuated VmE02‐triggred cell death and immune responses. RE02 specifically interacted with VmE02 in vivo and in vitro, and it displayed a high affinity for VmE02. Formation of a complex with the receptor‐like kinases SOBIR1 and BAK1 was essential for RE02 to perceive VmE02. Moreover, RE02‐silenced plants exhibited enhanced susceptibility to both the oomycete Phytophthora capsici and the fungus Sclerotinia sclerotiorum, while overexpression of RE02 increased plant resistance to these pathogens.

Together, our results indicate that the PAMP VmE02 and the receptor‐like protein RE02 represent a new ligand–receptor pair in plant immunity, and that RE02 represents a promising target for engineering disease resistance.

100 项与 RE-02 相关的药物交易

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